Role for Cela1 in Postnatal Lung Remodeling and AAT-deficient Emphysema.

CONCLUSIONS: Cela1 is important in physiologic and pathologic stretch-dependent remodeling processes in the postnatal lung. AAT is an important regulator of this process. Our findings provide proof-of-concept for the development of anti-Cela1 therapies to prevent and/or treat AAT-deficient emphysema. PMID: 29420065 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29420065?dopt=Abstract

Source: Am J Respir Cell Mol... - February 8, 2018 Category: Respiratory Medicine Authors: Joshi R, Heinz A, Fan Q, Guo S, Monia B, Schmelzer CEH, Weiss AS, Batie M, Parameshwaran H, Varisco BM Tags: Am J Respir Cell Mol Biol Source Type: research