Cancers, Vol. 10, Pages 46: Liver Transplantation for Alcoholic Liver Disease and Hepatocellular Carcinoma

Cancers, Vol. 10, Pages 46: Liver Transplantation for Alcoholic Liver Disease and Hepatocellular Carcinoma Cancers doi: 10.3390/cancers10020046 Authors: Patrizia Burra Alberto Zanetto Giacomo Germani Hepatocellular carcinoma is one of the main important causes of cancer-related death and its mortality is increasingly worldwide. In Europe, alcohol abuse accounts for approximately half of all liver cancer cases and it will become the leading cause of hepatocellular carcinoma in the next future with the sharp decline of chronic viral hepatitis. The pathophysiology of alcohol-induced carcinogenesis involves acetaldehyde catabolism, oxidative stress and chronic liver inflammation. Genetic background plays also a significant role and specific patterns of gene mutations in alcohol-related hepatocellular carcinoma have been characterized. Survival is higher in patients who undergo specific surveillance programmes than in patients who do not. However, patients with alcohol cirrhosis present a significantly greater risk of liver decompensation than those with cirrhosis due to other aetiologies. Furthermore, the adherence to screening program can be suboptimal. Liver transplant for patients with Milan-in hepatocellular carcinoma represents the best possible treatment in case of tumour recurrence/progression despite loco-regional or surgical treatments. Long-term result after liver transplantation for alcohol related liver disease is good. However, cardiovascular disease and ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research