Autoinducer2 affects trimethoprim ‐sulfamethoxazole susceptibility in avian pathogenic Escherichia coli dependent on the folate synthesis‐associate pathway

This study might provide further information in the search for potential drug targets for prophylaxis of avian colibacillosis and for auxiliary antibiotics in the treatment of avian colibacillosis.

In avian pathogenic Escherichia coli, exogenous AI‐2 increases the bacterial susceptibility to trimethoprim‐sulfamethoxazole (SXT) in a folate synthesis‐dependent pathway but not in the LsrR‐dependent manner.

Source: MicrobiologyOpen - February 9, 2018 Category: Microbiology Authors: Lumin Yu, Wenchang Li, Ming Zhang, Yunmei Cui, Xiaolin Chen, Jingtian Ni, Li Yu, Fei Shang, Ting Xue Tags: ORIGINAL RESEARCH Source Type: research