When Is'Normal' Not OK?
(MedPage Today) -- Study links lab values within normal range to infertility
Publication date: Available online 18 July 2018Source: PeptidesAuthor(s): Sevil Arabaci Tamer, Alper Yildirim, M. Kutay köroğlu, Özge Çevik, Feriha Ercan, Berrak Ç. YeğenAbstractTesticular torsion causes ischemia-reperfusion injury and an increased risk of infertility. Nesfatin-1 is a novel peptide with antioxidant, anti-inflammatory and anti-apoptotic properties. In the present study, we aimed to investigate the putative beneficial effects of nesfatin-1 on oxidative injury and impaired testicular function induced by testis torsion. Under anesthesia, male Sprague-Dawley rats (180-230 g; n = ...
Conditions: Infertility, Female; Endometrium Intervention: Procedure: UC-MSCs therapy Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Acephalic spermatozoa syndrome is a severe teratozoospermia that leads to male infertility. Our previous work showed that biallelic SUN5 mutations are responsible for acephalic spermatozoa syndrome in about half of affected individuals, while pathogenic mechanisms in the other individuals remain to be elucidated. Here, we identified a homozygous nonsense mutation in the testis-specific gene PMFBP1 using whole-exome sequencing in a consanguineous family with two infertile brothers with acephalic spermatozoa syndrome.
Authors: Zarandi NP, Galdon G, Kogan S, Atala A, Sadri-Ardekani H Abstract While the survival rate of children with cancer is increasing, preserving fertility for prepubertal boys is still a challenge. Although intracytoplasmic sperm injection (ICSI) using frozen sperms has revolutionized infertility treatment, it is not applicable for the patients who undergo chemotherapy before puberty since spermatogenesis has not begun. Therefore, preserving spermatogonial stem cells (SSCs) as an experimental option can be provided to prepubertal patients at a risk of damage or loss of their SSCs due to cancer treatments and de...
Conditions: Mrk Anomaly; Infertility, Female Intervention: Procedure: uterus transplantation surgery and IVF Sponsors: Sahlgrenska University Hospital, Sweden; Saint Joseph University, at Bellevue Medical Centre Recruiting
Condition: Infertility, Male Interventions: Dietary Supplement: Dietary Supplement with L-carnitine (FertilHom); Dietary Supplement: Control Dietary Supplement Sponsor: NATURAmedicatrix Sàrl Not yet recruiting
CONCLUSION: Despite a more frequent presentation with advanced disease, colorectal cancer has a similar prognosis in pregnancy when compared with the general population. Diagnostic interventions and treatment should not be delayed due to the pregnancy but a balance between maternal and foetal wellbeing must always be kept in mind. PMID: 30010511 [PubMed - as supplied by publisher]
[Nairobi News] Two in every 10 couples suffer from infertility, data has shown.
Conclusions: We found no associations of bisphenols and phthalates with fecundability. Preconception folic acid supplementation seems to modify effects of bisphenols and phthalates on fecundability. Folic acid supplements may protect against reduced fecundability among women exposed to these chemicals. Further studies are needed to replicate these findings and investigate potential mechanisms. PMID: 30016447 [PubMed - as supplied by publisher]
CONCLUSION: Trends favoring twice daily dosing are encouraging findings and require further investigation. PMID: 29999292 [PubMed - in process]