Genetic variations and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus.

Genetic variations and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus. Curr Vasc Pharmacol. 2018 Feb 05;: Authors: Ramus SM, Petrovic D Abstract Atherosclerosis and its cardiovascular complications are the main cause of death in diabetic patients. Patients with diabetes mellitus have a greater than 10-fold risk of cardiovascular disease in their lifetime. The carotid intima-media thickness (cIMT), a surrogate marker for the presence and progression of atherosclerosis, predicts future cardiovascular events in asymptomatic subjects with type 2 diabetes mellitus (T2DM). This review focuses on genetic variants that contribute to the pathobiology of subclinical atherosclerosis in the setting of T2DM. Specifically, we devoted our attention to well-studied genes selected for their relevance for atherosclerosis. These include: the renin-angiotensin-aldosterone system (RAAS), apolipoprotein E (ApoE), methylenetetrahydrofolate reductase (MTHFR) and pro-inflammatory genes. The ever-growing availability of advanced genotyping technologies has made genome-wide association studies (GWAS) possible. Although several bioinformatics tools have been developed to manage and interpret the huge amounts of data produced, there has been limited success in the many attempts to uncover the biological meaning of the novel susceptibility loci for atherosclerosis. PMID: 29412115 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Source: Application of Clinical Genetics - Category: Genetics & Stem Cells Tags: The Application of Clinical Genetics Source Type: research
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Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Case Repot Source Type: research
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