Translating Schizophrenia Population Genetics Findings to Neurobiological Mechanisms: The Case of KALRN-9

In the “post–genome-wide association study era,” we are increasingly being faced with the question: so what’s next? How do we derive biological meaning from single nucleotide variants (SNVs)? In this issue of Biological Psychiatry, Russell et al. (1) explore the neurobiological impact of a rare SN V (rs143835330, kalirin [KALRN] gene) associated with schizophrenia, on neuron morphology, protein function, and transcript stability. Their approach represents one informative way of inferring how genetic risk mechanisms impinge upon the brain.

Source: Biological Psychiatry - February 9, 2018 Category: Psychiatry Authors: Timothy R. Powell Tags: Early Career Investigator Commentary Source Type: research