The Ups and Downs of Thalamocortical Connectivity in Schizophrenia

In this issue of Biological Psychiatry, Giraldo-Chica et  al. (1) replicate and expand on findings in one of the most rapidly evolving stories about functional connectivity abnormalities in psychiatry. Using probabilistic tractography of diffusion-weighted images, they hypothesized that mediodorsal (MD) thalamus connections to the prefrontal cortex (PFC) would be reduced in patients with schizophrenia, and that this would relate to impairments in cognitive control. Their study therefore takes an important next step in understanding this crucial circuit.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research