Testosterone to estrogen conversion is not responsible for the vasodilating effects of testosterone ex vivo.

Testosterone to estrogen conversion is not responsible for the vasodilating effects of testosterone ex vivo. Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):111-117 Authors: Tan S, Yi D, Zhu W, Sun R, Wei M Abstract Men have a higher incidence of cardiovascular disease, but poorer vasodilatation than women. However, testosterone exerts vasodilating actions ex vivo. We aimed to determine if reactive oxygen species (ROS) produced in vivo could cause 'eNOS uncoupling' that accounts for the disparity between in vivo and ex vivo results. Ovariectomized SHR and WKY rats were divided into 3 groups: untreated, estradiol benzoate (EB) treated, and testosterone propionate (TP) treated. EB and TP rats were treated for 8 weeks, and blood pressure, serum estrogen, progesterone, and testosterone were measured. Rats were euthanized and aorta samples were taken for examination of nitric oxide, phosphorylated eNOS (p-eNOS), H2O2, gr91phos, and pAkt. Mesenteric arterial rings were used in myographic studies of endothelium dependent and independent vasorelaxation. The influence of testosterone added to the bathing solution of rings from testosterone-supplemented rats with/without an eNOS inhibitor, with/without blockade of androgen or estrogen receptors, and with/without an inhibitor of gp91phox was examined. Treatment with testosterone for 8 weeks did not change endothelium-dependent relaxation in response to acetylcholine in the presence or absence of the eNOS inhibitor...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Authors: Mendoza De La Garza M, Tieu C, Schroeder D, Lowe K, Tung E Abstract Medical schools throughout the country struggle with how best to train students to provide quality, patient-centered care to the burgeoning population of older adults. The Senior Sages Program (SSP) is a longitudinal Senior Mentor Program (SMP) that offers students the opportunity to learn about the aging process and core geriatric medicine concepts through the eyes of an aging expert: their Senior Sage. The SSP marries a robust electronic curriculum with an SMP and online discussion board. The aim of this program evaluation was to measure...
Source: Gerontology and Geriatrics Education - Category: Geriatrics Tags: Gerontol Geriatr Educ Source Type: research
A single hailstorm changed me from rational to irrational... The post How to Use Framing to Sell More Warranties and Service Contracts appeared first on Neuromarketing.
Source: Neuromarketing - Category: Neuroscience Authors: Tags: Neuromarketing Source Type: blogs
Discussion When men enacted female-typical caregiving roles, their retirement timing resembled women's. Eldercare, in particular, was associated with earlier retirement timing. Implications for individual retirement decision-making and policy are discussed. PMID: 29911387 [PubMed - as supplied by publisher]
Source: International Journal of Aging and Human Development - Category: Geriatrics Tags: Int J Aging Hum Dev Source Type: research
The former Tory leader has urged his party to consider legalising recreational use of the drug.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
According to Toronto-based scholar Dr  Jeanette Bicknell from York University, people's feelings about their use of time contributes to wellbeing as much as their wealth.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
STOMACH bloating is caused by eating something that your stomach disagrees with, or something that you're allergic to. It involves a swelling in the stomach which can be painful. Juicing guru, Jason Vale, recommended trying this drink on ITV's This Morning to help beat the bloat.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
LONDON (Reuters) - Britain said on Tuesday it had no intention of legalizing cannabis after a former leader of Prime Minister Theresa May's party said the government had "irreversibly lost" the battle to drive the drug off the streets.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Researchers from  the Centers for Disease Control and Prevention in Atlanta, Georgia, found HIV tests can give false negative results for up to seven months among those taking PrEP.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSION: Childhood cholesteatoma was more extensive and destructive compared to adults, representing a more aggressive disease in this cohort. PMID: 29909808 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
CONCLUSION: The results show a good correlation between the pre-operatively predicted insertion depths using the software application and those post-operatively measured using X-ray. The insertion length predicted by the software was always longer than that measured via X-ray. PMID: 29909807 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
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