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Bone tissue grown in the lab used to repair damaged leg

The experimental tissue-engineering technology is being developed by Bonus BioGroup of Haifa, Israel, using fat cells extracted from a patient used to grow bones on a biological scaffold.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Zarei F, Soleimaninejad M Abstract Wound healing is a biological complex process that involves several cell types under the control and regulation of several growth factors and cytokines. There have been efforts to study the therapeutic effects of granulocyte-macrophage colony-stimulating factor, platelet-derived growth factor, transforming growth factor-β, vascular endothelial growth factor and basic fibroblast growth factor on chronic wounds. In addition, the effects of biomaterials such as nano-fibrous chitin and chitosan have been proven to be effective on wound healing. Furthermore, stem cell the...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
CONCLUSIONS: The randomized controlled trial demonstrates that SRBS for renorrhaphy during retroperitoneal laparoscopic partial nephrectomy is safe and efficient. Application of barbed suture simplifies the parenchymal repair procedure and reduces warm ischemia time in comparison with conventional suture. PMID: 29448861 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
This study details the characterization of a mouse rotator cuff explant culture model, including bone, tendon, and muscle (BTM). Following harvest, BTM explants were maintained in stress-deprived culture for one week and tendon was then assessed for changes in cell viability, metabolism, matrix structure and content. Matrix turnover occurred throughout culture as manifested in both gene expression and biosynthesis, but this did not translate to net changes in total collagen or sulfated glycosaminoglycan content. Furthermore, tendon structure was not significantly altered throughout culture. However, we found significant ce...
Source: Connective Tissue Research - Category: Research Tags: Connect Tissue Res Source Type: research
Publication date: Available online 17 February 2018 Source:The Lancet Author(s): Frederik Helgstrand, Thue Bisgaard
Source: The Lancet - Category: General Medicine Source Type: research
In this study we aimed to investigate whether use of a mesh was better in reducing recurrence compared with suture repair for smaller umbilical hernias. Methods We did a randomised, double-blind, controlled multicentre trial in 12 hospitals (nine in the Netherlands, two in Germany, and one in Italy). Eligible participants were adults aged at least 18 years with a primary umbilical hernia of diameter 1–4 cm, and were randomly assigned (1:1) intraoperatively to either suture repair or mesh repair. In the first 3 years of the inclusion period, blocked randomisation (of non-specified size) was achieved by an envelope ran...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 16 February 2018 Source:Pharmacological Research Author(s): Harald Hampel, Andrea Vergallo, Lisi Flores Aguilar, Norbert Benda, Karl Broich, A. Claudio Cuello, Jeffrey Cummings, Bruno Dubois, Howard J. Federoff, Massimo Fiandaca, Remy Genthon, Marion Haberkamp, Eric Karran, Mark Mapstone, George Perry, Lon S. Schneider, Lindsay A. Welikovitch, Janet Woodcock, Filippo Baldacci, Simone Lista The complex multifactorial nature of polygenic Alzheimer’s disease (AD) presents significant challenges for drug development. AD pathophysiology is progressing in a non-linear dynamic fashion acr...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: May 2018 Source:Journal of Neurolinguistics, Volume 46 Author(s): Srđan Popov, Roelien Bastiaanse In the current experiment, participants read word-by-word sentences containing gender (adjective-noun) and number (article-noun) disagreement in Dutch while EEG was recorded. Number and gender disagreement were expected to elicit different responses due to several reasons. Firstly, gender is a lexical feature whose value (e.g., masculine or feminine) is stored in the lexicon, whereas number value is assigned depending on conceptual knowledge (numerosity). Also, Dutch marks number but not gender on the noun....
Source: Journal of Neurolinguistics - Category: Speech-Language Pathology Source Type: research
This study investigates the effect of Dicer, an enzyme responsible for microRNA maturation, on limb development and regeneration in Xenopus. Dicer is expressed in the developing Xenopus limbs, and is upregulated after limb amputation during both regeneration‐competent and ‐deficient stages of tadpole development. Inactivation of Dicer in early (NF stage 53) tadpole limb buds leads to shorter tibulare/fibulare formation, but does not affect limb regeneration. However, in late stage, regeneration‐deficient tadpole limbs (NF stage 57), Dicer inactivation restores the regeneration blastema, and stimulates limb regenerati...
Source: Wound Repair and Regeneration - Category: Surgery Authors: Tags: Original Research ‐Regeneration Science Source Type: research
Hepatic ischemia reperfusion (I/R) injury is a major complication of severe hypotension followed by fluid resuscitation, liver resection, and liver transplantation [1]. Hepatic I/R injury followed by hepatic tissue repair significantly affects post-operative liver function and survival, since insufficient liver restoration is associated with increased morbidity and mortality [2,3]. Thus, the balance between hepatocyte death and subsequent liver repair and regeneration determines the prognosis of patients with hepatic I/R injury.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
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Source: Clinical and Experimental Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
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