Correlation between serum leptin and its gene expression to the anthropometric measures in overweight and obese children.

Correlation between serum leptin and its gene expression to the anthropometric measures in overweight and obese children. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):84-90 Authors: Eldosouky MK, Abdu Allah AM, AbdElmoneim A, Al-Ahmadi NS Abstract Obesity is a multifactor disorder with evidence supporting the role of the genetic factor in its etiology. The present study evaluates the relationship between leptin G2548A (rs7799039) and leptin receptors (Gln223Arg (rs1137101) genotyping and its leptin level and the risk of childhood obesity. This case-control study was conducted on 168 overweight and obese Saudi children and 126 non obese one served as control. Fasting insulin, leptin, blood glucose, lipid profile levels were measured. HOMA- IR, and BMI were assessed. Genotyping of leptin and leptin receptor gene variants was done by SNP real-time PCR method. GG genotype and G allele of rs1137101 were significantly higher in overweight and obese children than controls. It showed significant association with risk of obesity OR 7.1 [ 95% CI: 3.4 - 14.8] and OR 2.8 [ 95% CI: 2.0 - 4.1] respectively. Leptin level was significantly greater in patients than controls (p<0.000*) with GG and AG genotypes having the highest level of leptin when compared with another genotype in the obese group. As regards, rs7799039 AA genotype showed significant higher leptin level than other genotypes in the same group with a non-significant difference in genotypes distribut...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Psychiatric Care in Severe Obesity: An Interdisciplinary Guide to Integrated Care By Sanjeev Sockalingam, Raed Hawa, eds. Springer. 2017. £88.00 (hb). 357 pp. ISBN 9783319425344. Br J Psychiatry. 2018 Aug;213(2):503 Authors: Woodhouse J PMID: 30027873 [PubMed - in process]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Publication date: Available online 21 July 2018Source: Obesity Research &Clinical PracticeAuthor(s): George L. WehbyAbstractGenetic studies of BMI have largely focused on how average BMI changes with SNPs or polygenic risk scores (PRS). We examine the effects of a BMI PRS on changes in BMI percentiles, range, and skewness using quantile regression and US nationally representative data from the Health and Retirement Survey. We find that the BMI PRS is associated with meaningfully larger weight increases at higher than lower BMI percentiles; the 90th BMI percentile increases by 4.7 units with a one SD increase in the PRS...
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
This study enrolled 1875 subjects with normal glucose tolerance (age range: 20–78 years). VFA was assessed with magnetic resonance imaging.ResultsThe study population consisted of 1573 subjects without a FHD, 115 subjects with a paternal FHD, and 187 subjects with a maternal FHD. For both genders, VFA was greater in offspring with a maternal FHD compared with those without a FHD (both P 
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
In this study, we explore the effects of soluble epoxide hydrolase (sEH) deletion on various aspects of adipocyte-function, including programing for white vs. beige-like fat, and mitochondrial and thermogenic gene-expressions. We further hypothesize that EETs and heme-oxygenase 1 (HO-1) form a synergistic, functional module whose effects on adipocyte and vascular function is greater than the effects of sEH deletion alone. In in vitro studies, we examined the effect of sEH inhibitors on MSC-derived adipocytes. MSC-derived adipocytes exposed to AUDA, an inhibitor of sEH, exhibit an increased number of small and healthy adipo...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
ConclusionNAFLD is an additional risk factor in OSA subject which contributes to systemic inflammation in Asian Indians.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Publication date: Available online 21 July 2018Source: Journal of Molecular BiologyAuthor(s): Michela Miani, Bernat Elvira, Esteban N. GurzovAbstractDiabetes is a metabolic disorder affecting more than 400 million individuals and their families worldwide. The major forms of diabetes (type 1 and 2) are characterized by pancreatic β-cell dysfunction and, in some cases, loss of β-cell mass causing hyperglycemia due to absolute or relative insulin deficiency. The BCL-2 homology 3 (BH3)-only protein BIM has a wide role in apoptosis induction in cells. In this review, we describe the apoptotic mechanisms mediated by BI...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 21 July 2018Source: Journal of Science and Medicine in SportAuthor(s): Samantha M. McDonald, Jihong Liu, Sara Wilcox, Xuemei Sui, Russell R. PateAbstractObjectivesMaternal body mass index (BMI) is a significant determinant of infant macrosomia. Given the strong metabolic effects of physical activity (PA), independent of body mass, it is unclear as to whether maternal PA may affect the risk of delivering a macrosomic infant. Thus, the purpose of this study was to determine if maternal PA moderates the relationship between maternal BMI and infant macrosomia.DesignCross-sectional study using...
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Publication date: Available online 21 July 2018Source: Social Science &MedicineAuthor(s): Alexandra RodneyAbstractIn this paper, I investigate the contribution of healthy living blogs to discourse about healthy eating, seeking to understand how blogs compare to mass-media magazine sources. This is done by comparatively analysing 459 healthy living blog posts and 141 health and fitness magazine articles. These were collected between 2011 and 2013 and provide rich data about what food content looks like in media designed for an audience of American women. I analyze how each source establishes the purpose of healthy eatin...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 21 July 2018Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): X. Liu, D. Zhang, Y. Liu, X. Sun, Y. Hou, B. Wang, Y. Ren, Y. Zhao, C. Han, C. Cheng, F. Liu, Y. Shi, X. Chen, L. Liu, G. Chen, S. Hong, M. Zhang, D. HuAbstractBackground and aimMany studies have shown increased risk of stroke with greater adiposity as measured by body mass index (BMI), but questions remain about the shape of the dose–response relation. We conducted a systematic review and meta-analysis of prospective studies to clarify the strength and shape of the dose–response relation between B...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Abstract AIMS: The sodium-glucose cotransporter (SGLT) 2 inhibitor, ipragliflozin, improves not only hyperglycemia but also obesity in type 2 diabetic animals and patients; however, there have been concerns that it may also cause an increase in compensatory food intake. Appetite is regulated by complex mechanisms involving the central nervous system, part of which involves appetite-related hormones and arteriovenous differences in postprandial glucose levels. We evaluated the effect of ipragliflozin in type 2 diabetic rats on food intake, appetite-related hormones and arteriovenous differences in postprandial gluc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
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