Systematic review of hormone replacement therapy in the infertile man

Conclusions Exogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research

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AbstractPurpose of ReviewTo discuss the physiologic and pathologic effects of iron on men ’s reproductive health.Recent FindingsIron overload diseases are associated with hypogonadotropic hypogonadism, infertility, and sexual dysfunction in men. Recent findings have elucidated the roles by which iron may affect the male reproductive axis.SummaryIron is requisite for life. Iron can also catalyze the production of reactive oxygen species. To maintain balance, the human body tightly regulates dietary iron absorption. Severe iron overload disorders —e.g., hereditary hemochromatosis and β-thalassemia—occu...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
AbstractPurpose of ReviewNon-standard shift work schedules negatively impact the overall health of shift workers, and several studies have shown that shift work, specifically, is detrimental to urogenital health. The aims of this study are to systematically review the literature and determine the effect of shift work on the outcomes of hypogonadism, male infertility, lower urinary tract symptoms, and urogenital cancers.Recent FindingsRecent evidence supports associations between non-standard shift work and an increase in the frequency of prostate cancer and the severity of erectile dysfunction, lower urinary tract symptoms...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
Abstract Prolactin-secreting adenomas, or prolactinomas, cause hypogonadism, osteoporosis, and infertility. Although dopamine agonists (DAs) are used clinically to treat prolactinoma, and reduce prolactin secretion via cAMP inhibition, the precise mechanism by which DAs inhibit lactotrope proliferation has not been defined. Here we report the novel finding that PI3K signals through AKT and mTOR to drive proliferation of pituitary somatolactotrope GH4T2 cells. We demonstrate that the DA cabergoline reduces activity of the mTOR effector s6K, and diminishes GH4T2 cell proliferation primarily via activation of the lon...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
Authors: Fung C, Dinh P, Ardeshir-Rouhani-Fard S, Schaffer K, Fossa SD, Travis LB Abstract Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
Abstract Recent evidences suggest that hypogonadism is an important risk factor for lower urinary tract symptoms and benign prostatic hyperplasia. Several papers have discussed the role of chronic inflammation in the development of BPH, which may be modulated by the hypogonadal state. Soluble urokinase-type plasminogen activator receptor (suPAR), known protein marker of systemic inflammation, can be assayed in the seminal plasma and represents a reliable and sensitive marker of inflammation for the male accessory gland inflammation (MAGI). The aim of this study has been to investigate if seminal suPAR is elevated ...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
Testosterone deficiency has been linked to several adverse health outcomes - including cardiovascular disease, erectile dysfunction, and metabolic syndrome. Recent data has suggested that abnormal sleep quality may result in lower testosterone levels. Using the 2011- 2012 National Health and Nutrition Surveys (NHANES) we assessed the effect of self-reported sleep patterns on serum testosterone while controlling for physical activity levels, co-morbidities, and baseline demographics.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Epidemiology & Evaluation I Source Type: research
Excess nitrosative stress can lead to erectile dysfunction and infertility. We tested the hypothesis that nitrosative stress affects the hypothalamus-pituitary-gonadal axis leading to secondary hypogonadism.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Sexual Function/Dysfunction: Basic Research & Pathophysiology I Source Type: research
Sertoli cells thrive in an environment of high testosterone concentrations. Therefore, when subjected to low levels of testosterone, from any cause, abnormal spermatogenesis may occur. We performed a secondary analysis of a large, prospective clinical trial of couples with unexplained infertility to analyze whether sperm quality and pregnancy/live birth (LB) rates were associated with low total testosterone (TT).
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Basic Research & Pathophysiology Source Type: research
The primary goal in treatment of idiopathic hypogonadotropic hypogonadism (IHH) is to induce masculinization and spermatogenesis. Exogeneous testosterone (T) can induce masculinization but not spermatogenesis and rather may be associated with impaired spermatogenesis. This retrospective study aims to determine whether concomitant T based on HCG treatment show significantly harmful impacts on spermatogenesis in IHH patients compared HCG alone.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Therapy II Source Type: research
Follicle-stimulating hormone (FSH) is a gonadotropin produced by the anterior pituitary gland and is trophic to the sertoli cells to maintain spermatogenesis. FSH is prescribed to men with hypogonadotropic hypogonadism (congenital or acquired) seeking fertility. Commercially available FSH, branded Gonal-F (B-FSH), is often cost prohibitive for patients, leading to the recent development of compounded alternatives. Here we compare the clinical and cost-effectiveness of B-FSH with compounded FSH (C-FSH).
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Therapy II Source Type: research
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