Lab notes: Cheddar Man and Falcon X – not a crimefighting duo, but this week in science!

Where to even begin this week? Could it be with the news thathuman eggs have been developed in the lab for the first time? Or that researchers think they may have spotted a link between asparagine – a compound found in asparagus and other foods – and thespread of breast cancer? Maybe thatarchaeologists have discovered an exciting new Neolithic monument in Windsor? All of those things are certainly exciting, but really the two most thrilling stories this week are certainly Cheddar Man and Falcon Heavy: not a crimefighting duo but an exciting double-header of science and archaeology. Cheddar Man is Britain ’s oldest complete skeleton, and agroundbreaking analysis of his 10,000-year-old DNA has revealed that he had blue eyes, dark skin and dark curly hair, rather than the pale skin and fair hair that had always been assumed. By contrast, the incredible technological leap that has been made with thelaunch of Elon Musk ’s giant SpaceX rocket, and the safe return to Earth of at least two of three reusable rockets, promises a new new chapter in humankind ’s existence.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Source Type: news

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Research, published inMenopause, suggests that women who are not deficient in Vitamin D have a lower risk of developing breast cancer.MedicalXpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Publication date: November 2018Source: Biomedicine &Pharmacotherapy, Volume 107Author(s): Yu Lin, Xia Bai, Weina Zhou, Yulin He, Yiwei Wu, Xiangcheng WangAbstractOur present study confirmed radiation can promote the in vitro migration and invasion of triple negative breast cancer (TNBC) cells and increase the expression of epithelial–mesenchymal transition (EMT) related transcription factor ZEB1, while had no effect on Snail, Slug or Twist. Knockdown of ZEB1 attenuated radiation induced cell migration and invasion, suggesting that ZEB1 is essential for radiation induced progression of TNBC. Radiation increased th...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, miR-378a-3p enhanced the sensitivity of ovarian cancer cells to cisplatin through targeting MAPK1 and GRB2.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Four European patients developed breast cancer after receiving organs from the same donor, a case report explains.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Four European patients developed breast cancer after receiving organs from the same donor, a case report explains.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Authors: Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, Wu C, Zeng H, Liu Y Abstract [This corrects the article DOI: 10.18632/oncotarget.7583.]. PMID: 30220978 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Distribution and prognostic value of tumor‑infiltrating T cells in breast cancer. Mol Med Rep. 2018 Sep 05;: Authors: Meng S, Li L, Zhou M, Jiang W, Niu H, Yang K Abstract Tumor-infiltrating lymphocytes are associated with the response to neoadjuvent chemotherapy and prognosis in breast cancer. However, the distribution, interaction and prognostic value of tumor‑infiltrating T cells, the main component of the tumor microenvironment, have seldom been reported. In the present study, surgical specimens of 72 breast cancer patients were analyzed. Tumor‑infiltrating T cell subsets [cluster of differen...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Lee Y, Na J, Lee MS, Cha EY, Sul JY, Park JB, Lee JS Abstract Pristimerin, a quinonemethide triterpenoid, has demonstrated anticancer activity against a number of types of cancer, including breast cancer. However, its mechanism of action remains unclear. The present study investigated the autophagy‑induced anticancer efficacy of pristimerin on MDA‑MB‑231 human breast cancer cells. Pristimerin inhibited the growth of these cells in a concentration‑dependent manner. Treatment with pristimerin dose‑dependently induced an increase of light chain 3B (LC3‑II), whereas autophagy inhibitor 3‑methylad...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In conclusion, results of the present study demonstrated that LINC00978 exerts an oncogenic role in NSCLC by inhibiting miR‑6754‑5p expression. PMID: 30221669 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
(The North American Menopause Society (NAMS)) Vitamin D is already well known for its benefits in building healthy bones. A new study supports the idea that it also may reduce cancer risk as well as breast cancer mortality, especially in women with a lower body mass index. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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