Runx2 overexpression compromises bone quality in acromegalic patients

In conclusion, this study demonstrates the key role of RUNX2 gene overexpression in causing bone impairment in acromegalic patients. It also suggests a therapeutic approach for the improvement of bone quality, focused on the osteoblastic lineage rather than the inhibition of osteoclastic activity.

Source: Endocrine-Related Cancer - February 5, 2018 Category: Endocrinology Authors: Valenti, M. T., Mottes, M., Cheri, S., Deiana, M., Micheletti, V., Cosaro, E., Davi, M. V., Francia, G., Dalle Carbonare, L. Tags: Research Source Type: research