Historic flu is now worst in decades:10 more children dead

Acting CDC director Dr Anne Schuchat said on Friday that this season is as bad as the 2009 swine flu pandemic that killed 200,000 people and we may not have reached the peak yet.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Condition:   Influenza, Avian Interventions:   Biological: GHB04L1;   Other: Placebo Sponsor:   AVIR Green Hills Biotechnology AG Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we aimed to identify mutations related to mammalian adaptation of H9N2 influenza virus. We found that mouse-adapted viruses had several mutations in hemagglutinin (HA), PB2, PA, and PB1. Among the detected mutations, PB1-K577E was a novel mutation that had not been previously reported to involve mammalian adaptation. A recombinant H9N2 virus bearing only the PB1-K577E mutation showed enhanced pathogenicity in mice, with increased virus titers in nasal turbinates compared to that in mice infected with the wild-type virus. In addition, the PB1-K577E mutation increased virus polymerase activity in human cell cu...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, we generated VLPs containing hemagglutinin (HA), neuraminidase (NA) or M1 proteins derived from the A/California/04/09. Mice were immunized intramuscularly with HA-M1, NA-M1 or M1 VLPs and protective immunity was evaluated by assessing lung virus loads against low (5LD50) or high (100LD50) lethal dose of homologous virus challenges. High levels of virus-specific serum IgG antibody responses were induced in mice after HA-M1 VLPs immunization, whereas low or no IgG antibody responses were detected from immunization with NA-M1 VLPs or M1 VLPs, independently. Mice that were immunized with HA-M1 VLPs showed below...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
ConclusionPresence of the fosA3 gene on the same common plasmid as blaCTX-M-8 will have to be monitored. This draft genome provides data that will help in tracing the dissemination of this gene and the evolution of its plasmidic support.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsThe HIIT programmes showed improvements in the variables studied, with interventions two or three times weekly. Therefore, they can be used in schools, as a strategy to combat the childhood obesity pandemic and HIIT can be use alongside with existing PE activities within the same lesson or in specific periods during day school.
Source: Journal of Exercise Science and Fitness - Category: Sports Medicine Source Type: research
ConclusionsThe results of the review reaffirmedCampylobacter jejuni as the major trigger of GBS, whereas the association of influenza vaccines and GBS is less clear: Zika virus infection in association with GBS was found in only one study.This article is protected by copyright. All rights reserved.
Source: Tropical Medicine and International Health - Category: Tropical Medicine Authors: Tags: Systematic Review Source Type: research
This study carried out extensive molecular characterization of CTXФ and ToxT regulon in ctx+ve strains of V. mimicus isolated from the Bengal coast. Southern hybridization, PCR, and DNA sequencing of virulence related-genes revealed the presence of an El Tor type CTX prophage (CTXET) carrying a novel ctxAB, tandem copies of environmental type pre-CTX prophage (pre-CTXEnv), and RS1 elements, which were organized in an array of RS1-CTXET-RS1-pre-CTXEnv-pre-CTXEnv Additionally, a novel variant of tcpA and toxT respectively, showing phylogenetic lineage to a clade of V. cholerae non-O1/O139, was identified. The V. mimicus str...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Pseudomonas syringae is a widespread bacterial species complex that includes a number of significant plant pathogens. Amongst these, P. syringae pv. actinidiae (Psa) initiated a worldwide pandemic in 2008 on cult...
Source: BMC Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
(Natural News) When you think of a pandemic, global disease outbreaks like the Spanish flu that killed 50 million in the early 1900s or the more recent HIV/AIDS pandemic are what usually come to mind. However, some experts are warning that the next pandemic will come from an unexpected source – and it’s something that...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
USE OF EXTRACORPOREAL membrane oxygenation (ECMO) has increased dramatically in recent years. The use of ECMO catapulted around 2009 because of the following 3 major events: the global pandemic of the H1N1 influenza, the publication of the CESAR trial, and ongoing improvements in ECMO circuitry with polymethylpentene oxygenators and cannulae specifically designed for ECMO.1 As discussed by Ortoleva et al. in this issue of the Journal of Cardiothoracic and Vascular Anesthesia, the Extracorporeal Life Support Organization reported more than 10,000 ECMO cases in 379 centers in 2017.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
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