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High temperature requirement factor A1 (HTRA1) regulates the activation of latent TGF- β1 in keloid fibroblasts.

High temperature requirement factor A1 (HTRA1) regulates the activation of latent TGF-β1 in keloid fibroblasts. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):107-110 Authors: Jin SF, Wang YX, Xu N, Sun Q, Wang CC, Lv MZ, Sun X, Guo S Abstract Scar treatments are considered a major issue in the plastic surgery field. Activation of the transforming growth factor-β (TGF-β)-mediated signaling pathway plays a key role in the scar pathogeneses, and high temperature requirement factor A1 (HTRA1) inhibits TGF-β1 activation in tumor cells. Our study aims to investigate the role of HTRA1 in the pathogenesis of scars. The mRNA levels of HTRA1 was evaluated by real time PCR, HTRA1 protein expression was determined using western blot and immunohistochemistry, and a luciferase assay was applied to measure dynamic changes of TGF-β1 activity. We found that the expression of HTRA1 was significantly elevated in keloid tissues, compared to normal skin, and TGF-β1 mRNA levels slightly increase in the keloid tissue. Furthermore, active TGF-β1 protein levels and Smad2 phosphorylation significantly increased in the keloid tissue. Treatment with the latent TGF-β1 or recombinant human HTRA1 (rhHTRA1), alone or in combination, increased Smad2 phosphorylation levels in keloid fibroblasts and active TGF-β1 contents of associated supernatants. Our results suggest that HTRA1 is involved in the pathogenesis of scars through regulating ac...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derive...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
AbstractKeloid, a benign skin disorder, forms during wound healing in genetically susceptible individuals. To better control keloid and understand the molecular mechanisms, this study screened gene hypermethylations of GEO database microarray data on keloids and identified the hypermethylation of the secreted frizzled related protein-1 (SFRP1) promoter. Subsequently, hypermethylation and mRNA and protein levels were assessed in 57 cases of keloid vs. normal skin tissues. Fibroblasts from tissues were isolated for the assessment of gene regulation in vitro. The methods used were bioinformatic analysis, lentiviral infection ...
Source: Journal of Molecular Histology - Category: Laboratory Medicine Source Type: research
Martha Roberts, ACNP, PNP, and James R. Roberts, MD, tackle another weird and wild case. This month, they treat a patient with a keloid that was causing pain. Check out their video, and read more in their blog at http://bit.ly/ProceduralPause.
Source: Emergency Medicine News - Video - Category: Databases & Libraries Source Type: video
Conditions:   Skin Diseases;   Keloid;   Scar;   Fibrosis;   Hypertrophic Skin Interventions:   Device: HF-LED-RL Phototherapy;   Device: Mock Therapy Sponsors:   VA Northern California Health Care System;   East Bay Institute for Research and Education Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Our study demonstrates that numerous lncRNAs are involved in the pathogenesis and development of the keloid. PMID: 29422825 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Facial plast Surg 2018; 34: 075-081 DOI: 10.1055/s-0037-1617446Isotretinoin is a first generation retinoid with pleiotropic effects on keratinocyte differentiation, proliferation, and activity of sebaceous glands. For years, there has been intense debate on whether the use of isotretinoin combined with cosmetic or surgical procedures is safe and potentially more efficient than either therapy alone. Due to delays in wound healing and keloid formation, conservative recommendations were not to combine isotretinoin with any plastic surgery or local treatment at 6 to 12 months after discontinuation of the drug. However, there i...
Source: Facial Plastic Surgery - Category: Cosmetic Surgery Authors: Tags: Original Article Source Type: research
Keloids are a burden for patients due to physical, aesthetic and social consequences. Treatment remains a challenge due to therapy resistance and high recurrence rates. The main goals of treatment are to improve scar appearance and symptoms and patients' quality of life (QoL).
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
CONCLUSION Overall, BoNT-A has the potential to prevent or treat pathologic scars in patients with a known personal or family history of keloids and hypertrophic scars, which may improve patient psychosocial distress and reduce clinic visits and health care costs. Variability in keloid and hypertrophic scar response to BoNT-A may be due to interexperiment differences in dosing, tissue donors, and assay sensitivity.
Source: Dermatologic Surgery - Category: Dermatology Tags: Review Article Source Type: research
No abstract available
Source: Dermatologic Surgery - Category: Dermatology Tags: Commentary Source Type: research
Hypertrophic scars (HTS) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ECM) deposition. Current therapies still fall short and cause undesired effects. We aimed to thoroughly evaluate the ability of growth hormone releasing peptide 6 (GHRP6) to both prevent and reverse cutaneous fibrosis and to acquire the earliest proteome data supporting GHRP6’s acute impact on aesthetic wound healing. Two independent sets of experiments addressing prevention and reversion effects were conducted on the classic HTS model in rabbits. In the prevention approach, the wounds were assigned to to...
Source: International Wound Journal - Category: Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
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