Differentially expressed Secretoglobin 1C1 gene in nasal polyposis.

In this study, to determine the relationship between the Secretoglobin 1C1 gene promotor polymorphisms and the gene expression, the levels of 48 subjects were sequenced (24 patients with NP and 22 controls without sinonasal disease). The levels' expression of Secretoglobin 1C1 in the subjects' nasal mucosa was also detected using RT-PCR.  In this study, the level of Secretoglobin 1C1's expression increased in NP (P= 0.003). Three polymorphisms were detected in the Secretoglobin 1C1 gene's promotor. The rs113795008 and rs2280540 variations were significantly high in NP (P= 0.005, P= 0.045). The the rs113795008 homozygous mutant type genotype (G/G) was associated with a high mRNA expression level of Secretoglobin 1C1 in NP (P= 0.009). A correlation was found between a high level of Secretoglobin 1C1 expression and its promotor polymorphism, which thus might increase and/or contribute to the susceptibility of developing NP in the Turkish population. These findings suggested that promotor variations in the function of the Secretoglobin 1C1 gene can alter the gene expression biology in NP. PMID: 29412801 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Conclusions: This pilot study demonstrated that quantification of plasma exosomes is a potential alternative screening method for detecting individuals with a high risk of colorectal malignancy.Digestion 2018;98:270 –274
Source: Digestion - Category: Gastroenterology Source Type: research
Contributors : Yuki Morimoto ; Kiyoshi Hirahara ; Masahiro Kiuchi ; Tomoko Wada ; Tomomi Ichikawa ; Toshio Kanno ; Mikiko Okano ; Kota Kokubo ; Atsushi Onodera ; Daijyu Sakurai ; Yoshitaka Okamoto ; Toshinori NakayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMemory helper T cells provide long-lasting host defeMemory helper T cells provide long-lasting host defense against microbial pathogens, while distinct subpopulations of memory T cells drive chronic inflammatory diseases such as asthma. Asthma is a chronic allergic inflammatory disease with airway remodeling including fibrot...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
ConclusionEvaluation of cases of perimenopausal and postmenopausal bleeding differentiated premalignant and malignant lesions of the uterine body, endometrium and cervix. As our centre is a Regional Cancer Centre of Bihar, incidence of malignant lesions is higher in our centre.
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
DiscussionThe present prospective study shows that the surgeon should be able to select those gallbladders needing a microscopic gallbladder examination. Potentially, about 80% of this kind of routine histology can be reduced.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Condition:   Screening Colonoscopy Intervention:   Device: Computer Algorithm Sponsor:   New York University School of Medicine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
AbstractColorectal cancer (CRC) placed among the most common neoplasm. Survivin is a member of the inhibitor apoptosis gene family. This gene could be associated with aggressive behavior in numerous types of cancers. The aim of the present study was to evaluate the immunohistochemical expression of survivin gene and its correlation with −31G/C polymorphism in CRC patients. This case–control study was performed on 90 cases: 30 adenocarcinoma, 30 adenomatous polyp, and 30 normal colon. Immunohistochemical expression of survivin evaluated on formalin-fixed paraffin-embedded tissue and −31G/C polymorphism was...
Source: Medical Molecular Morphology - Category: Molecular Biology Source Type: research
Conclusion: The 30 seconds additional observation with LCI improved the detection of adenoma and SSA/P in the right-sided colon. PMID: 30116263 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Abstract For decades, colorectal screening strategies have been largely driven by static features, particularly polyp size. Although cross-sectional features of polyp size, morphology, and location are important determinants of clinical relevance before histology, they lack any dynamic information on polyp growth rates. Computed tomography colonography allows for in vivo surveillance of colorectal polyps, providing volumetric growth rates that are providing new insights into tumorigenesis. In this article, existing cross-sectional and longitudinal data on colorectal polyps are reviewed, with an emphasis on ho...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Gastroenterol Clin North Am Source Type: research
Publication date: Available online 18 August 2018Source: Journal of Molecular BiologyAuthor(s): Nicholas Yoo, Siddhant Dogra, Ben A. Meinen, Eric Tse, Janine Haefliger, Daniel R. Southworth, Michael J. Gray, Jan-Ulrik Dahl, Ursula JakobAbstractInorganic polyphosphate (polyP) constitutes one of the most conserved and ubiquitous molecules in biology. Recent work in bacteria demonstrated that polyP increases oxidative stress resistance by preventing stress-induced protein aggregation, and promotes biofilm formation by stimulating functional amyloid formation. To gain insights into these two seemingly contradictory functions o...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
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