A Case of Squamous Cell Carcinoma of Unknown Primary that Responded to the Multi-Tyrosine Kinase Inhibitor Lenvatinib
Lenvatinib is an oral tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, fibroblast growth factor receptors 1 through 4, as well as platelet-derived growth factor receptor α, RET, and KIT. At present, lenvatinib is used in the treatment of thyroid cancer and renal cell carcinoma. We herein report a case of a 67-year-old patient with squamous cell carcinoma of unknown primary who was effectively treated with lenvatinib. The patient was initially diagnosed as having un differentiated thyroid cancer, and after total thyroidectomy and bilateral lymph node dissection, lenvatinib was administered for the treatment of residual lymph node metastasis. A computed tomography scan after 1 month of lenvatinib administration showed marked regression of the lymph nodes, but in terstitial pneumonia was also detected. Because the drug lymphocyte stimulation test for lenvatinib was strongly positive, we concluded that the interstitial pneumonia was induced by lenvatinib. The interstitial pneumonia only improved by the withdrawal of lenvatinib. Finally, his thyroid tumor was diagnosed as a metastasis of squamous cell carcinoma; however, we were unable to identify the primary lesion. This is the first reported case of interstitial pneumonia induced by lenvatinib.Case Rep Oncol 2018;11:75 –80
Antonio Macci ò, Silvia Busquets, Clelia Madeddu, Josep M. Argilés
Nikitas N. Nomikos, Pantelis T. Nikolaidis, Caio V. Sousa, Apostolos E. Papalois, Thomas Rosemann, Beat Knechtle
Publication date: Available online 17 December 2018Source: Redox BiologyAuthor(s): Jayshree Hirpara, Jie Qing Eu, Joanna Kia Min Tan, Andrea L. Wong, Marie-Veronique Clement, Kong Li Ren, Naoto Ohi, Takeshi Tsunoda, Jianhua Qu, Boon Cher Goh, Shazib PervaizAbstractThe ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime. Here we report evidence of enhanced reliance on mitochondrial oxidative phosphorylation (OXPHOS) in oncogene-ad...
Publication date: 1 March 2019Source: Carbohydrate Polymers, Volume 207Author(s): Rahul Bhatt, Padmaj PAbstractThiomers have recently attracted attention as effective adsorbents for Hg2+. In the present study a chitosan- thiobarbituric acid based thiomer(CTG) was investigated as a potential adsorbent for elemental mercury (Hg°), inorganic mercury (Hg2+) and methyl mercury (CH3Hg+). CTG was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), differential scanning calorimetry (DSC) and thermal gravimetric...
Dalton Trans., 2019, Advance Article DOI: 10.1039/C8DT03266A, PaperLeila Tabrizi, Lukman O. Olasunkanmi, Olatomide A. Fadare The cyclometalated ruthenium(II) complex was synthesized and studied for cytotoxicity. The interaction of Ru(II) complex with COX-2 was studied by experimental and molecular docking. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019,55,63-66 DOI: 10.1039/C8CC08866G, CommunicationYan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu, Fangrui Zhong Inspired by the heme iron-catalyzed radical insertion of dioxygen to the tryptophan indole ring, herein we utilize alkylperoxy radical species as a coupling partner to trigger a peroxycyclization of readily accessible tryptophan derivatives and enable the first synthesis of peroxypyrroloindolenines. The content of this RSS Feed (c) The Royal Society of Chemistry
Analyst, 2019, Advance Article DOI: 10.1039/C8AN02092B, PaperAritri Ghosh, Sreyan Raha, Susmita Dey, Kabita Chatterjee, Amit Roy Chowdhury, Ananya Barui FTIR spectroscopy and Raman spectroscopy of biological analytes are increasingly explored as screening tools for early detection of cancer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
India's federal drug regulator said on Tuesday a Reuters report that Johnson&Johnson knew for decades that cancer-causing asbestos lurked in its baby powder was "under consideration".
Abstract Free radicals are closely related to the occurrence and development of aging, cancer and inflammation. In this paper, the microbial transglutaminase (MTGase) was used as a catalyst to graft the collagen peptide (COP) molecules on the amino group of carboxymethyl chitosan sulfate (CMCS) to improve the antioxidant effects. FT-IR and NMR spectroscopy were used to confirm the successful grafting of COP to CMCS. Degree of substitution (DS) of CMCS-COP could be controlled by adjusting the reaction conditions. With the increase of concentration, the ability of each sample on scavenging capacity and reducibility ...
Viviana Anelli, Anita Ordas, Susanne Kneitz, Leonel Munoz Sagredo, Victor Gourain, Manfred Schartl, Annemarie H. Meijer, Marina Mione