IDEA Trial Remakes Adjuvant Chemo in Colorectal Cancer IDEA Trial Remakes Adjuvant Chemo in Colorectal Cancer

Dr David Kerr on how one of the biggest studies at ASCO is already changing practice.Medscape Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

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This study demonstrated that CCAT1 exhibited pro-proliferative and pro-metastasis functions on FTC-133 cells and activated PI3K/AKT and MAPK signaling pathways via down-regulation of miR-143. These findings will provide a possible target for clinical treatment of thyroid cancer. PMID: 29791590 [PubMed - in process]
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
CONCLUSIONS: Initiatives emphasising the timeliness of diagnosis and treatment are reflected in the ways some patients experience their care. However, these accounts were open to further contextualisation about what speed of healthcare processes meant for evaluating the quality of their care. Healthcare professionals could therefore be an important patient resource in providing reassurance and support about the timeliness of diagnosis or treatment. PMID: 29784144 [PubMed - in process]
Source: European Journal of Oncology Nursing - Category: Nursing Authors: Tags: Eur J Oncol Nurs Source Type: research
The V600E BRAF mutation is associated with poorer prognosis and increased risk of recurrence in patients who have undergone resection of colorectal liver metastases (CRLM), according to a large cohort study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
CONCLUSIONS: Cadaveric training in D3EM was associated with progression in avoidance of vascular tears with no significant changes in operating time and lymph node harvest. PMID: 29791708 [PubMed - in process]
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
This study aimed to elucidate the therapeutic effects and ability of HLs to detect (diagnosis) cancer in an orthotopic graft mouse model of colorectal cancer with HCT116 cells for the use of HLs as theranostic agents. In the absence of a chemotherapeutic drug, HLs exhibited therapeutic effects by inhibiting the growth of HCT116 colorectal cancer cells in vitro, possibly through an increase in apoptosis. Intravenously administered HLs also caused a remarkable reduction in the relative cecum weight in an orthotopic graft mouse model of colorectal cancer. A decrease in tumor size in the cecal sections was confirmed by histolo...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Telomerase counteracts the telomere shortening that occurs with each round of cell division. In normal human cells, telomerase is repressed, leading to telomere shortening that triggers replicative senescence. However, in most tumors, telomerase is up-regulated and is essential for telomere maintenance and tumor cell growth. Although long considered a viable target for tumor therapy, successful inhibition of telomerase in cancer therapy remains to be described. In this issue of Genes &Development, Ahmed and Lingner (pp. 658–669) uncover a vulnerability in telomerase upon exposure of cancer cells to oxidative stre...
Source: Genes and Development - Category: Genetics & Stem Cells Authors: Tags: Cell Biology, Chromatin and Gene Expression Outlook Source Type: research
Current epidemiological data suggest that patients with diabetes, in particular type 2 diabetes, have an increased risk of developing different types of neoplasms. [1,2] In particular, higher incidence has been observed for breast [2 –4], endometrial [2,5,6], pancreatic, colorectal [2,4,7] and liver cancer. [2,7] Metformin has become one of the most widely used drugs in the treatment of type 2 diabetes mellitus (T2DM) and is the first-line therapy for patients with T2DM according to the American Diabetes Association/European A ssociation for Study of Diabetes guidelines.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Invited review Source Type: research
SIRT1, an NAD+-dependent histone/protein deacetylase, has diverse physiological actions. Recent studies have demonstrated that SIRT1 is overexpressed in colorectal cancer, suggesting its oncogenic potential. However, the molecular mechanisms by which overexpressed SIRT1 induces the progression of colorectal cancer and its inhibition remain largely unknown. Curcumin (diferuloymethane), a major component of the spice turmeric derived from the plant Curcuma longa L., has been reported to exert chemopreventive and anti-carcinogenic effects on colon carcinogenesis.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research
Molecules, Vol. 23, Pages 1271: Enzymatic Synthesis of a Novel Pterostilbene α-Glucoside by the Combination of Cyclodextrin Glucanotransferase and Amyloglucosidase Molecules doi: 10.3390/molecules23061271 Authors: José L. González-Alfonso David Rodrigo-Frutos Efres Belmonte-Reche Pablo Peñalver Ana Poveda Jesús Jiménez-Barbero Antonio O. Ballesteros Yoshihiko Hirose Julio Polaina Juan C. Morales María Fernández-Lobato Francisco J. Plou The synthesis of a novel α-glucosylated derivative of pterostilbene was performed by a transgly...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, we demonstrate that in FET and GEO colon cancer cells, knockdown of ezrin expression or inhibition of ezrin phosphorylation at Thr-567 increases apoptosis through protein kinase A (PKA) activation in a cAMP-independent manner. Transforming growth factor (TGF) β signaling inhibits ezrin phosphorylation in a Smad3-dependent and Smad2-independent manner and regulates pro-apoptotic function through ezrin-mediated PKA activation. On the other hand, ezrin phosphorylation at Thr-567 by insulin-like growth factor 1 receptor (IGF1R) signaling leads to cAMP-dependent PKA activation and enhances cell survival. Fur...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Cell Biology Source Type: research
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