Ethanol promotes apoptosis in rat ovarian granulosa cells via the Bcl-2 family dependent intrinsic apoptotic pathway.

This study recruited rat ovarian granulosa cells, the primary effector of ovary, to investigate the effects of ethanol on cell apoptosis and explore potential mechanism. Ovarian granulosa cells treated with ethanol for three hours manifested observable reduction in cell viability and apparent apoptosis. In the presence of 200 and 300 mmol/l of ethanol, the percentages of apoptotic cells increased to 33% and 36%, respectively. In addition, apoptosis related caspase-3 activity was elevated with increasing concentrations of ethanol, suggesting a dose dependent effect. Furthermore, high concentrations of ethanol significantly disturbed the transcriptional and translational regulation of anti-apoptotic Bcl-2 and pro-apoptotic Bax, which are the two key members of Bcl-2 family tightly involved in intrinsic apoptotic pathway. These results indicated that ethanol promotes apoptosis in rat ovarian granulosa cells, possibly via the intrinsic apoptotic pathway. PMID: 29412806 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Publication date: 15 September 2018 Source:Catalysis Today, Volume 314 Author(s): Chuleehat Sriakkarin, Wasakon Umchoo, Waleeporn Donphai, Yingyot Poo-arporn, Metta Chareonpanich In this work, with an attempt to improve both economic and ecological aspects towards green production of methanol, an external magnetic field was equipped with a catalytic packed-bed reactor for selective production of methanol through CO2 hydrogenation over Cu and Fe loaded on microporous ZSM-5 zeolite. The effects of reaction temperatures (180–260 °C) and CO2/H2 molar ratios (1:1–1:4) on selective methanol production were inv...
Source: Catalysis Today - Category: Chemistry Source Type: research
Green Chem., 2018, Accepted Manuscript DOI: 10.1039/C8GC01366G, CommunicationChristopher S Lancefield, Lucas Teunissen, Bert Weckhuysen, Pieter C A Bruijnincx Lignin is a potentially abundant renewable resource for the production of aromatic chemicals, however its selective depolymerisation is challenging. Here, we report a new catalytic system for the depolymerisation of... The content of this RSS Feed (c) The Royal Society of Chemistry
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As the opioid crisis continues, an estimated one baby is born every 20 minutes to a mother who is addicted to the painkilling drugs. But doctors have few proven ways to treat those infants who become dependent on opioids in utero and are born in withdrawal from the drugs. “Despite the fact that we have seen increases in NAS in recent years, there is still significant uncertainty about who to treat, when to treat and what agents to use,” says Dr. Jonathan Davis, vice chair of pediatrics at Tufts Medical Center. “And then there are questions about how fast to increase the dose, and how fast to take the babi...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime medicine onetime Source Type: news
As the debate over beneficial or detrimental effects of alcohol on Alzheimer's disease continues, researchers examine the cellular and genetic mechanisms that may explain its impact on amyloid plaque in the brain.Medscape Medical News
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Buried in a new N.I.H. report are disturbing examples of coordination between scientists and the alcohol industry on a study that could have changed America ’ s drinking habits.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alcoholic Beverages Clinical Trials Alcohol Abuse Breast Cancer Heart Liquor National Institutes of Health Collins, Francis S Source Type: news
July 10, 2018 1:00-2:00pm ET.
Source: HSR Information Central - Category: International Medicine & Public Health Source Type: news
While most parents said they would report a ride operator who appeared impaired by alcohol or drugs, less than half said they would report a ride operator who used a cellphone while operating a ride.
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Authors: Ali B, Nisar N, Nawab F Abstract Background: Human immunodeficiency virus (HIV) is fifth leading cause of mortality and disability among infectious diseases worldwide. HIV burden is increasing annually and compliance with antiretroviral therapy (ART) is low among intravenous drug users, especially in developing countries. Aim: To determine the adherence level to ART among HIV-positive intravenous drug users in Karachi Pakistan. Methods: A cross-sectional study was conducted in 2015. A pretested questionnaire was administered to 375 of 3000 people who inject drugs, registered at the Civil Hospital i...
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
While most parents said they would report a ride operator who appeared impaired by alcohol or drugs, less than half said they would report a ride operator who used a cellphone while operating a ride.
Source: WebMD Health - Category: Consumer Health News Source Type: news
I have been informed by the USC Suzanne Dworak-Peck School of Social Work that the School and its research team that had been involved in the Smart Drinking Goals project terminated its involvement with the project in April 2018 and that they are no longer associated in any way with the project.The USC team had prepared toolkits summarizing the best current scientific thinking regarding environmental strategies for alcohol prevention. Although the team's involvement was apparently slated to last at least through 2018, they terminated their involvement in April and have completely disassociated themselves from the Smart Dri...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
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