' Game Changer': Treat Diabetes and Also Reduce CV Risk'Game Changer': Treat Diabetes and Also Reduce CV Risk

Drs Shubrook and Chamberlain discuss cardiovascular risk reduction associated with SGLT-2 inhibitors and GLP-1 agonists in T2D, and advise clinicians to'be aware. 'Medscape Family Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Commentary Source Type: news

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Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. N Engl J Med 2018;378:2275-87.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Current Best Evidence Source Type: research
This study examined the risk for postoperative complications, reoperations, and readmissions for patients with insulin-dependent diabetes mellitus (IDDM), patients with non-insulin-dependent diabetes mellitus (NIDDM), and patients without diabetes undergoing total joint replacements (TJRs). The American College of Surgeons National Surgical Quality Improvement Program database was queried for all primary TJRs in 2015. The study identified 78,744 TJRs (84.1% nondiabetic patients, 12.0% NIDDM, and 3.9% IDDM). Multiple logistic regression models identified IDDM as an independent risk factor for increased blood loss, myocardia...
Source: Journal of surgical orthopaedic advances - Category: Orthopaedics Tags: J Surg Orthop Adv Source Type: research
This study sought to characterize the changes in general immunity occurring during the progression from pre-diabetes to T2D. Male rats were fed a high-fat high-carbohydrate diet for 20 weeks (pre-diabetes induction period) and kept on the same diet being monitored for a further 12 weeks (experimental period). Blood was collected for haemocytometer analysis on week 0, 4, 8, and 12 of the experimental period after which the animals were sacrificed. Plasma was collected from centrifuged blood for ELISA (TNF-α, CRP, P-selectin, CD40 L, fibrinogen, and IL-6). Blood neutrophils percentage significantly...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
TYPE 2 diabetes sufferers are advised to cut down on the amount of sugar they consume in order to control the condition. It may seem sensible to replace sugar with sweetener, but artificial sweeteners have also proved somewhat controversial in the health world. So should diabetic people swap sugar for sweetener? One doctor explains.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: The knowledge of variants in taste, olfactory and texture related genes can contribute to the prevention of diseases related to unhealthy nutrition. Further studies would be useful to identify other variants in the genes involved in these systems. PMID: 30779105 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Hybrid procedures are safe and effective both in CLI patients with or without DM, and they should be taken into consideration whenever indications are present. PMID: 30779095 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Zhang SZ, Qiu XJ, Dong SS, Zhou LN, Zhu Y, Wang MD, Jin LW Abstract OBJECTIVE: Diabetic nephropathy (DN) is a major diabetic micro-vascular complication, and podocyte apoptosis induced by high glucose (HG) is a typical early feature of DN. Studies have shown that microRNAs (miRNAs) play a crucial role in the pathogenesis of DN. The purpose of the current study was to explore the role and molecular mechanism of miR-770-5p in podocyte apoptosis in DN. PATIENTS AND MATERIALS AND METHODS: In vitro podocyte model of DN was conducted by treatment conditionally immortalized mouse podocytes with HG (30 mM...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
AbstractAimTo describe how the group education process for people with type 2 diabetes is experienced by diabetes nurses and dietitians who support the patients ’ learning, in a primary care setting.DesignThe project took place at two primary care settings in the south of Sweden.MethodsData collected from focus ‐group interviews and reflection notes were subjected to phenomenological analysis.ResultsThe specially trained personnel experienced that group education made it possible for the patients to learn through reflection concerning their own and others ’ experiences. Furthermore, group education entailed i...
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractPurpose of ReviewDiabetes mellitus (DM) is highly prevalent among patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs). This review aims to summarize the available evidence on CTO recanalization in patients with DM.Recent FindingsCoronary artery bypass grafting (CABG) surgery is the recommended revascularization modality for patients with DM and multivessel coronary artery disease (CAD). However, the optimal management strategy in diabetic patients with CTO and single-vessel disease or prior CABG remains a clinical dilemma. Contemporary, large-scale, observational registr...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
ConclusionsSocial, food pattern, and physical activity were not associated with high blood glucose. In this study, we reported that male and female adults living in the urban area had a higher risk for high blood glucose compared with those who lived in rural area.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
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