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Prognosis comparisons in acute ischemic stroke patients with thrombolysis and nonthrombolysis therapy: a retrospective study with larger sample size

We compared the short-term, middle-term and long-term primary outcomes between thrombolysis and nonthrombolysis therapy in acute ischemic stroke (AIS) patients. Medical records were collected from patients suffered from AIS between 2010 and 2013 and allocated into either the intravenous recombinant tissue plasminogen activator (as rt-PA group) treatment, or non-rt-PA treatment group (as control group). The primary outcomes included a proportion of patients with favorable outcome [as defined with a modified Rankin Scale (mRS) of 0–1], functional independence (mRS of 0–2) or with bad outcome (mRS of 5–6) at 3, 6 and 12 months and the overall mortality. The secondary outcome included the events of intracranial hemorrhage. A total of 357 patients from Xinhua Hospital were selected. At 3-month follow-up, 86 patients in rt-PA vs. 99 in control group had favorable outcome, 105 vs. 122 were independent and 23 vs. 27 had bad outcome. At 6-month follow-up, 101 patients in rt-PA vs. 104 in control group had favorable outcome, 114 vs. 124 were independent and 20 vs. 34 had bad outcome. At 12 months, 104 patients in rt-PA vs. 105 in control group had favorable outcome, 117 vs. 125 were independent and 12 vs. 32 had bad outcome. At the end of 12 months, more deaths occurred in control group (20) than in the rt-PA group (11), but it was not statistically significant. Alteplase treatment in AIS patients showed the superior primary outcomes compared with control group, espec...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: Original Articles Source Type: research

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Authors: Hanefeld C, Haschemi A, Lampert T, Trampisch HJ, Mügge A, Miebach J, Kloppe C, Klaaßen-Mielke R Abstract BACKGROUND: Persons of lower socio-economic status are at higher risk of disease, especially with respect to severe and chronic illnesses. To date, there have not been any studies with large case numbers regarding acute medical emergencies in this population. METHODS: In a retrospective study, data were obtained on all cases treated by emergency physicians in Bochum, Germany, in 2014/2015, including the diagnoses that were made by the emergency physicians. There were a total of 16 767 cas...
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Publication date: 21 February 2018 Source:The Lancet, Volume 391, Supplement 2 Author(s): Amir Abukaresh, Rami Al-Abadlah, Bettina Böttcher, Khamis El-Essi Background In the 2014 Palestinian annual health report, cerebrovascular accident was ranked as the third leading cause of death in the occupied Palestinian territory. Cerebrovascular accident is also one the most common causes of disability worldwide. Good management decreases mortality and morbidity. The aim of this study was to assess the current management of patients with ischaemic stroke at the Al-Shifa Hospital and to compare this with international guideli...
Source: The Lancet - Category: General Medicine Source Type: research
AbstractBackgroundNon-vitamin K antagonist oral anticoagulants (NOACs) have gained increasing importance for stroke prevention in patients with non-valvular atrial fibrillation (AF). With changing prescription practice, among other factors, clinicians can expect to see rising numbers of patients with ischemic stroke and pre-existing NOAC therapy. Few data exist regarding a potential impact of NOAC on stroke severity and outcome.AimsTo evaluate the impact of pre-admission NOAC therapy on ischemic stroke severity.MethodsRetrospective analysis of medical data of 376 patients with newly detected AF or known AF with either no p...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
Conclusions: Stent placement for treatment of carotid webs can be performed safely. Further studies are needed to confirm our findings.Intervent Neurol 2018;7:233 –240
Source: Interventional Neurology - Category: Neurology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
DESPITE SIGNIFICANT IMPROVEMENTS in the management of patients with cardiovascular disease, stroke remains the second leading cause of death worldwide.1 Ischemic strokes account for 87% of all strokes, whereas 10% result from intracerebral hemorrhage, and 3% are subarachnoid hemorrhage strokes.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Ischemic strokes can induce cardiac structural and functional damage. Essentially stroke-induced heart injury (SIHI) is part of a wider spectrum of brain injuries (eg, cerebral infarction, intracranial hemorrhage) leading to heart disease, known as neurogenic heart disease. Similarly, the concept of atrial fibrillation (AF) diagnosed after stroke (AFDAS) was established to reflect the complexity of this specific type of AF that is unknown until the time of stroke [1]. The detection of AF after ischemic stroke is usually regarded as the cause of the stroke (cardiogenic AFDAS).
Source: Journal of Electrocardiology - Category: Cardiology Authors: Tags: Editorial Article Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Condition:   Patients (>=65 Years Old) Suffering From Mild-moderate Stroke (Ischemic or Hemorrhagic, Stroke Severity Assessed by NIHSS
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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