Historic flu is now worst in decades:10 more children dead

Acting CDC director Dr Anne Schuchat said on Friday that this season is as bad as the 2009 swine flu pandemic that killed 200,000 people and we may not have reached the peak yet.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 17 August 2018Source: Antiviral ResearchAuthor(s): Richa Sood, Naveen Kumar, Sandeep Bhatia, Khangembam Victoria Chanu, Chhedi Lal Gupta, Atul Kumar Pateriya, Anamika Mishra, Rekha Khandia, Namrata Mawale, Vijendra Pal SinghAbstractWe tested 65 highly pathogenic avian influenza (HPAI) A(H5N1) viruses, isolated from avian species in India between 2006 and 2015, for susceptibility to the FDA approved neuraminidase (NA) inhibitors (NAIs), oseltamivir and zanamivir using a phenotypic fluorescence-based assay. The overall incidence of resistant variants among HPAI A(H5N1) viruses was 7.69% (5/...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Influenza viruses A and B are important human respiratory pathogens causing seasonal, endemic and pandemic infections in several parts of the globe with high morbidity and considerable mortality. The current inactivated and live attenuated vaccines are not effective. Therefore, it is of interest to design universal influenza virus vaccines with high efficacy. The peptide GQSVVSVKLAGNSSL of pandemic influenza, the peptide DKTSVTLAGNSSLCS of seasonal influenza and the peptide DILLKFSPTEITAPT of influenza B were identified as potential linear cell mediated epitopes. The epitopes predicted by BepiPred (B-cell...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
(University of California - San Diego) In a pair of new modeling studies, researchers at University of California San Diego School of Medicine, with international colleagues, examined how policy reform in terms of drug decriminalization (in Mexico) and access to drug treatment (in Russia) might affect two regions hard hit by the HIV pandemic: Tijuana, Mexico and the Russian cities of Omsk and Ekaterinburg.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The development of a process map characterizing the landscape of US influenza virologic surveillance may help improve pandemic planning and response efforts.Emerging Infectious Diseases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
AbstractZika virus (ZIKV) is a flavivirus endemic in Africa and Southern Asian countries, which has recently emerged in unprecedented epidemic proportions around the world. Although ZIKV infection is often asymptomatic or distinguished by non-specific influenza-like symptoms, an increase in its pathogenicity and biological behavior has been the hallmark of the current pandemic. Increasing evidence suggests that neurotropic strains of ZIKV have evolved from less pathogenic strains of the virus. Neurological manifestations of ZIKV infection include a spectrum of congenital and non-congenital clinical entities, however visual...
Source: Journal of NeuroVirology - Category: Neurology Source Type: research
Publication date: September 2018Source: The Lancet Global Health, Volume 6, Issue 9Author(s): Lone Simonsen, Elizabeth Higgs, Robert J Taylor
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 10 August 2018Source: Trends in Endocrinology &MetabolismAuthor(s): Simon Lecoutre, Paul Petrus, Mikael Rydén, Christophe BretonAn adverse nutritional environment during the perinatal period increases the risk of adult-onset metabolic diseases, such as obesity, which may persist across generations. Adipose tissue (AT) from offspring of malnourished dams has been shown to display altered adipogenesis, lipogenesis, and adipokine expression, impaired thermogenesis, and low-grade inflammation. Although the exact mechanisms underlying these alterations remain unclear, epigenetic pro...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
ml;p MH Abstract With their ever-growing prevalence, obesity and diabetes represent major health threats of our society. Based on estimations by the World Health Organization, approximately 300 million people will be obese in 2035. In 2015 alone there were more than 1.6 million fatalities attributable to hyperglycemia and diabetes. In addition, treatment of these diseases places an enormous burden on our health care system. As a result, the development of pharmacotherapies to tackle this life-threatening pandemic is of utmost importance. Since the beginning of the 19th century, a variety of drugs have been evaluat...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rev Source Type: research
SUMMER in the UK could soon be coming to an end as the scorching heatwave gives way to damp grounds and grey skies and with it comes flu season. With a number of diseases such as Ebola gripping the world right now, how will the UK deal with a pandemic?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ton C Abstract An adverse nutritional environment during the perinatal period increases the risk of adult-onset metabolic diseases, such as obesity, which may persist across generations. Adipose tissue (AT) from offspring of malnourished dams has been shown to display altered adipogenesis, lipogenesis, and adipokine expression, impaired thermogenesis, and low-grade inflammation. Although the exact mechanisms underlying these alterations remain unclear, epigenetic processes are believed to have an important role. In this review, we focus on epigenetic mechanisms in AT that may account for transgenerational dysregul...
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Tags: Trends Endocrinol Metab Source Type: research
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