Ethanol promotes apoptosis in rat ovarian granulosa cells via the Bcl-2 family dependent intrinsic apoptotic pathway.

This study recruited rat ovarian granulosa cells, the primary effector of ovary, to investigate the effects of ethanol on cell apoptosis and explore potential mechanism. Ovarian granulosa cells treated with ethanol for three hours manifested observable reduction in cell viability and apparent apoptosis. In the presence of 200 and 300 mmol/l of ethanol, the percentages of apoptotic cells increased to 33% and 36%, respectively. In addition, apoptosis related caspase-3 activity was elevated with increasing concentrations of ethanol, suggesting a dose dependent effect. Furthermore, high concentrations of ethanol significantly disturbed the transcriptional and translational regulation of anti-apoptotic Bcl-2 and pro-apoptotic Bax, which are the two key members of Bcl-2 family tightly involved in intrinsic apoptotic pathway. These results indicated that ethanol promotes apoptosis in rat ovarian granulosa cells, possibly via the intrinsic apoptotic pathway. PMID: 29412806 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Publication date: Available online 15 December 2018Source: Journal of Organometallic ChemistryAuthor(s): Qian Hu, Suyun Jie, Pierre Braunstein, Bo-Geng LiAbstractTridentate 2,6-bis(imino)phenol (L1−L4) and 2,6-bis(amino)phenol (L5−L7) ligands and their corresponding zinc chloride complexes (1–7) have been synthesized and well characterized by FT-IR, 1H and 13C NMR, elemental analysis and single-crystal X-ray diffraction analysis. It was found that zinc complexes (1–4) with 2,6-bis(imino)phenol ligands were inactive for the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) ev...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
CONCLUSIONS: Alcohol consumption patterns varied widely across settings and binge drinking was more frequent in HIV-positive individuals compared to the general population. Interventions to reduce excessive alcohol use are urgently needed to optimize adherence in the era of universal ART. PMID: 30549445 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Recent surveys have found a strong decrease in alcohol consumption among young people and this trend has been identified in European countries, Australia and North America. Previous research suggests that the decline in alcohol consumption may be explained...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Publication date: Available online 16 December 2018Source: Journal of Advanced ResearchAuthor(s): Nasser A.M. Barakat, Mohamed T. Amen, Fahad S Al-Mubaddel, Mohammad Rezual Karim, Maher AlrashedAbstractSynthesis of NiSn alloy nanoparticle-incorporated carbon nanofibers was performed by calcining electrospun mats composed of nickel acetate, tin chloride and poly(vinyl alcohol) under vacuum. The electrochemical measurements indicated that utilization of tin as a co-catalyst could strongly enhance the electrocatalytic activity if its content and calcination temperature were optimized. Typically, the nanofibers prepared from c...
Source: Journal of Advanced Research - Category: Research Source Type: research
Conclusion: Biliary reflux and alcohol consumption, but not Helicobacter pylori infection or gastrotoxic drug, seem to be the most important predictors for ulcer recurrence in patients with gastric surgery for peptic ulcer after more than 15 years. PMID: 30524477 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
BACKGROUND: In a year when UK drug-related deaths and festival drug-related deaths reached their highest on record, a pilot festival drug safety testing service was introduced with the aim of reducing drug-related harm. This paper describes the operational...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
This report identifies the specific drugs involved most frequently in drug overdose deaths in the United States from 2011 through 2016. Methods--Record-level data from the 2011-2016 National Vital Statistics System-Mortality files were linke...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
BACKGROUND: The entertainment precincts of cities, while contributing to local economies, need to be carefully managed to mitigate harms. Individual behaviours and government regulation have typically been the foci of interventions aimed at reducing alcoho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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