Construction and validation of clinical contents for development of learning objects.
CONCLUSION: The steps taken in the construction and validation of the content for the production of educational material for patients with head and neck cancer were adequate, relevant and suitable for use in other subjects. PMID: 29412287 [PubMed - in process]
This study highlighted the impact of each gum ingredient on the quality of the MCGs and demonstrated the feasibility of preparing chewing gums with up to 50% drug loading.Graphical abstract
Authors: Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O Abstract The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment. Given that cancer cells often show resistance to xCT inhibition resulting in glutathione (GSH) deficiency, however, we here performed a synthetic lethal screen of a drug library to identify agents that sensitize the GSH deficiency-resistant cancer cells to the xCT inhibitor sulfasalazine. This screen identified the oral anesthetic dyclon...
ConclusionHigher T stage and concurrent chemotherapy with radiotherapy showed significant association with chronic sinusitis. Concurrent chemotherapy also showed significant association with surgical treatment in head and neck cancer patients. Therefore, more careful surveillance and aggressive treatment of chronic sinusitis is needed in head and neck cancer patients who receive radiotherapy with concurrent chemotherapy or higher T stage.
AbstractLocally advanced oral cancers extending to infratemporal fossa (ITF) are a challenge to head and neck surgeons. These tumors are classified as T4b whenever the masticator space (MS), pterygoid muscles (PM), and pterygoid plates (PP) are involved according to AJCC classification. Until recently, these tumors were considered inoperable and treated only with palliative intent. However, a few studies in the last decade showed that many of these tumors could be resected with a reasonably favorable prognosis by compartment resection of ITF, particularly when the tumor was below sigmoid notch of mandible. A few studies at...
Condition: Head and Neck Cancer Intervention: Drug: Anti-EGFR monoclonal antibody Sponsors: Sinocelltech Ltd.; Cancer Institute and Hospital, Chinese Academy of Medical Sciences Not yet recruiting
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b14632
To date, no single molecular marker has been demonstrated as clinically useful in differentiating malignant from benign thyroid nodules when a fine needle aspiration falls in the “unknown significance” categor...
ConclusionsIn conclusion, we found that the homozygous mutant allele of rs10399805 and rs6691378 appeared to have significantly lower risk of lymph node metastasis and associated with its mRNA levels in oral cancer.Clinical relevanceThe CHI3L1 polymorphisms rs10399805 and rs6691378 may act as biomarkers for predicting lymph node metastasis in oral cancer patients.
Image-guided treatment has revolutionized the field of radiation oncology. Improved tumor visualization through CT and MRI in the 1970s prompted innovative methods of targeting: intensity modulated radiation therapy and multileaf collimators to deliver complex dose distributions (1). In head and neck cancer, for instance, these innovations are associated with improved survival and quality of life with reduced toxicities (2-4). Advances in functional and metabolic imaging create targets based on tumor biology (1).
(La Jolla Institute for Allergy and Immunology) Researchers at La Jolla Institute for Immunology (LJI) and UC San Diego have been awarded $ 4.5 million as part of the National Cancer Institute's Cancer Moonshot initiative. The funding will support research to develop new and improved immunotherapeutic treatment options for patients with head and neck cancer.