An ex-vivo model of shear-rate-based activation of blood coagulation
The study presents a model of shear-stress-based platelet activation. Twenty-eight patients (22 free from anticoagulants and major antiplatelet agents, and six under the effects of P2Y12 platelet inhibitors) participated. The main purpose was to verify the hypothesis that a model of shear-dependent blood activation does not require artificial activators to trigger clot formation. Whole blood collected from the patients received platelet function tests [ADPtest and thrombin receptor-activating peptide (TRAP)test] and was tested with a cone-on-plate viscosimeter at a shear rate of 100 s−1. Changes in blood viscosity were characterized by a time-to-gel point (TGP), a maximum clot viscosity and a steady clot viscosity (SCV). In patients free from major antiplatelet effects, the TGP was 180 s (interquartile range 148–290 s), while in patients under double antiplatelet therapy the TGP was significantly (P = 0.039) longer (345 s, interquartile range 250–452 s). The SCV was 16 centipoise (cP) (interquartile range 11–47 cP) in the patients free from major antiplatelet agents, significantly (P = 0.012) higher than in patients under double antiplatelet therapy (10 cP, interquartile range 6–11 cP). There was a significant (P = 0.011) association between platelet function at the TRAPtest and the maximum clot viscosity, and between TRAPtest and the SCV (P = 0.021). A shear rate of 100 s−1 triggers clot formation through ...
In this study, the peel, pulp, and seeds of Vitis labrusca L. grapes were characterized by LC-DAD and ICP OES and changes in polyphenols, macro- and microelements were monitored using simulated human digestion. The pulp and seeds were characterized by flavanols, and the peels were high in phenolic acids. After the digestion, the highest bioaccessibility was found for quercetin (85%), while anthocyanins diglucosides were more bioaccessible in the gastric phase (153% and 113% for malvidin and cyanidin, respectively). The digestion of grape peels resulted in higher bioaccessibility of most minerals, suggesting the nutritional...
This study examines the usefulness of ferrosilicon as a candidate feedstock material for wire-based 3D printers designed for in-space manufacturing. Alloys of composition ranging from pure iron to 12 wt% Si were synthesized and their electrical and mechanical properties characterized. The melts were cast into rods for mechanical testing to determine ultimate strength and ductility. It was determined that the samples above 3 wt% Si were too brittle to be pulled into wire and ruptured at low strain values. The 3 wt% Si sample and iron had comparable mechanical properties relative to samples of higher silicon content but with...
Naveen Elangovan, Paul J. Tuite, J ürgen Konczak
Christian Schlenstedt, Steffen Paschen, Jana Seuthe, Jan Raethjen, Daniela Berg, Walter Maetzler, G ünther Deuschl
ConclusionThis novel service met all criteria of safety and was effective in reducing frequency of seizures. Patients preferred it to conventional services. It should be transferable to other LMICs.
Publication date: Available online 10 December 2018Source: The LancetAuthor(s): Felix Greaves, Indra Joshi, Mark Campbell, Samantha Roberts, Neelam Patel, John Powell
Publication date: Available online 9 December 2018Source: The LancetAuthor(s): The Lancet
Publication date: Available online 9 December 2018Source: The LancetAuthor(s): Lawrence O Gostin, Benjamin M Meier, Rebekah Thomas, Veronica Magar, Tedros A Ghebreyesus