A new target for the treatment of endometrium cancer by succinic acid.

A new target for the treatment of endometrium cancer by succinic acid. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):60-63 Authors: Iplik ES, Catmakas T, Cakmakoglu B Abstract Endometrium cancer is the most common invasive gynecologic malignancy in developed countries. Succinic acid (CO2HCH2-CH2CO2H) is a type of dibasic acid that has uncolored crystal. Succinic acid is used in bakery products and aromatized products. It is naturally found in some vegetables. Succinic acid has no adverse effects because it is metabolized by body cells and has a role in the tricarboxylic acid cycle (TCA) as a cycle media component. The TCA cycle and its enzyme components have some crucial roles for basal cell metabolism. Any mistakes, concentration differences in product, or enzyme deficiencies are important within the cell this cycle. In this proposal project, we aimed to investigate the effect of succinic acid at different doses and at different times in an endometrial cancer cell line. The study was performed using methods that determine for apoptosis (for cytotoxicity, WST-1, for caspase enzyme activity, Caspase 3/BCA; apoptotic determination using flow cytometry; Annexin V; to understand mitochondrial membrane potential; JC-1). The results showed that 5 and 10 µM concentration of succinic acid resulted in apoptosis in endometrium cancer; no such effect was seen in the control cell line, which comprised healthy lung cells.  According to our results, it i...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Related Links:

Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Alice H. Hsu, Michelle A. Lum, Kang-Sup Shim, Peter J. Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Yuri M. Sheinin, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. BlackSummaryProtein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling a shift in focus to understanding tumor suppressive functions of these enzyme...
Source: Cell Reports - Category: Cytology Source Type: research
CONCLUSION: Bariatric surgery is associated with decreased risk of hormone-related cancers, whereas gastric bypass might increase the risk of colorectal cancer. PMID: 30003539 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
ConclusionThe combination of hysteroscopic resection with LNG-IUD as fertility-sparing treatment of EEC and AEH showed similar response and live birth rates compared to those reported in literature for progestins alone, but a considerably lower relapse rate. We advocate the use of this combined approach as an alternative fertility-sparing option in patients with ECC and AEH.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionThe full extraperitoneal approach represents an interesting alternative strategy for the surgical treatment of obese patients with high-risk endometrial cancer.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Endometrial serous carcinoma (ESC) is a high-grade tumor of uterus and associated with unfavorable clinical outcome. Copy number variations (CNA) are frequently observed in this histological subtype. However the impact of recurrent CNA in these tumors was not systematically analyzed in ESC.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
ConclusionsAbout 1 of 4 patients (25%) with single gynecologic cancer recurrence needs IOUS to benefit from MIS for complete secondary cytoreduction.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
In this study, we aimed to estimate the frequency of premalignant and malignant lesions in endometrial polyps, and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of premalignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible. Independent investigators ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionConventional MRI findings in conjunction with DWI and, quantitative measurement of the ADC are effective methods in the, diagnosis and staging of uterine cancer.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
ConclusionHigh incidence of occult endometrial lesions in breast cancer patients in dependent of tamoxifen therapy, suggests pretreatment endometrial assessment.HSG is accurate in discrimination between focal and diffuse endometrial lesions, and help making a decision for either hysteroscopy or directed biopsy, but cannot reliably differentiate benign and malignant lesions.MRI DWI is accurate noninvasive method in distinguishing benign from malignant endometrial lesions which need further evaluation by biopsy.We recommend that HSG can be used as an initial investing technique in cases of endometrial abnormalities, however ...
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Liron Kogan, David Octeau, Zainab Amajoud, Jeremie Abitbol, Ido Laskov, Alex Ferenczy, Manuela Pelmus, Neta Eisenberg, Roy Kessous, Susie Lau, Amber Yasmeen, Walter H. Gotlieb, Shannon SalvadorAbstractObjectiveEvaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC).MethodsRetrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis we...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
More News: Biology | Cancer | Cancer & Oncology | Cancer of the Uterus | Endometrial Cancer | Molecular Biology | Study | Vegetables