Two Drugs (#Apalutamide and #Enzalutamide) Offer Hope Against a Tough-to-Treat Prostate Cancer

THURSDAY, Feb. 8, 2018 -- Two cancer drugs can stall the progression of a particularly hard-to-treat form of prostate cancer, a pair of new trials shows. Both a newly developed drug called apalutamide and an already approved drug called...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Use alongside traditional treatment in advanced cases ‘could benefit 3,000 men in UK’Radiotherapy could increase the chances of survival for thousands of men with prostate cancer that has already spread by the time they are diagnosed, new research suggests.Prostate cancer is the most common cancer to affect men in the UK. About 47,000 are diagnosed every year and around 11,500 die. Significant numbers of men are not diagnosed until the cancer has spread, which reduces their chances of survival.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Prostate cancer Men Health Life and style Society Medical research Science UK news Source Type: news
CONCLUSIONS: MicroRNA-19a-3p inhibits migration, invasion and EMT of PCa cells via inhibiting SOX4. PMID: 30338791 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Downregulated microRNA-373-3p promoted the proliferation of prostate cancer cells via targeting AKT1. PMID: 30338790 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Brandi F, Grupp K, Hube-Magg C, Kluth M, Lang D, Minner S, Möller-Koop C, Graefen M, Heinzer H, Tsourlakis MC, Wittmer C, Jacobsen F, Huland H, Steurer S, Lebok P, Hinsch A, Wilczak W, Schlomm T, Simon R Abstract Approximately 50% of prostate cancer types harbor the transmembrane protease, serine 2: Erythroblast transformation-specific-related gene (ERG) fusion, resulting in oncogenic expression of the ERG transcription factor. ERG represents an attractive target for potential future anticancer therapy in advanced and metastatic prostate cancer. To better understand whether the analysis of the primary...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chida K, Hakuno F, Takahashi SI Abstract Insulin-like growth factors (IGFs) have been shown to induce proliferation of many types of cells. Insulin receptor substrates (IRSs) are major targets of IGF-I receptor (IGF-IR) tyrosine kinase activated by IGFs, and are known to play important roles in the activation of downstream signaling pathways, such as the Erk1/2 pathway. Dysregulation of IGF signaling represents a central tumor promoting principle in human carcinogenesis. Prostate...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Gaur S, Lay N, Harmon SA, Doddakashi S, Mehralivand S, Argun B, Barrett T, Bednarova S, Girometti R, Karaarslan E, Kural AR, Oto A, Purysko AS, Antic T, Magi-Galluzzi C, Saglican Y, Sioletic S, Warren AY, Bittencourt L, Fütterer JJ, Gupta RT, Kabakus I, Law YM, Margolis DJ, Shebel H, Westphalen AC, Wood BJ, Pinto PA, Shih JH, Choyke PL, Summers RM, Turkbey B Abstract For prostate cancer detection on prostate multiparametric MRI (mpMRI), the Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) and computer-aided diagnosis (CAD) systems aim to widely improve standardization across radiologis...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ConclusionsThe community raw incidence rate was higher than most existing data. We observed significant differences among the various geographical areas, which could be explained mainly by the age distribution and the opportunistic screening policies for each area.ResumenObjetivoConocer la incidencia real de cáncer de próstata (CP) en las áreas sanitarias de Castilla y León en el año 2014.Material y métodosEstudio multicéntrico en el que participan 7 de las 9 áreas sanitarias de Castilla y León. Se recogen datos con carácter retrospectivo que incluyen el...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Authors: Braczkowski RS, Kwiatkowski R, Danikiewicz A, GórczyƄska-Kosiorz S, Trautsolt W, Braczkowska B, Grzeszczak W Abstract Prostate cancer (PC) is the most common cancer among men worldwide and its pathogenesis is complex. The development of PC depends on family and environmental factors. Vitamin D can be associated with both of these factors. Its reduced serum concentration has been reported in a number of tumors. However, in the case of PC, the study results are conflicting. Polymorphism of VDR gene may also be involved in the development of this cancer. The aim of the study was to compare the frequen...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
The objective of this study was to observe the migration of the pathological stages from radical prostatectomy (RP) over 10 years in France through 2 French centers. METHODS: It was a multicentric retrospective study, where all the RP realized in 2 French tertiary centers, in a laparoscopic or retropubic approach for each of the years 2005, 2010 and 2015 were included. Preoperative data (age, PSA, clinical stage, number of positive biopsies, Gleason biopsy score) and postoperative data (pTNM, pathological Gleason score (pGS)) were analyzed and compared. RESULTS: In all, 1282 RP were realized (503 in 2005, 403 in 20...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Details of the study that led to the restriction of the indication for the radiopharmaceutical radium-223 in prostate cancer have now been reported, and that restriction is questioned.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
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