Terpenoids from Vitex trifolia and their anti-inflammatory activities

AbstractA new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-β-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6β-dihydroxy iridoid 1-O-β-D-glucopyranoside (2), along with six known compounds (3-8) were isolated fromVitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds2,4,5, and7 showed moderate inhibitory activities with IC50 values of 90.05, 88.51, 87.26, and 76.06  μM, respectively.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research