Exclusive: Nurses set to lead ‘revolution’ in haemophilia care
Nursing is set to be at the forefront of “revolutionary” changes in haemophilia care, but the profession still carries a burden of “guilt” from the contaminated blood scandal that saw hundreds of NHS patients infected with HIV and hepatitis C, according to a leading specialist nurse.
Semin Liver Dis 2018; 38: 112-120 DOI: 10.1055/s-0038-1655774Chronic infection with the hepatitis C virus (HCV) has long been the dominant complication of substitution therapy in patients with inherited blood disorders and the cause of anticipated death due to end-stage liver disease. In hemophilia, transmission of HCV with clotting factors concentrates started to be curbed in the mid-1980s following the adoption of procedures of virus inactivation of concentrates based on heat, whereas in the 1990s treatment of HCV infection with interferon monotherapy was attempted, however, with little success. The advent of combination...
Conclusions: Our data identified some effects of the long-term treatment on total HIV DNA levels and highlighted the partial influence of comorbidities and coinfections. Total HIV DNA monitoring contributed to therapy response estimates and HIV reservoir quantification. The results suggest that HIV DNA monitoring during ART might be useful as a persistence marker in both HIV-monoinfected patients and those with comorbidities and coinfections.
The latest inquiry must discover how thousands of haemophiliacs contracted HIV or hepatitis C from blood products, and why it was covered up for so longIn two weeks ’ time Sir Brian Langstaff will take up his post as chair of thepublic inquiry into contaminated blood and contaminated blood products. Today, World Haemophilia Day, is the perfect occasion to remind Langstaff what the thousands of haemophiliac victims need from this inquiry if they are to get justice.In the 1970s and 1980s more than 4,600 haemophiliacs contracted HIV or hepatitis C after being infected by contaminated blood-clotting products. Much of the...
In the 1970s and 80s, 4,689 British haemophiliacs were treated with contaminated blood products. So far, more than half of them have died. The government knew there were risks involved. The patients didn ’t. Will they ever get justice?It has been called the biggest treatment disaster in the history of the NHS, and a “horrific human tragedy”. But Su Gorman, whose husband has endured years of ill health as a result of haemophilia treatment, does not believe this adequately describes Britain’s contaminated blood scandal. As far as she is concerned, it is simply a crime.In the 1970s and 80s, 4,689 haemo...
We report the first case of ankle arthroscopic arthrodesis in a patient with haemophilia B after undergoing living donor liver transplantation. We carefully monitored the patient's factor IX (FIX) plasma levels during his perioperative period, and we successfully performed his arthroscopic ankle arthrodesis without administration of any additional FIX concentrates. Our case has demonstrated the feasibility of joint surgery after liver transplantation without administration of additional clotting factors while monitoring FIX activity.
ConclusionsCerebral microbleeds (CMBs) are common in adults with haemophilia, but not clearly more prevalent than in haemostatically normal controls. In PWH, older age, HCV infection, CV risk factors, and the presence of an inhibitor were associated with CMBs. Large CMBs and multiple CMBs may be more prevalent in PWH than in the general population. The clinical impact of CMBs in PWH requires further study.
CONCLUSIONS: The results of this study showed a low frequency of T. cruzi infection in multitransfused patients, suggesting that the risk of transfusion infection in Colombia is low. Known risk factors for transfusion-related infection were not associated with the presence of anti-T. cruzi antibodies. PMID: 28968013 [PubMed - in process]