Maryland Sues Insys to Enforce Subpoena in Opioid Probe Maryland Sues Insys to Enforce Subpoena in Opioid Probe

Maryland's attorney general has filed a lawsuit seeking to enforce a subpoena the state sent Insys Therapeutics Inc as part of a probe into allegations the drugmaker deceptively marketed a fentanyl-based cancer pain medicine.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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ConclusionsCancer survivors in rural China have deteriorated HRQoL, and a substantial number of survivors have pain/discomfort problems. Our study provides detailed data on HRQoL of rural cancer survivors for future supportive and survivorship care in China.
Source: Quality of Life Research - Category: Health Management Source Type: research
Younger women are having more heart attacks, and accounted for nearly a third of all female heart attack patients in recent years, according to a recent study. The news compounds a string of recent findings that have pointed to poorer overall health for young American women. “Women now, compared to younger women generations before them, are less healthy,” says study co-author Melissa Caughey, a cardiovascular epidemiologist and instructor at the University of North Carolina Chapel Hill School of Medicine. “It’s probably reflective of poorer health in general.” The study, which appeared in a sp...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Research Source Type: news
LUNG cancer symptoms include a cough the won ’t go away, unexplained weight loss and severe chest pain. But you could also be at risk of deadly lung tumour signs if your eyes are a distinctive colour.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Marilyn Steele's roller-coaster ride of pain and panic began in December when she was diagnosed with a fast-moving cancer. After undergoing surgery days later in Florida, her family says she's at risk of losing her home to cover tens of thousands of dollars in surgery bills because New Brunswick won't pay them.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/New Brunswick Source Type: news
Marilyn Steele's roller-coaster ride of pain and panic began in December when she was diagnosed with a fast-moving cancer. After undergoing surgery days later in Florida, her family says she's at risk of losing her home to cover tens of thousands of dollars in surgery bills because New Brunswick won't pay them.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/New Brunswick Source Type: news
A repurposed cancer drug appears to reduce the severity of lesions and pain experienced by people with Proteus syndrome, a rare genomic disease. Some researchers believe that Joseph Merrick, known as the Elephant Man, may have suffered from Proteus syndrome.
Source: NHGRI Homepage Highlights - Category: Genetics & Stem Cells Source Type: news
In this study, we revisited this claim by independently evaluating the proposed marker haplotype using 2 different patient cohorts recruited in different research settings. Meta-analysis of these new postmastectomy cohorts and the original cohort confirmed significant association of the CACNG2 haplotype with PMP. In addition, we tested whether the same markers would predict chronic postsurgical pain in men who underwent surgery for inguinal hernia repair, and whether there is significant genetic association with cutaneous thermal sensitivity in postmastectomy and postherniotomy patients. We found that the biomarker is sele...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
In this study, we report that daily treatment with decitabine (2 µg/g, intraperitoneally) attenuated nociceptive behavior in the 4T1-luc2 mouse model of bone cancer pain. We hypothesized that the analgesic mechanism of decitabine involved activation of the endogenous opioid system through demethylation and reexpression of the transcriptionally silenced endothelin B receptor gene, Ednrb. Indeed, Ednrb was hypermethylated and transcriptionally silenced in the mouse model of bone cancer pain. We demonstrated that expression of Ednrb in the cancer cells lead to release of β-endorphin in the cell supernatant, which r...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Our recent work has shown that the early-life administration of vincristine (VNC), commonly used to treat pediatric cancers, evokes mechanical pain hypersensitivity in rats that emerges during adolescence and persists into adulthood. However, the underlying mechanisms remain unclear, as nothing is known about how neonatal VNC treatment influences peripheral and central nociceptive processing at the cellular level. Here, we used in vitro intracellular microelectrode and whole-cell patch-clamp recordings to evaluate the consequences of early-life VNC administration on the intrinsic membrane properties of adolescent dorsal ro...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Conditions:   Organic, Including Symptomatic, Mental Disorders;   Substance Use;   Schizophrenia;   Mood [Affective] Disorders;   Neurotic, Stress-related and Somatoform Disorders;   Eating Disorder;   Disorders of Adult Personality and Behavior;   Mental Retardation;   Disorder of  Psychological Development;   Behavioural Disorder;   Hypertension;   Dyslipidemias;   Ischemic Heart Disease;   Atrial Fibrillation;   Heart ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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