Lab notes: Cheddar Man and Falcon X – not a crimefighting duo, but this week in science!
Where to even begin this week? Could it be with the news thathuman eggs have been developed in the lab for the first time? Or that researchers think they may have spotted a link between asparagine – a compound found in asparagus and other foods – and thespread of breast cancer? Maybe thatarchaeologists have discovered an exciting new Neolithic monument in Windsor? All of those things are certainly exciting, but really the two most thrilling stories this week are certainly Cheddar Man and Falcon Heavy: not a crimefighting duo but an exciting double-header of science and archaeology. Cheddar Man is Britain ’s oldest complete skeleton, and agroundbreaking analysis of his 10,000-year-old DNA has revealed that he had blue eyes, dark skin and dark curly hair, rather than the pale skin and fair hair that had always been assumed. By contrast, the incredible technological leap that has been made with thelaunch of Elon Musk ’s giant SpaceX rocket, and the safe return to Earth of at least two of three reusable rockets, promises a new new chapter in humankind ’s existence.Continue reading...
BREAST cancer is usually associated with women, but in rare cases, men can get it too. So how can men test for a cancerous lump? Look out for these signs and symptoms and follow these eight steps.
Christiana Neophytou, Panagiotis Boutsikos, Panagiotis Papageorgis
Do results of gene-expression profiles change whether patients with ER-positive breast cancer receive adjuvant chemotherapy?Journal of Clinical Oncology
Patients with ER-negative, but not ER-positive, isolated locoregional recurrence after unilateral breast cancer derive significant benefit from chemotherapy.
In this study, we have developed a facile approach for the fabrication of Tamoxifen citrate modified nanosized reduced graphene oxide (nano-rGO) with more stability and low cytotoxicity. The prepared nano-rGO sheets were characterized using HR-TEM and AFM imaging techniques. Further, the cytotoxicity was assessed using MTT assay on female BALB/c nude mice MCF-7 cell lines. In addition, by means of continuous-wave near-infrared laser, cancer cells in vivo were significantly ablated because of the photothermal effect stimulated by tamoxifen modified nano-rGO. These results indicated that the prepared tamoxifen modified nano-...
Nature Reviews Cancer 18, 136 (2018). doi:10.1038/nrc.2018.17 Author: Ulrike Harjes Mitogen- and stress-activated kinase 1 (MSK1) has been identified as an epigenetic modulator of luminal gene expression in breast cancer, maintaining latency of bone micrometastases.
c-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancerc-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancer, Published online: 22 February 2018; doi:10.1038/s41388-018-0165-8c-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancer
ConclusionsA small subset of pulmonary adenocarcinomas shows immunoreactivity for ER clones 6F11 and 1D5 in FNA samples (18.2% and 9.1%, respectively). The absence of immunoreactivity for ER‐SP1 clone indicates higher specificity of this clone in non‐breast tissue. The differential diagnostic value of all ER clones in malignant PEs appears to be secure. Larger studies are necessary to validate this observation.
Mari Lopez, who ran the food channel at home in Houston, Texas with her niece Liz Johnson, told viewers she had rejected traditional treatment for breast cancer in favor of a 90-day juice cleanse.
AbstractThe diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44 –67% at first lumbar puncture which increases to 84–91% upon second CSF sampling. Epithelial cell adhesion molecule (EpCAM) is expressed by solid tumors of epithelial origin like non-small-cell lung cancer, breast cancer or ovarium cancer. Recently, a CELLSEARCH® assay and flow cytometry laboratory techniques have been developed ...