Neuroprotective Effects of Phenolic and Carboxylic Acids on Oxidative Stress-Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells.

Neuroprotective Effects of Phenolic and Carboxylic Acids on Oxidative Stress-Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells. Neurochem Res. 2018 Feb 07;: Authors: Gay NH, Phopin K, Suwanjang W, Songtawee N, Ruankham W, Wongchitrat P, Prachayasittikul S, Prachayasittikul V Abstract An increase in oxidative stress is a key factor responsible for neurotoxicity induction and cell death leading to neurodegenerative diseases including Parkinson's and Alzheimer's diseases. Plant phenolics exert diverse bioactivities i.e., antioxidant, anti-inflammatory, and neuroprotective effects. Herein, phenolic compounds, namely protocatechuic aldehyde (PCA) constituents of Hydnophytum formicarum Jack. including vanillic acid (VA) and trans-ferulic acid (FA) found in Spilanthes acmella Murr., were explored for anti-neurodegenerative properties using an in vitro model of oxidative stress-induced neuroblastoma SH-SY5Y cells. Exposure of the neuronal cells with H2O2 resulted in the decrease of cell viability, but increasing in the level of reactive oxygen species (ROS) together with morphological changes and inducing cellular apoptosis. SH-SY5Y cells pretreated with 5 µM of PCA, VA, and FA were able to attenuate cell death caused by H2O2-induced toxicity, as well as decreased ROS level and apoptotic cells after 24 h of treatment. Pretreated SH-SY5Y cells with phenolic compounds also helped to upregulate H2O2-induced depletion of the expressions of sirtui...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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Publication date: Available online 17 February 2020Source: Materials Today: ProceedingsAuthor(s): Michelina Catauro, Federico Barrino, Ignazio Blanco, Giovanni Dal Poggetto, Simona Piccolella, Giuseppina Crescente, Severina PacificoAbstractSol-gel chemistry is an attractive approach in the design of new antioxidant biomaterials. Its versatility was exploited to obtain organic-inorganic hybrid materials in which a natural antioxidant compound, namely chlorogenic acid (CGA), was entrapped, in different percentage, in matrices variously constituted in silica and PEG400.The synthetized hybrids were chemically characterized by ...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
ConclusionIn our study, both CR and PE prevented age-related changes in the corpus cavernosum of rats. Reducing nitrosative damage in the neurovascular structure was the main mechanism. CR and exercise restored the endothelial and smooth muscle cells in corpus cavernosum by decreasing apoptosis. The mechanism of enhancing functional response in corpus cavernosum with CR was the improvement of endothelial function via eNOS activation however it involves increases in the NO-cGMP signaling pathway by an endothelium-independent mechanism with PE. This might be a direct stimulation of smooth muscle cells by NO, which released f...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 17 February 2020Source: LWTAuthor(s): Jennifer V. Félix-Medina, Julio Montes-Ávila, Cuauhtémoc Reyes-Moreno, J. Xiomara K. Perales-Sánchez, Mario A. Gómez-Favela, Ernesto Aguilar-Palazuelos, Roberto Gutiérrez-DoradoAbstractSnacks directly expanded (second-generation) are trendy in the market, but considered products of poor nutritional due to usually made with corn starch. In this research, optimization of the extrusion process variables and the bean flour inclusion level was carried out to develop optimized expanded snacks (OES) with high nutriti...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 17 February 2020Source: LWTAuthor(s): Josiana M. Mar, Laiane S. Silva, Maxwaldo da S. Rabelo, Magno P. Muniz, Sergio M. Nunomura, Renilto F. Correa, Valdely Ferreira Kinupp, Pedro H. Campelo, Jaqueline de A. Bezerra, Edgar A. SanchesAbstractBioactive compounds of Clidemia japurensis and Clidemia hirta juices were encapsulated in maltodextrin (MD) of different dextrose equivalents (DE – MD10, MD20 AND MD30). Microparticles containing the encapsulated juices were obtained by freeze-drying process. The stability of the encapsulated bioactive compounds was evaluated under different rela...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 17 February 2020Source: Food Research InternationalAuthor(s): Francielli P.R. de Morais, Tássia B. Pessato, Eliseu Rodrigues, Luana Peixoto Mallmann, Lilian R.B. Mariutti, Flavia M. NettoAbstractWhey protein isolate (WPI) interactions with (-)-epigallocatechin gallate (EGCG) and caffeic acid (CA) at pH 3.5 and 7.0 were investigated concerning complex formation and antioxidant capacity, before and after simulated digestion. Complex formation was evidenced by protein structural changes when WPI was associated with CA or EGCG. Reducing capacity and FRAP values increased as the phenoli...
Source: Food Research International - Category: Food Science Source Type: research
Conditions:   Leukemia;   Lymphoma;   Leukemia, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Lymphoma, Large B-Cell, Diffuse;   Leukemia, B-cell;   Lymphoma, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Lymphoma;   Leukemia, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Leukemia;   Lymphoma, Large B-Cell, Diffuse;   Leukemia, B-cell;   Lymphoma, B-Cell;   Leukemia, Lymphocytic, Chronic, B-Cell Intervention:   Biological: CD19 CAR-T cells Sponsor:   Chongqing Precision Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
MONDAY, Feb. 17, 2020 (American Heart Association News) -- Bleeding strokes are the deadliest type of stroke and the hardest to treat. What might make matters worse is having both diabetes and Alzheimer's disease versus either condition alone, new...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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