Pharmacogenomics signature: A novel strategy on the individual differences in drug response

Patients exhibit a wide heterogeneity in their responses to a drug treatment due to variations in the molecular determinants underlying this heterogeneity. Pharmacogenomics approaches can be used to integrate information on drug responsiveness with alterations in molecular entities, often on a genome-wide scale. However, most of the studies involving pharmacogenomics of specific therapeutics are in their early stages and thus are not ready for clinical utilization. Genotyping studies tackle around a candidate gene approach using genes known to be important in the pharmacokinetics and pharmacodynamics of the administered drugs.

Source: Cancer Letters - February 9, 2018 Category: Cancer & Oncology Authors: Chengxian Guo, Xinjian Lin, Jiye Yin, Xiaoxue Xie, Jingao Li, Xiangguang Meng, Jichu Wu, Lihua Huang, Zhijun Huang, Guoping Yang, Honghao Zhou, Xiang Chen Tags: Mini-review Source Type: research