Circulating prolactin levels and Behcet's disease: A meta-analysis.
This study aimed to summarize the current evidence on the relationship between circulating prolactin levels and Behcet's disease (BD). We performed a meta-analysis comparing the serum/plasma prolactin levels in patients with BD with those of controls and performed a subgroup analysis based on ethnicity, disease activity, and sex. Ten articles with a total of 320 patients with BD and 259 controls were included. The prolactin levels were not significantly higher in the BD group than in the control group (SMD=0.208, 95% CI=-0.012-0.428, p=0.064). Stratification by ethnicity indicated no elevation in prolactin level in Turkish patients with BD (SMD=0.127, 95% CI=-0.111-0.366, p=0.295). Stratification by disease activity revealed no elevation in prolactin level in both the active and inactive BD groups compared with the control group (SMD=0.373, 95% CI=-0.095-0.841, p=0.119; SMD=0.055, 95% CI=-0.243-0.354, p=0.717). Stratification by sex revealed no elevation in prolactin level in both the female and male BD groups (SMD=0.031, 95% CI=-0.398-0.460, p=0.888; SMD=0.279, 95% CI=-1.411-1.969, p=0.746). The prolactin levels were not significantly elevated in patients with BD, regardless of the adjustments for age/sex, sample size, or data type evaluated. This meta-analysis of current evidence suggests that circulating prolactin levels may not be higher in patients with BD than in controls. PMID: 29412808 [PubMed - in process]
The hallmark of vasculitis is autoimmune inflammation of blood vessels and surrounding tissues, resulting in an array of constitutional symptoms and organ damage. The lung is commonly targeted in the more familiar ANCA-associated small vessel vasculitidies, but large and medium vessel vasculitides, including Takayasu arteritis, giant cell arteritis, polyarteritis nodosa, Behcet's disease, and necrotizing sarcoid granulomatosis, may also feature prominent pulmonary involvement. Pulmonary manifestations of these conditions include pulmonary arterial aneurysms, pulmonary hypertension, diffuse alveolar hemorrhage, pulmonary no...
International Journal of Rheumatic Diseases, EarlyView.
AbstractBackground/ ObjectivesMusculoskeletal manifestations are frequent in Adamantiades ‐Behcet's disease (ABD) but only represent non‐specific clinical findings. They have not been included in the two commonly used sets of classification criteria. The occurrence of musculoskeletal manifestations at ABD onset may even delay or obscure the diagnosis, therefore detailed knowledge of the different musculoskeletal manifestations is essential. Our objective was to describe musculoskeletal signs and their clinical course in Greek ABD patients.MethodsWe conducted a retrospective cohort study, which included all patients wit...
Abstract PMID: 30381603 [PubMed - in process]
Abstract The current understandings on cellular and molecular biology suggest that Th17 axis plays a pivotal role in Behcet's disease (BD) pathogenesis. Recently the role of serum amyloid-A (SAA) as a potential marker of disease activity in BD patients has been explored, and it has been reported that the occurrence of specific clinical features are significantly associated with high serum levels of this inflammatory mediator. The aim of this study was to investigate the cytokine-like activity of SAA in inducing Th17 differentiation from CD4 + T naive cells in BD. Purified peripheral monocytes from BD...
Abstract Behcet's disease is a rare condition that causes pathologic abnormalities in multiple systems, with vascular complications occurring between 7-29% of disease individuals, termed vasculo-Behcet's disease (vasculo-BD). Arterial complications portend the highest mortality in vasculo-BD. Here, we present a case of a young female with active vasculo-BD who failed endovascular repair with development of stent graft-induced pseudoaneurysms at the proximal and distal extents of the stent graft, necessitating open descending thoracic aortic repair. PMID: 30365964 [PubMed - as supplied by publisher]
CONCLUSION: The expression of miR-155 increased in BD and associated with upregulation of TNF-α and downregulation of CTLA-4 genes. PMID: 30366049 [PubMed - as supplied by publisher]
CONCLUSIONS: The findings suggest that mechanical root replacement combined with a low post-operative C-reactive protein level maintained through adjunctive immunomodulation therapy may lead to optimal surgical outcomes in Behcet's disease associated with severe aortic regurgitation. PMID: 30315793 [PubMed - as supplied by publisher]
CONCLUSION: Our results showed that the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population. We could not find any susceptibility role of this genetic locus for posterior uveitis in Behcet's disease. PMID: 30289285 [PubMed - as supplied by publisher]
To report the switch rate of conventional immunosuppressive (CIS) therapies to the biological agents (BA) in patients with refractory Behcet ’s uveitis (BU).