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Construction and validation of clinical contents for development of learning objects.

CONCLUSION: The steps taken in the construction and validation of the content for the production of educational material for patients with head and neck cancer were adequate, relevant and suitable for use in other subjects. PMID: 29412287 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research

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Publication date: Available online 23 February 2018 Source:Mutation Research/Reviews in Mutation Research Author(s): Alejandro D. Bolzán, Martha S. Bianchi Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including head and neck tumors, lymphomas, squamous-cell carcinomas and germ-cell tumors. Because of this, the study of BLM genotoxicity is of practical interest. This antibiotic is an S-independent clastogen and an agent that generates free radicals and i...
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research
Condition:   Head and Neck Neoplasms Intervention:   Other: Needs assesment tool integrated in nursing consultation. Sponsors:   Rigshospitalet, Denmark;   Novo Nordisk A/S;   Danish Nurses Organisation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionIt is feasible and safe to use this novel, flexible, single‐arm robot in performing a transoral robotic radical tonsillectomy and retropharyngeal lymph node dissection.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: OPERATIVE TECHNIQUES Source Type: research
Inhibition of NF-κB prevents the acidic bile-induced oncogenic mRNA phenotype, in human hypopharyngeal cells. Oncotarget. 2018 Jan 19;9(5):5876-5891 Authors: Vageli DP, Doukas SG, Sasaki CT Abstract Bile-containing gastro-duodenal reflux has been clinically considered an independent risk factor in hypopharyngeal carcinogenesis. We recently showed that the chronic effect of acidic bile, at pH 4.0, selectively induces NF-κB activation and accelerates the transcriptional levels of genes, linked to head and neck cancer, in normal hypopharyngeal epithelial cells. Here, we hypothesize that NF-&ka...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Ansari SS, Sharma AK, Zepp M, Ivanova E, Bergmann F, König R, Berger MR Abstract The TCGA database was analyzed to identify deregulation of cell cycle genes across 24 cancer types and ensuing effects on patient survival. Pan-cancer analysis showed that head and neck squamous cell carcinoma (HNSCC) ranks amongst the top four cancers showing deregulated cell cycle genes. Also, the median gene expression of all CDKs and cyclins in HNSCC patient samples was higher than that of the global gene expression. This was verified by IHC staining of CCND1 from HNSCC patients. When evaluating the quartiles with hig...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ConclusionInteractions with staff, patients and the hospital environment supported well‐being in those receiving cancer treatment. Findings demonstrate additional areas for research including the development of interventions to facilitate peer support and the implementation of communication strategies that promote well‐being.This article is protected by copyright. All rights reserved.
Source: Journal of Advanced Nursing - Category: Nursing Authors: Tags: Original Research: Empirical research ‐ qualitative Source Type: research
Abstract Radiotherapy is unlikely to benefit all patients with head and neck squamous cell carcinoma (HNSCC). Therefore, novel method is warranted to predict the radiotherapy response. Our study aimed to construct a microRNA (miRNA)‐based nomogram to predict clinical outcomes of patients with HNSCC receiving radiotherapy. We screened out 56 differential miRNAs by analyzing 44 paired tumor and adjacent normal samples miRNA expression profiles from The Cancer Genome Atlas (TCGA). A total of 307 patients with HNSCC receiving adjuvant radiotherapy were randomly divided into a training set (n = 154) and a validation...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
ConclusionAlthough not meeting the primary end point, results of multiple assessments suggest that D‐met decreased mucositis.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract ObjectivesPosttraumatic growth (PTG) is a possible positive consequence of a traumatic event, such as cancer. Head and neck cancer (HNC) may be particularly traumatic, given its adverse effects on functional, psychological and social wellbeing. We investigated: extent of PTG; factors associated with PTG; and associations between PTG and health‐related quality‐of‐life (HRQoL) in HNC survivors. MethodsHNC survivors (ICD10 C00‐C14, C32), identified from the population‐based National Cancer Registry Ireland, completed a postal survey. PTG was assessed using the Posttraumatic Growth Inventory (PTG‐I) and HR...
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research
CONCLUSIONS: HOTAIR rs4759314 may influence HNSCC susceptibility and serve as a diagnostic biomarker. PMID: 29461598 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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