A test for gene –environment interaction in the presence of measurement error in the environmental variable

Abstract The identification of gene–environment interactions in relation to risk of human diseases has been challenging. One difficulty has been that measurement error in the exposure can lead to massive reductions in the power of the test, as well as in bias toward the null in the interaction effect estimates. Leveraging previous work on linear discriminant analysis, we develop a new test of interaction between genetic variants and a continuous exposure that mitigates these detrimental impacts of exposure measurement error in ExG testing by reversing the role of exposure and the diseases status in the fitted model, thus transforming the analysis to standard linear regression. Through simulation studies, we show that the proposed approach is valid in the presence of classical exposure measurement error as well as when there is correlation between the exposure and the genetic variant. Simulations also demonstrated that the reverse test has greater power compared to logistic regression. Finally, we confirmed that our approach eliminates bias from exposure measurement error in estimation. Computing times are reduced by as much as fivefold in this new approach. For illustrative purposes, we applied the new approach to an ExGWAS study of interactions with alcohol and body mass index among 1,145 cases with invasive breast cancer and 1,142 controls from the Cancer Genetic Markers of Susceptibility study.
Source: Genetic Epidemiology - Category: Epidemiology Authors: Tags: RESEARCH ARTICLE Source Type: research

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SUMMARY Cancer is characterized by the disordered growth of cells that have high capacity of invasion to the tissues and organs. One of the types of tumour that has national incidence and high mortality is breast cancer. Studies show that in addition to hereditary factors, lifestyle and environmental factors, there are factors related to emotional distress (mourning), which interfere with the development of breast cancer. Thus, it is necessary to investigate if the experience of mourning can trigger the appearance of the tumour. For this, an integrative review was performed to verify the existence of the relationship betwe...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Majid S. Jabir, Ali A. Taha, Usama I. Sahib, Zainab J. Taqi, Ahmed M. Al-Shammari, Alya S. SalmanAbstractLinalool is a monoterpene alcohol which occurs naturally in several aromatic plants. The aims of this study are to load Linalool on gold nanoparticles, conjugate the complex with CALNN peptide, and investigate them for in-vitro anticancer activities against breast cancer (MCF-7) cell line. Linalool was obtained with 98% purity while gold nanoparticles and CALNN peptide were chemically synthesized. The formation of LIN-GNPs ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Alcohol is the cause of 1 in 13 of the 55,100 cases of breast cancer diagnosed each year in the UK, according to Public Health England.
Source: NHS Networks - Category: UK Health Source Type: news
To compare health behaviors (smoking, alcohol use, fruit and vegetable intake, and exercise frequency) and breast self-exam (BSE) between girls with breast cancer family history (BCFH+) and without (BCFH −) and assess associates of behaviors across all girls.
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Original article Source Type: research
Vivian J. Bea, Joan E. Cunningham, Anthony J. Alberg, Dana Burshell, Colleen E. Bauza, Kendrea D. Knight, Tonya R. Hazelton, Heidi Varner, Rita Kramer, Susan Bolick, Deborah Hurley, Catishia Mosley, Marvella E. Ford
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Breast cancer is the most prevalent cancer in the U.S., affecting almost 85 of every 100,000 Americans, according to recent data from the World Health Organization’s International Agency for Research on Cancer (IARC). Around the globe, 627,000 people are projected to die from breast cancer this year alone. The silver lining is that with early detection and proper care, breast cancer is among the most treatable forms of the disease. In the U.S., breast cancer deaths dropped by 40% between 1989 and 2015, thanks to better screening and access to care — but a large body of research suggests that widespread adoption...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized breast cancer news Source Type: news
This study aims to investigate the relationship between ERCC5 polymorphism and the breast cancer risk in the lower northeastern region women of Thailand. One hundred fifty five samples from breast cancer patients and 122 samples from healthy control group were analysed. Genomic DNA was extracted from white blood cell of all samples. The real-time polymerase chain reaction (qPCR) was used to demonstrate genetic polymorphism of ERCC5. The results showed that the ERCC5 rs751402 polymorphism variant AG was associated with an increased risk of breast cancer. The frequency of ERCC5 rs751402 in patients with breast cancer was hig...
Source: International Journal of Molecular Epidemiology and Genetics - Category: Genetics & Stem Cells Tags: Int J Mol Epidemiol Genet Source Type: research
oek Epidemiological studies have been used to show associations between modifiable lifestyle habits and the incidence of breast cancer. Among such factors, a history of alcohol use has been reported in multiple studies and meta-analyses over the past decades. However, associative epidemiological studies that were interpreted as evidence that even moderate alcohol consumption increases breast cancer incidence have been controversial. In this review, we consider the literature on the relationship between moderate or heavy alcohol use, both in possible biological mechanisms and in variations in susceptibility due to genet...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Nearly 10 million people around the world will die of cancer this year, according to new estimates from the World Health Organization’s International Agency for Research on Cancer (IARC). The IARC’s report, which was published Wednesday in CA: A Cancer Journal for Clinicians, was based on cancer incidence data from 185 countries around the world. Researchers estimated that there will be 18.1 million new diagnoses of cancer and 9.6 million cancer deaths in 2018. Those numbers — a marked increase from just six years ago, when cancer diagnoses were estimated at 14.1 million, and deaths at 8.2 million —...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Innovation Health Source Type: news
Abstract Cancer is increasing worldwide. Patterns of cancer are also changing. The evidence is summarised in the 2018 World Cancer Research Fund/American Institute for Cancer Research report Diet, Nutrition, Physical Activity and Cancer: a Global Perspective. The plasticity of cancer patterns implicates environmental factors as determinants of cancer, and nutrition influences key cellular and molecular processes that characterise cancer. Epidemiology identifies associations between aspects of diet, nutrition, and physical activity with one or more cancers; there is evidence for plausible mechanisms that imply that...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
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