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Pruritic arthropod bite ‐like papules in T‐cell large granular lymphocytic leukaemia and chronic myelomonocytic leukaemia

We report the extraordinary case of a patient with MDS who developed T‐LGLL, and subsequently the MDS progressed to CMML. The patient then developed diffuse arthropod bite‐like papules and intractable pruritus.
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Concise Report Source Type: research

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Authors: Gale RP, Hochhaus A Abstract Chronic myeloid leukemia (CML) can be cured using tyrosine kinase-inhibitors (TKIs) when cure is defined as achieving a life-expectancy similar or even better than sex- and age-matched persons without CML. Most deaths in persons with CML are now from non-leukemia-related causes including heart disease, diabetes other cancers and stroke. Contrary to expectation, 40-50 percent of persons with CML treated for a few years with TKIs and who achieve a deep molecular response can stop TKI-therapy without leukemia recurrence for several years, some possibly indefinitely. Consequently, ...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Sjögren's Disease Associated with Severe Retinal Vasculitis and/or Necrotizing Scleritis: Two Cases. Klin Monbl Augenheilkd. 2018 Feb 16;: Authors: Lopez Baumann S, Borgeat Kaeser A, Valerio F, Spertini F, Guex-Crosier Y PMID: 29452446 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Authors: Liu Y, Chen X, Han W, Zhang Y Abstract On August 30, 2017, the U.S. Food and Drug Administration (FDA) approved Novartis' tisagenlecleucel (CTL-019, Kymriah), which is a synthetic bioimmune product of anti-CD19 chimeric antigen receptor (CAR) T cells, for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). This was a milestone in tumor immunology on account of the significant antitumor effect of tisagenlecleucel for the treatment of relapsed/refractory B-ALL patients. Conventional standard therapies for B-ALL have high failure rates, thus developing new therapies is crucial fo...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
We present the case of a 81 years old women previously treated for cervix carcinoma showing later a stomach metastasis. The patient is alive and disease free 39 months after salvage gastrectomy. A radical surgery in selected patients could be useful for symptom palliation and prolonged survival. PMID: 29449732 [PubMed - in process]
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
AbstractSeminomas are the most frequent testicular tumors and in spite of specific markers some histological subtypes can be diagnostically challenging due to the potential overlap of morphologic features and a variant antigen expression. Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase present in hematogones, thymic T cells, lymphoblastic lymphoma/leukemia (LBL), and in some cases of acute myeloid leukemia but so far has not been described to be expressed in seminomas. After observing a reactivity of TdT in one case of seminoma, we analyzed ten additional tumors by immunohistochemistry to determine their sp...
Source: Virchows Archiv - Category: Pathology Source Type: research
Conclusion Haematological malignancies in the Eastern Cape Province show disparities in gender and pathology-specific incidence patterns. The present study suggest that haematological malignancies are not uncommon in this region and the incidence rate of at least one rare subtype, APL, is comparable with some European populations.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionsIn the present study, we show that the renal lymphocytic organisation is associated with renal outcome in ANCA‐associated GN. The organisation of the lymphocytic infiltrate may be a morphologic correlate of a perpetual and exaggerated inflammation in renal ANCA disease. Classifying the lymphocytic infiltrate could help predict renal outcome, and might therefore be used for individualised adjustments in the intensity and duration of immunosuppressive therapy.This article is protected by copyright. All rights reserved.
Source: Histopathology - Category: Pathology Authors: Tags: Original Article Source Type: research
Source: Leukemia Research - Category: Hematology Source Type: research
ConclusionCollectively, our data reveal that alteration of erythrocyte sialylation status by bacterial neuraminidase favors eryptotic cell death, an effect potentially contributing to reduced erythrocyte lifespan and anemia in sepsis.This article is protected by copyright. All rights reserved.
Source: European Journal of Haematology - Category: Hematology Authors: Tags: Original Article Source Type: research
Authors: Ripollés-Melchor J, Carli F, Coca-Martínez M, Barbero-Mielgo M, Ramírez-Rodríguez JM, García-Erce JA Abstract In the era of perioperative medicine, important advances have been made in the perioperative care of patients, usually within those known as Enhanced Recovery After Surgery (ERAS) protocols. These have led to a decrease in postoperative complications and the duration of hospital stays; however, there is still a lack of preoperative care, which could make perioperative medicine more prominent. Elderly patients, malnourished, anaemic and ones with a low physical fun...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
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