Validation and reliability of the scale Self-efficacy and their child's level of asthma control.
Validation and reliability of the scale Self-efficacy and their child's level of asthma control. Rev Bras Enferm. 2018 Mar-Apr;71(2):406-412 Authors: Gomes ALA, Joventino ES, Lima KF, Dodt RCM, Almeida PC, Ximenes LB Abstract OBJECTIVE: To evaluate the psychometric properties in terms of validity and reliability of the scale Self-efficacy and their child's level of asthma control: Brazilian version. METHOD: Methodological study in which 216 parents/guardians of children with asthma participated. A construct validation (factor analysis and test of hypothesis by comparison of contrasted groups) and an analysis of reliability in terms of homogeneity (Cronbach's alpha) and stability (test-retest) were carried out. RESULTS: Exploratory factor analysis proved suitable for the Brazilian version of the scale (Kaiser-Meyer-Olkim index of 0.879 and Bartlett's sphericity with p
A MasterClass on New Avenues in Asthma Management: Finding the Right Patients for Targeted Therapies
Publication date: Available online 20 November 2018Source: Pharmacological ResearchAuthor(s): Antonietta Rossi, Fiorentina Roviezzo, Rosalinda Sorrentino, Maria A. Riemma, Ida Cerqua, Rossella Bilancia, Giuseppe Spaziano, Fabiana Troisi, Simona Pace, Aldo Pinto, Bruno D’Agostino, Oliver Werz, Giuseppe CirinoAbstractThe incidence and severity of asthma preponderate in women versus men. Leukotrienes (LTs) are lipid mediators involved in asthma pathogenesis, and sex disparities in LT biosynthesis and anti-LT pharmacology in inflammation have recently emerged. Here, we report on sex dimorphism in LT production during all...
Authors: Kobayashi T, Kanno K, Kikuchi Y, Kakimoto M, Kawahara A, Kimura K, Ishida R, Miyamori D, Otani Y, Kishikawa N, Tazuma S Abstract A 78-year-old woman with fever of unknown origin that had persisted for 3 months, systemic edema, and cervical lymphadenopathy was admitted to our hospital. Skin purpura and jaw claudication were subsequently observed. Histopathological examinations of the lymph nodes, skin, and temporal artery revealed findings characteristic of eosinophilic granulomatosis with polyangiitis (EGPA). However, she had no past medical history of asthma with modest eosinophilia. Although EGPA is a sy...
Conclusion: Overexpressed miR-485 inhibits cell proliferation and promotes apoptosis of ASMCs through the Smurf2-mediated TGF- β/Smads signaling pathway in mice with chronic asthma.Cell Physiol Biochem 2018;51:692 –710
CONCLUSION: GCE treatment increases MMP1 expression, leading to tight junction disruption, which is transcriptionally regulated and influenced by the ERK/MAPK pathway in airway epithelial cells. These findings may contribute to developing novel therapeutic strategies for airway diseases. PMID: 30450857 [PubMed - in process]
Abstract PURPOSE: Toluene diisocyanate (TDI) is a leading cause of occupational asthma (OA). Periostin is a matricellular protein implicated in type 2 immunity-driven asthma. Its pathogenic role in TDI-OA has not been completely elucidated. The present study was performed to investigate the role of periostin in TDI-OA. MATERIALS AND METHODS: Serum periostin levels were measured in subjects with TDI-OA, asymptomatic TDI-exposure controls (AECs), non-occupational asthmatics (NAs), and unexposed normal controls (NCs). To understand the mechanism by which TDI induces periostin production, primary small airway epi...
(US Army Medical Research Institute of Infectious Diseases) A global team of investigators has identified a key protein involved in Hantavirus Pulmonary Syndrome (HPS), a serious and sometimes fatal respiratory disease, according to research published today in Nature. The cell-surface receptor protein protocadherin-1 (PCDH1), commonly associated with human asthma, is responsible for facilitating lung cell infection and triggering HPS. Discovery of the cellular receptor for hantaviruses allows for rational and logical drug and antibody design to prevent the virus from infecting lung tissue.
CONCLUSIONS: Children aged 7-10 years can successfully perform FeNO measurements using a portable, electrochemical FeNO analyzer. Measurements from the 6 and 10-s exhalations were repeatable and consistent with a high degree of agreement between one another. Thus, in young children successful FeNO measurements can be obtained in either the 6-s or 10-s mode, providing physicians valuable information on airway inflammation to aid in the diagnosis and treatment of asthma. PMID: 30451052 [PubMed - as supplied by publisher]
ConclusionsThese findings suggest that questionnaire data cannot accurately substitute for assessment by experienced healthcare professionals using validated criteria for diagnosis of atopic dermatitis. Combining the parental report with diagnosis by a family physician might sometimes be appropriate (eg to avoid costs of a clinical assessment).