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Bone tissue grown in the lab used to repair damaged leg

The experimental tissue-engineering technology is being developed by Bonus BioGroup of Haifa, Israel, using fat cells extracted from a patient used to grow bones on a biological scaffold.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In conclusion, the connection between DNA damage and aging is emphasized by the secretion of senescence-associated proteins during cellular senescence, a phenotype which is activated by DNA damage and is common for both human and mice. Though much progress has been achieved, full understanding of these mechanisms has still a long way to go. XPO1 as a Novel Target for Therapies to Enhance Autophagy https://www.fightaging.org/archives/2018/05/xpo1-as-a-novel-target-for-therapies-to-enhance-autophagy/ Autophagy is the name given to a collection of cellular housekeeping processes that recycle damaged and un...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionThis study demonstrated that intravenous dexmedetomidine during hernia repair with local anesthesia is safe and the results were satisfactory to both operators and patients.
Source: Hernia - Category: Sports Medicine Source Type: research
ConclusionThe presented missions contribute significantly to an improvement in local healthcare and decrease the burden of disease. We were able to show the sustainable character of these surgical missions. As a next step, we will analyse the cost-effectiveness of MSTs.
Source: Hernia - Category: Sports Medicine Source Type: research
CONCLUSION: The present review elucidates the effect of IR on various oncogenic RTKs and their mechanisms, downstream signaling, intracellular translocations, their role in the repair of radiation-induced DNA damage and post-irradiation survival. Based on the knowledge derived from RTK biology and the analysis of relevant clinical trials, this review attempts to identify radiobiological considerations, which could be implemented in future trials, combining radiotherapy with RTK-antagonist. Additionally, we identify the radiosensitizing potential of recently-developed RTK-targeted nanoformulations. This review would probabl...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
ConclusionThis novel stress methodology allows for sport-specific imaging, which is ideal for determining functional compromise of the hand ’s pulley mechanism. Surgical outcomes may be more sensitively compared when using stress views, and these comparisons may then direct optimal repair technique. Future studies will utilize this technique to attempt early-stage detection of pulley injuries prior to complete rupture.
Source: Skeletal Radiology - Category: Radiology Source Type: research
Source: Brazilian Journal of Cardiovascular Surgery - Category: Cardiology Source Type: research
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
In this study, we assessed the effect of AZD1775 on endometrial and ovarian cancer cells in the presence of two DNA damaging agents, the PARP1 inhibitor, olaparib, and the chemotherapeutic agent, gemcitabine. We show that AZD1775 alone is effective as a therapeutic agent against some p53 mutated cell models. Moreover, the combination of AZD1775 with olaparib or gemcitabine is synergistic in cells with mutant p53 and constitutes a new approach that should be considered in the treatment of advanced and recurrent gynecologic cancer.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Many previous studies have evaluated the outcomes of open and endovascular repair of thoracoabdominal aortic aneurysms (TAAAs). However, little is known about the differences in cost of these procedures and the potential factors driving these differences. The aim of this study was to evaluate the outcomes and cost of open aortic repair (OAR) vs endovascular repair of intact TAAA.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Wound Repair and Regeneration, EarlyView.
Source: Wound Repair and Regeneration - Category: Surgery Authors: Source Type: research
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