Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.

CONCLUSIONS: Our findings establish PS as an important in vivo inhibitor of FIXa. Disruption of the interaction between PS and FIXa causes an increased rate of thrombus formation in mice. This newly discovered function of PS implies an unexploited target for antithrombotic therapeutics. PMID: 29419409 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29419409?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2018 Category: Cardiology Authors: Plautz WE, Sekhar Pilli VS, Cooley BC, Chattopadhyay R, Westmark PR, Getz T, Paul D, Bergmeier W, Sheehan JP, Majumder R Tags: Arterioscler Thromb Vasc Biol Source Type: research