Scientists Create First Lab-Grown Human Eggs

U.K. researchers who created the first laboratory-grown human eggs say their achievement could lead to news ways to preserve the fertility of girls undergoing radiation or chemotherapy for cancer.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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A novel strategy of EGFR‑TKI combined chemotherapy in the treatment of human lung cancer with EGFR‑sensitive mutation. Oncol Rep. 2018 Jun 18;: Authors: Zhang L, Qi Y, Xing K, Qian S, Zhang P, Wu X Abstract The discovery of epidermal growth factor receptor (EGFR)‑sensitive mutations in non‑small cell lung cancer (NSCLC) and the successful clinical application of EGFR tyrosine kinase inhibitors (TKIs) have changed the regimen of lung cancer therapy from traditional cytotoxic chemotherapy to molecular‑targeted cancer therapy. However, the main limitation of EGFR‑TKI therapy is the hetero...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, Morisawa G, Yanagisawa Y, Ito E, Imai JI, Dobashi Y, Katahira K, Soeda S, Watanabe T, Fujimori K, Watanabe S, Takagi M Abstract Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived tumor organoids (PDOs) were established from human lung, ovarian and uterine tumor tissues, among others, to accurately and efficiently recapitulate the tissue architecture...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8NJ01790E, PaperMahdi Rahimi, ramin karimian, Elmira Mostafidi, Ehsan Bahojb Noruzi, Sepehr Taghizadeh, Behrooz Shokouhi, Hossein Samadi Samadi Kafil Nanotechnology has recently emerged as a promising field in biomedical applications especially in the targeted delivery of drugs to tumors. Besides, combination chemotherapy is common in cancer treatment and rapidly... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Scientists at San Antonio ’s Texas Biomedical Research Institute are studying the effectiveness of promising experimental cancer chemotherapy drugs in defeating another life-threatening disease — tuberculosis, or TB.  That exploration could help beat back an illness that has surpassed AIDS as the world’s single most lethal infectious disease. A scientific team led by Texas Biomed’s Eusondia Arnett have pinpointed a mechanism in regulating cell death called apoptosis that is a potential…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
Mutations or other alterations in theRET gene have been implicated in a variety of malignancies – most commonly thyroid, but also chronic myelomonocytic leukemia, acute myeloid leukemia, and lung, breast, pancreatic, and colon cancers. Here we present a case of a gentlemen initially diagnosed with and treated for non-small cell lung adenocarcinoma. Genomic profiling of his tumor specimen rev ealed aRET point mutation with a known association with medullary thyroid cancer (MTC). Further pathological and molecular diagnostic evaluation confirmed a diagnosis of MTC, leading to a change in treatment from standard chemoth...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Scientists have discovered a new way in which bacteria residing in the human gut may be able to contribute to chemotherapy resistance.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Are oncologists recommending less chemotherapy for early breast cancer?Journal of the National Cancer Institute
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
(Texas Biomedical Research Institute) Promising experimental cancer chemotherapy drugs may help knock out another life-threatening disease: tuberculosis (TB). A new study published by scientists at Texas Biomedical Research Institute in San Antonio pinpoints a mechanism in regulating cell death called apoptosis that is a potential new target for helping to control the bacterial infection (Mycobacterium tuberculosis or M.tb) that causes the lung disease TB.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
In conclusion, euphol exerted in vitro and i n vivo cytotoxicity against glioma cells, through several cancer pathways, including the activation of autophagy-associated cell death. These findings provide experimental support for further development of euphol as a novel therapeutic agent for GBM, either alone or in combination chemotherapy.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Publication date: 1 October 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 170 Author(s): Yanhua Liu, Chengming Zhou, Shijie Wei, Tong Yang, Yang Lan, Aichen Cao, Jianhong Yang, Yanhui Hou The drug efflux mediated by P-glycoprotein (P-gp) transporter is a major factor responsible for multidrug resistance (MDR) of paclitaxel (PTX). The efficient intracellular PTX delivery is a promising strategy for overcoming the MDR of tumor cells. A CD44 receptor targeting and endosome-pH sensitive dual functionalized hyaluronic acid-deoxycholic acid-histidine (HA-DOCA-His) micellar formulation was developed to overcome MDR,...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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