Contributions of micro- and macrovascular disease to reduced substantia innominata volume and cognitive deficits in Alzheimer ’s disease

The relationships between cholinergic system damage and cerebrovascular disease are not entirely understood. Here we investigate associations between atrophy of the substantia innominata (SI; the origin of cortical cholinergic projections) and measures of large and small vessel disease; specifically, elongation of the juxtaposed internal carotid artery termination and Cholinergic Pathways Hyperintensity scores (CHIPS). The study consisted of 105 patients with Alzheimer ’s disease (AD), subcortical ischemic vasculopathy (SIV), and elderly controls.

Source: Neurobiology of Aging - February 9, 2018 Category: Neuroscience Authors: Gurpreet Jaswal, Walter Swardfager, Fu-qiang Gao, Sean Nestor, Anoop Ganda, Hugo Cogo-Moreira, Demetrios Sahlas, Donald T. Stuss, Alan Moody, Sandra E. Black Source Type: research