Herbal Drug Kratom Contains Opioids, FDA Says
Title: Herbal Drug Kratom Contains Opioids, FDA SaysCategory: Health NewsCreated: 2/7/2018 12:00:00 AMLast Editorial Review: 2/8/2018 12:00:00 AM
Opioid therapy may not always be effective against chronic pain and could lead to depression, according to a National Institutes of Health Study.
The Cochrane Pain, Palliative and Supportive Care Group has been producing Cochrane Reviews for more than 20 years, including dozens covering a wide range of therapies for pain. In April 2018, their review of brain stimulation for chronic pain was updated and lead author Neil E O'Connell from Brunel University London in the UK tells us about the latest evidence in this podcast.
Authors: Cichowski SB, Rogers RG, Komesu Y, Murata E, Qualls C, Murata A, Murata G Abstract Introduction: Chronic pelvic pain (CPP) affects an estimated 30% of women Veterans. Previous research shows high rates of narcotic abuse in the women Veteran population. Narcotics are not recommended for the treatment of CPP. Understanding how CPP impacts narcotic prescribing in the women Veteran population is critical to addressing the public health crisis of opioid abuse. Our objective was to compare chronic opioid therapy (COT) prescribed 5 yr prior to and following CPP diagnosis and to identify predictors of COT as well ...
CONCLUSION: Although pain perception has multiple complex influences, the greatest variability seen in response to opioids among postoperative patients known to date can be traced to genetic differences in opioid metabolism. Further study is needed to determine the clinical significance of these genetic associations. PMID: 29791710 [PubMed - in process]
Conclusions Therefore, these inflammatory factors could be possible biological markers involved in this disease. Nevertheless, other studies are needed to consider this specific immune profile as a valid marker of the vulvodynia.
Researchers have shown that pain-induced changes in the rat brain ’s opioid receptor system may explain the limited effectiveness of opioid therapy in chronic pain and may play a role in the depression that often accompanies it. These findings clearly show the impact of chronic pain on the brain and its relation to depression.
Animal research suggests pain-induced changes in the brain ’s opioid receptor system may explain the limited effectiveness of opioid therapy in chronic pain; these changes also may play a role in the depression that often accompanies chronic pain.
Findings show the impact of chronic pain on the brain and its relation to depression.
Conditions: Low Back Pain; Pain Interventions: Drug: D-cycloserine; Drug: Placebo Sponsors: Northwestern University; United States Department of Defense Recruiting
Conclusion: With preoperative chemoradiotherapy, individualized APE may be a relatively safe and feasible approach for low rectal cancer with acceptable oncological outcomes. PMID: 29786037 [PubMed - in process]