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Maryland Sues Insys to Enforce Subpoena in Opioid Probe Maryland Sues Insys to Enforce Subpoena in Opioid Probe

Maryland's attorney general has filed a lawsuit seeking to enforce a subpoena the state sent Insys Therapeutics Inc as part of a probe into allegations the drugmaker deceptively marketed a fentanyl-based cancer pain medicine.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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BOWEL cancer symptoms include stomach pain, a change in bowel habits, and finding blood in your stool. You could reveal your risk of the cancer by checking your poo after using the toilet. Should a healthy poo sink or float?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We present a case of bladder cancer manifesting with insidious foot pain, caused by multiple lytic lesions located solely at the left foot. It was suspected after whole-body CT and later confirmed by biopsy result. We enumerate the differential diagnosis of distal extremity lytic lesions for educational purposes and review the literature listing similar published cases.
Source: Skeletal Radiology - Category: Radiology Source Type: research
Authors: Ida T, Goto T, Motoi T, Nagai I, Matsubara S, Fujiwara H, Kohyama A Abstract A bone metastasis from uterine cervical cancer normally indicates short life expectancy. Resection of the lesion is therefore palliative. The authors consider herein whether surgical resection can promote disease control while improving quality of life. A 33-year-old woman -presenting FIGO Stage IB 1 uterine cervical squamous cell carcinoma underwent a radical hysterectomy and pelvic irradiation. Twenty-two-months later, a solitary femoral metastasis was detected. Given the pain, imminent bone fracture, the patient's relative yout...
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
Conditions:   Bone Pain;   Breast Carcinoma Metastatic in the Bone Interventions:   Procedure: Biospecimen Collection;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CERVICAL cancer symptoms include unusual bleeding, back pain, and passing more stools than usual. But, you should never ignore constipation pain, as it could be a sign of a tumour.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: 1 July 2018 Source:Life Sciences, Volume 204 Author(s): Marek Toczek, Barbara Malinowska The endocannabinoid system is up-regulated in numerous pathophysiological states such as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular diseases, pain, and cancer. It has been suggested that this phenomenon primarily serves an autoprotective role in inhibiting disease progression and/or diminishing signs and symptoms. Accordingly, enhancement of endogenous endocannabinoid tone by inhibition of endocannabinoid degradation represents a promising therapeutic approach for the treatment of...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Nguyen BC, Kim SA, Won SM, Park SK, Uto Y, Maruta H Abstract PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16 gene. 15K is a highly cell-permeable 1,2,3-triazolyl ester of ketorolac that down-regulates both PAK1 and its down-stream COX-2 in R- and S-forms, respectively. 15K is 500-5,000 times more potent than ketorolac, an old pain-killer, inhibiting the growth of cancer cell lines with IC50 ranging 5-24 nM. Scores of natural and synthetic PAK1-blockers have been shown to extend the lifespan of small...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
BOWEL cancer symptoms can include stomach pain, a change in bowel habits, and finding blood in your stool. But, blood in your poo could also be a sign of haemorrhoids - this is how to tell the difference.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
People may feel aches or pains in their bones for a variety of reasons. Many people worry when they experience bone pain because it can be a sign of bone cancer. For this reason, prompt diagnosis is essential. Learn more about bone pain symptoms, the signs of cancer, and when to see a doctor.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news
Conclusions Approximately two-thirds of patients who undergo treatment with radium-223 will experience an improvement in pain and, if it occurs, it will most likely occur within the first two cycles. Patients should be counseled about this timeline and, if pain improvement isn't achieved, palliative radiation and oral analgesic readjustment should be considered. Pain response is not associated with survival and should not be used to evaluate the effectiveness of treatment.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
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