Next Steps for Immunotherapies, Cell Therapies in Oncology Next Steps for Immunotherapies, Cell Therapies in Oncology

At ESMO 2017, Drs Zimmermann, Svane, and Coukos discuss successes and setbacks in immuno-oncology.Medscape Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

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Researchers believe an assay may be used to detect and monitor dynamics of genetic mutations of patients treated with immunotherapy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
The STRIvE-01 study explored the safety of CAR T-cell therapy in children and young adults with relapsed or refractory solid tumors.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
This article provides an overview of AZD1775, based on English peer-reviewed articles on MEDLINE. The authors highlight the data from the published preclinical and clinical studies. Expert opinion: A majority of the current clinical trials focus on AZD1775 combined with chemotherapy or radiation. Treatment with AZD1775 was tolerated and antitumor activity has been observed, especially in patients with advanced malignancies harboring G1 checkpoint aberrations and/or DNA damage repair defects. Thus, identification of the molecular subtypes that benefit most from the treatment with AZD1775 alone or in combination may provide ...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Dr Jing Pan, of Beijing Boren Hospital, Beijing, P.R. China, discusses a new anti-CD22 CAR T-cell immunotherapy for pediatric relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). Dr Pan ex... Author: VJHemOnc Added: 08/15/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
One of the major downsides to immunotherapy is its high cost. In this interview, Rafael Fonseca, MD, of the Mayo Clinic, Phoenix, AZ, discusses whether it is cost-effective for patients to receive mon... Author: VJHemOnc Added: 08/15/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Publication date: Available online 15 August 2018Source: Pharmacological ResearchAuthor(s): Robert RoskoskiAbstractThe Ras-Raf-MEK-ERK signal transduction cascade is arguably the most important oncogenic pathway in human cancers. Ras-GTP promotes the formation of active homodimers or heterodimers of A-Raf, B-Raf, and C-Raf by an intricate process. These enzymes are protein-serine/threonine kinases that catalyze the phosphorylation and activation of MEK1 and MEK2 which, in turn, catalyze the phosphorylation and activation of ERK1 and ERK2. The latter catalyze the regulatory phosphorylation of dozens of cytosolic and nuclear...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: September–October 2018Source: Journal of the American Society of Cytopathology, Volume 7, Issue 5Author(s): Maryan Shabihkhani, Weiming Yang, Minghui Ao, Edward Gabrielson, Frederic Askin, Hui Zhang, Q. Kay Li
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Publication date: September–October 2018Source: Journal of the American Society of Cytopathology, Volume 7, Issue 5Author(s): Jordan Reynolds, Longmei Zhao
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
araman Ö, Uzuner N Abstract Işık S, Çağlayan-Sözmen Ş, Asilsoy S, Kılıçarslan SK, Anal Ö, Karaman Ö, Uzuner N. Knowledge levels related to allergen specific immunotherapy and perspectives of parents whose children were diagnosed with asthma and/or allergic rhinitis in Turkey. Turk J Pediatr 2018; 60: 50-55. In the present study, we aimed to evaluate the knowledge levels and perspectives about allergen specific immunotherapy (ASI) of parents whose children were diagnosed with asthma and/or allergic rhinitis with positive skin prick test. The study was conducted between Septem...
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
(NIH/National Cancer Institute) Steven A. Rosenberg, M.D., Ph.D., of the Center for Cancer Research (CCR) at the National Cancer Institute (NCI), has been named a recipient of the 2018 Albany Medical Center Prize in Medicine and Biomedical Research for his leading role in the development of immunotherapy to treat cancer. Dr. Rosenberg will share the honor with fellow immunotherapy researchers James P. Allison, Ph.D., and Carl H. June, M.D.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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