Circulating prolactin levels and Behcet's disease: A meta-analysis.
This study aimed to summarize the current evidence on the relationship between circulating prolactin levels and Behcet's disease (BD). We performed a meta-analysis comparing the serum/plasma prolactin levels in patients with BD with those of controls and performed a subgroup analysis based on ethnicity, disease activity, and sex. Ten articles with a total of 320 patients with BD and 259 controls were included. The prolactin levels were not significantly higher in the BD group than in the control group (SMD=0.208, 95% CI=-0.012-0.428, p=0.064). Stratification by ethnicity indicated no elevation in prolactin level in Turkish patients with BD (SMD=0.127, 95% CI=-0.111-0.366, p=0.295). Stratification by disease activity revealed no elevation in prolactin level in both the active and inactive BD groups compared with the control group (SMD=0.373, 95% CI=-0.095-0.841, p=0.119; SMD=0.055, 95% CI=-0.243-0.354, p=0.717). Stratification by sex revealed no elevation in prolactin level in both the female and male BD groups (SMD=0.031, 95% CI=-0.398-0.460, p=0.888; SMD=0.279, 95% CI=-1.411-1.969, p=0.746). The prolactin levels were not significantly elevated in patients with BD, regardless of the adjustments for age/sex, sample size, or data type evaluated. This meta-analysis of current evidence suggests that circulating prolactin levels may not be higher in patients with BD than in controls. PMID: 29412808 [PubMed - in process]
Conditions: Behcet's Disease; Central Sensitisation Interventions: Diagnostic Test: Central sensitisation; Diagnostic Test: Neuropathic pain; Other: Sleep disturbance; Other: Quality of life Sponsor: Bursa Yüksek İhtisas Education and Research Hospital Not yet recruiting
Conclusion There are significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia in BD patients. The normocytic anemia is the most common type of anemia in our 63 BD patients. We suggest that supplementations of vitamin BC capsules plus deficient vitamin B12 and/or folic acid may reduce the abnormally high serum homocysteine level to a relatively lower level in BD patients with hyperhomocysteinemia.
Conclusion Serum endocan may serve as a potential marker of disease activity in BD. Patients with genital ulcers, papulopastular lesions and arthritis showed higher serum endocan levels.
Compression of the celiac artery by the median arcuate ligament (MAL) and neurofibrous tissue is called MAL syndrome or Dunbar ’s syndrome. Postprandial abdominal pain, weight loss are the main symptoms. Surgical treatment still remains the gold standard therapy. Here, we present the first case to our knowledge that accompanying Behcet's disease to Median Arcuate Ligament Syndrome.
Condition: Behcet's Disease Intervention: Drug: GSK1070806 Sponsor: Cambridge University Hospitals NHS Foundation Trust Not yet recruiting