Association between Vitamin D level and/or deficiency, and systemic lupus erythematosus: a meta-analysis.

This study aimed to evaluate the relationship between the level of 25-hydroxyvitamin D [25(OH)D] and systemic lupus erythematosus (SLE). We searched the PUBMED, EMBASE, and Cochrane databases and performed a meta-analysis examining the vitamin D level and/or deficiency in patients with SLE, compared with that in healthy controls. In total, 18 studies consisting of 1,083 patients with SLE and 1,273 controls were included. Vitamin D level was significantly lower in the SLE group than in the control group (standardized mean difference [SMD] = -0.938, 95% CI = -1.352 to -0.524, p = 9.0 × 10-6). Stratification by ethnicity showed a significantly decreased vitamin D level in the SLE group in the European and Arab populations (SMD = -1.485, 95% CI = -2.427 to -0.543, p = 0.002; SMD = -1.067, 95% CI = -1.251 to -0.883, p < 1.0 × 10-8), and an association tendency between decreased vitamin D level and SLE in the Asian population (SMD = -0.874, 95% CI = -2.073 to -0.324, p = 0.153). Subgroup analysis by sample size showed a significantly lower vitamin D level in the SLE group in small- (n ≤ 100) and large-sample (n > 100) populations (SMD = -1.008, 95% CI = -1.672 to -0.344, p = 0.003; SMD = -0.863, 95% CI = -1.444 to -0.293, p = 0.003). Meta-analysis revealed a significant association between SLE and vitamin D deficiency (RR = 2.321, 95% CI = 1.361-3.960, p = 0.002). Stratification by ethnicity showed a significant association between SLE and vitamin D deficiency ...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Lara-Cisneros L, Santa Cruz FJ, Cervera R Abstract The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetric complications in patients with antiphospholipid antibodies. Current data show that patients with antiphospholipid syndrome have a high prevalence of vitamin D deficiency even without classic risk factors. Several studies have suggested vitamin D ma...
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
by Hoda A. Hussein, MD; Lamiaa I. Daker, MD; Nermeen A. Fouad, MD; Azza Elamir, MD; and Shereen R. Mohamed, MD Dr. Hussein is with the Internal Medicine Department, Dr. Daker is with the Neurology Department, Dr. Fouad is with the Rheumatology Department, and Drs. Elamir and Mohamed are with the Medical Biochemistry Department—all with […] The post Does Vitamin D Deficiency Contribute to Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus? appeared first on Innovations in Clinical Neuroscience.
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Cognition Current Issue Original Research cognitive impairment neuropsychiatric systemic lupus erythematosus Vitamin D Source Type: research
AbstractThe aim of this study is to evaluate the relationship between baseline serum 25-hydroxyvitamin D3 levels and SLE activity/flares over time. This is a longitudinal study of 276 patients who fulfilled ≥ 4 ACR criteria for SLE and recruited in the year 2011. Serum samples were collected at baseline and assayed for 25-hydroxyvitamin D3 at the end of a mean follow-up of 32.5 months. Participants were stratified into three groups according to baseline 25-hydroxyvitamin D3 levels: group I (  30 ng/ml, adequate). Baseline and summated SLE disease activity index (SLEDAI) score over time and the an...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
CONCLUSIONS: Vitamin D deficiency may contribute to the development of a non-dipper pattern in patients with SLE. PMID: 30183606 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Conclusion: VitD serum values were lower in lupus patients than RA ones. Since VitD deficiency is very common in Iran, physiologic doses of VitD supplementation in patients lead to higher serum levels of VitD. Lower VitD values in lupus patients compared with RA ones may stem from intestinal malabsorption, higher doses of corticosteroid therapy, renal involvement and proteinuria, different polymorphisms of VitD receptors, and more sun protection strategies in lupus patients. PMID: 29854015 [PubMed]
Source: Open Rheumatology Journal - Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Conclusion Serum vitamin D levels are inversely correlated with SLE disease activity at both active and inactive disease status, and also with the presence of LN at active disease stage.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
ConclusionThis study suggests that cholecalciferol supplementation for 24  weeks effectively improved the bone microarchitecture parameters, mainly the trabecular number, in JoSLE patients.Trial RegistrationNCT01892748
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Publication date: Available online 31 January 2018 Source:Autoimmunity Reviews Author(s): Stefano Stagi, Donato Rigante Systemic lupus erythematosus (SLE) and juvenile SLE (jSLE) are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors. It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active part in many comorbidities and even complications. A host of clinical studies suggested that vitamin D exerts inhibitory effects on many immunological abnormalities associated with SLE, also...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
In conclusion, no factor of the epidemiologic triad was associated with HPV infection prevalence. PMID: 29732937 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
AbstractVitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population. Although evidences showed the connotation between systemic lupus erythematosus (SLE) and vitamin D through which SLE can lead to lower vitamin D levels, it is also important to consider the possibility that vitamin D deficiency may have a causative ro...
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research
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