Ethanol promotes apoptosis in rat ovarian granulosa cells via the Bcl-2 family dependent intrinsic apoptotic pathway.

This study recruited rat ovarian granulosa cells, the primary effector of ovary, to investigate the effects of ethanol on cell apoptosis and explore potential mechanism. Ovarian granulosa cells treated with ethanol for three hours manifested observable reduction in cell viability and apparent apoptosis. In the presence of 200 and 300 mmol/l of ethanol, the percentages of apoptotic cells increased to 33% and 36%, respectively. In addition, apoptosis related caspase-3 activity was elevated with increasing concentrations of ethanol, suggesting a dose dependent effect. Furthermore, high concentrations of ethanol significantly disturbed the transcriptional and translational regulation of anti-apoptotic Bcl-2 and pro-apoptotic Bax, which are the two key members of Bcl-2 family tightly involved in intrinsic apoptotic pathway. These results indicated that ethanol promotes apoptosis in rat ovarian granulosa cells, possibly via the intrinsic apoptotic pathway. PMID: 29412806 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Young Americans are dying in rising numbers because of drugs, alcohol and suicide, according to new federal data. The Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS) issued its annual comprehensive health and mortality report, which analyzes trends in death rates by cause and demographic. Drugs, alcohol and suicide, the report says, have contributed to the first drops in U.S. life expectancy since 1993. While U.S. life expectancy rose from 77.8 to 78.6 years between 2006 and 2016, the trend reversed during the end of the decade, leading to a 0.3-year decline between 2014 and ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
Young Americans are dying in rising numbers because of drugs, alcohol and suicide, according to new federal data. The Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS) issued its annual comprehensive health and mortality report, which analyzes trends in death rates by cause and demographic. Drugs, alcohol and suicide, the report says, have contributed to the first drops in U.S. life expectancy since 1993. While U.S. life expectancy rose from 77.8 to 78.6 years between 2006 and 2016, the trend reversed during the end of the decade, leading to a 0.3-year decline between 2014 and ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
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Publication date: October 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 10Author(s): Yi-Wen Huang
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