Lipid-lowering treatment in peripheral artery disease.
Lipid-lowering treatment in peripheral artery disease. Curr Opin Pharmacol. 2018 Jan 31;39:19-26 Authors: Katsiki N, Giannoukas AD, Athyros VG, Mikhailidis DP Abstract Peripheral artery disease (PAD) is characterized by increased cardiovascular (CV) risk, limb morbidity and all-cause mortality. According to the current guidelines (2016) of the American Heart Association/American College of Cardiology on the management of PAD patients, statin therapy is recommended for PAD patients in order to treat dyslipidemia and reduce CV risk. The present narrative review discusses the use of statins and other lipid-lowering drugs such as ezetimibe, fibrates, niacin, anacetrapib and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in PAD patients in terms of both CV and limb outcomes. The clinical implications of hypolipidemic drug therapy in special patient populations including those with metabolic syndrome, non-alcoholic fatty liver disease, chronic kidney disease and type 2 diabetes mellitus, which may frequently co-exist with PAD, are also considered. PMID: 29413998 [PubMed - as supplied by publisher]
Publication date: Available online 18 February 2019Source: Life SciencesAuthor(s): Xuyang Wang, Jinyu Pan, Hui Liu, Mingjun Zhang, Dian Liu, Lu Lu, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang AnAbstractAimsAbsent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its potential molecular mechanism.Main methodsSprague-Dawley rats were randomly divided into 4 groups: Control,...
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight the need for strengthening basic infrastructure for kidney care services for early detec...
A study by Illinois University found overindulging in alcohol as a teen alters the expression of a protein that controls fear and anxiety in the grey matter of the brain.
Condition: NAFLD Interventions: Behavioral: Diet change (red rice); Behavioral: Yoga Sponsors: University of Nottingham; Population Health and Research Institute, Trivandrum, Kerala, india; Holistic Health and Research Institute, Trivandrum, Kerala, India Recruiting
Condition: Transition Intervention: Other: Transition classes Sponsor: Milton S. Hershey Medical Center Recruiting
Condition: Peripheral Arterial Disease Interventions: Drug: Carnosine; Drug: Placebo Sponsors: Monash University; Monash Health Not yet recruiting
Conditions: Colorectal Neoplasms; Microbiota; Prognosis; Metabolic Syndrome; Sarcopenia Intervention: Other: no intervention Sponsors: University Hospital, Clermont-Ferrand; M2iSH laboratory; Benoit Chassaing Recruiting
Conditions: Weight Loss; PreDiabetes Interventions: Device: CGM; Other: Dietitian Sponsors: Stanford University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting
ConclusionsGDM/GH predict diabetes and hypertension in couples as a unit underscoring the concept of shared couple risk. These findings may help foster couple collaboration for cardiovascular risk reduction in the household
This study investigates whether resveratrol (RSV) plays a regulatory role by SphK1/S1P2 pathway in MCs proliferation and inflammation under high glucose condition. Herein, we found that RSV inhibited MCs proliferation and attenuated high glucose (HG)-induced FN, TGF-β1, ICAM-1, iNOS, SphK1 and S1P2 expression and inhibited SphK1 activity andS1P production, which was also in accordance with MCs transfected with wild-type SphK1WT plasmid. Furthermore, RSV remarkably reduced AP-1 and NF-κB activation. Overall, these results indicated that RSV could be a potential and valuable resource of natural compounds for DN tr...
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