The daily lives of people with Parkinson's disease.

This study assists the improvement of care to people with the disease, because the care practice emerges from the interactions between the subjects. PMID: 29412283 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research

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(MedPage Today) -- News and commentary from the world of neurology and neuroscience
Source: MedPage Today Neurology - Category: Neurology Source Type: news
Molecules, Vol. 24, Pages 305: Cell Responses to Extracellular α-Synuclein Molecules doi: 10.3390/molecules24020305 Authors: Alexei A. Surguchev Fatemeh Nouri Emamzadeh and Andrei Surguchov Synucleins are small naturally unfolded proteins involved in neurodegenerative diseases and cancer. The family contains three members: α-, β-, and -synuclein. α-Synuclein is the most thoroughly investigated because of its close association with Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Until recently, the synuclein's research was mainly focused on their ...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
The Parkinson's disease-associated protein kinase PINK1 and ubiquitin ligase Parkin coordinate the ubiquitination of mitochondrial proteins, which marks mitochondria for degradation. Miro1, an atypical GTPase involved in mitochondrial trafficking, is one of the substrates tagged by Parkin after mitochondrial damage. Here, we demonstrate that a small pool of Parkin interacts with Miro1 before mitochondrial damage occurs. This interaction does not require PINK1, does not involve ubiquitination of Miro1 and also does not disturb Miro1 function. However, following mitochondrial damage and PINK1 accumulation, this initial pool ...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Autophagy & Cell Death, Membrane & Intracellular Transport Articles Source Type: research
We report that following mitochondrial damage-induced mitophagy, Parkin directly ubiquitinates the apoptotic effector protein BAK at a conserved lysine in its hydrophobic groove, a region that is crucial for BAK activation by BH3-only proteins and its homo-dimerisation during apoptosis. Ubiquitination inhibited BAK activity by impairing its activation and the formation of lethal BAK oligomers. Parkin also suppresses BAX-mediated apoptosis, but in the absence of BAX ubiquitination suggesting an indirect mechanism. In addition, we find that BAK-dependent mitochondrial outer membrane permeabilisation during apoptosis promotes...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Autophagy & Cell Death, Post-translational Modifications, Proteolysis & Proteomics Articles Source Type: research
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Corrigendum Source Type: research
Introduction: In people with Parkinson's disease (PD) many aspects of walking ability deteriorate with advancing disease. Clinical tests typically evaluate single aspects of walking and to a lesser extent assess more complex walking tasks involving ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Falls Source Type: news
AbstractPurpose of ReviewIdiopathic REM sleep behavior disorder (iRBD) is one of the most significant prodromal manifestations of synucleinopathies. Different predictive biomarkers for iRBD conversion have been investigated, but scarce data are present in literature about the predictive role of cerebrospinal fluid (CSF) biomarkers. In this review, we focus on CSF biomarkers in patients with both iRBD and RBD associated with synucleinopathies to explore their potential predictive power.Recent FindingsRecent studies revealed that CSF α-synuclein levels are higher in Parkinson’s disease (PD) patients with RBD comp...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
α-Synuclein and Glia in Parkinson's Disease: A Beneficial or a Detrimental Duet for the Endo-Lysosomal System? Cell Mol Neurobiol. 2019 Jan 14;: Authors: Filippini A, Gennarelli M, Russo I Abstract Accumulation of α-synuclein (α-syn) species in dopaminergic neurons is one of the main hallmarks of Parkinson's disease (PD). Several factors have been associated with α-syn aggregation process, including an impairment of the proper protein degradation, which might drive the neurons toward an alternative and/or additional clearance mechanism that involves the release of undigested ma...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
Generic preference-based measures are used to assess the cost-utility of different interventions in Parkinson's disease (PD). However, the difficulty of using them in people with a particular health condition is that these measures may not encapsulate all of the domains that are impacted by the disease.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Oxidative stress plays a key role in Parkinson's disease (PD) etiopathology. Heme oxygenase, an important enzyme which regulates oxidative balance, converts heme molecules into carbon monoxide, iron and biliverdin/bilirubin. The role of bilirubin has not been fully studied in PD, showing controversial results over the last few decades. Our aim was to investigate the relationship between bilirubin levels and PD. Secondly, we sought to evaluate the link between bilirubin concentration with PD progression, severity and dopaminergic treatment.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
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