Circulating prolactin levels and Behcet's disease: A meta-analysis.
This study aimed to summarize the current evidence on the relationship between circulating prolactin levels and Behcet's disease (BD). We performed a meta-analysis comparing the serum/plasma prolactin levels in patients with BD with those of controls and performed a subgroup analysis based on ethnicity, disease activity, and sex. Ten articles with a total of 320 patients with BD and 259 controls were included. The prolactin levels were not significantly higher in the BD group than in the control group (SMD=0.208, 95% CI=-0.012-0.428, p=0.064). Stratification by ethnicity indicated no elevation in prolactin level in Turkish patients with BD (SMD=0.127, 95% CI=-0.111-0.366, p=0.295). Stratification by disease activity revealed no elevation in prolactin level in both the active and inactive BD groups compared with the control group (SMD=0.373, 95% CI=-0.095-0.841, p=0.119; SMD=0.055, 95% CI=-0.243-0.354, p=0.717). Stratification by sex revealed no elevation in prolactin level in both the female and male BD groups (SMD=0.031, 95% CI=-0.398-0.460, p=0.888; SMD=0.279, 95% CI=-1.411-1.969, p=0.746). The prolactin levels were not significantly elevated in patients with BD, regardless of the adjustments for age/sex, sample size, or data type evaluated. This meta-analysis of current evidence suggests that circulating prolactin levels may not be higher in patients with BD than in controls. PMID: 29412808 [PubMed - in process]
Conclusion BD may be diagnosed earlier if it is considered and investigated during the assessment of ON, particularly in high-risk regions. Prognosis of ON related to BD seems to be favorable. Immunosuppressants should be given along with corticosteroids. MS-like presentations should also be kept in mind in patients with BD and ON.
We report a case of successful treatment of a ruptured popliteal artery aneurysm with a stent-graft insertion.
Authors: Deng Y, Zhu W, Zhou X Abstract Behcet's disease (BD) is a chronic refractory multi-system autoimmune disorder that occurs in a genetically susceptible host. Multiple genetic factors have been identified that may contribute to the pathogenesis of BD. The major genes with polymorphisms associated with BD include HLA-B and -A, CIITA, ERAP1, MICA, IL10, IL12A, IL12RB2, IL23R, MEFV, IRF8, TNFAIP3, REL, TLR4, NOD1,2, CCR1,CCR3, GIMAP1,2,4, KLRC4, STAT4, NCOA5, FOXP3, PSORS1C1, FUT2, UBAC2, SUMO4, ADO-EGR2, CEBPB-PTPN1, and JPKL-CNTN5. These genes encode proteins involved mainly in immune regulation and inflammat...
We appreciate the interest of Ertan Yetkin and Selcuk Ozturk in our published article "Characteristic Echocardiographic Manifestations of Behcet's Disease" and thank them for their comments. Consistent with most of the previous studies (Han et al. 2009), the most common cardiac involvement in patients with Behçet's disease (BD) in our study was severe aortic regurgitation. Some distinctive echocardiographic features of severe aortic insufficiency caused by BD are redundant motion of elongated aortic cusps or prolapsed aortic cusps with aneurysmal changes, vegetation-like mobile lesions and ...
We have read the article “Characteristic Echocardiographic Manifestations of Behcet's Disease” by Pu et al. with great enthusiasm. In their retrospective study, they reported echocardiographic findings in patients with Behçet's disease (BD). Of the 63 patients enrolled in the study, aortic valve regurgitation (65.1%) was the most common pathology, followed by aortic dilation (20.6%) and mitral valve regurgitation (4.8%). On the basis of this study, we believe that several issues need to be discussed.
ConclusionSerum endocan may serve as a potential marker of disease activity in BD. Patients with genital ulcers, papulopastular lesions and arthritis showed higher serum endocan levels.
ConclusionIFX infusion should be considered for the control of acute PU, whereas repeated long-term IFX infusions were effective in reducing the number of episodes in refractory PU with fast regression and complete remission of complications.
We describe their management and the balancing act surrounding anticoagulation therapy in Behcet-related pulmonary vasculitis.
ConclusionsThis is the first report on characteristic metabolic profiles and potential metabolite biomarkers in serum for reliable diagnosis of BD using GC/TOF-MS.
This study mainly assessed whether 30 AG-positive RAS/BD (AG+RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects.MethodsThe blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG+RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects.ResultsWe found that 43.3%, 33.3%, 13.3%, 6.7%, and 20.0% of 30 AG+RAS/BD patients and 18.2%, 36.4%, 0%, 6.1%, and 9.1...