Log in to search using one of your social media accounts:


A test for gene –environment interaction in the presence of measurement error in the environmental variable

Abstract The identification of gene–environment interactions in relation to risk of human diseases has been challenging. One difficulty has been that measurement error in the exposure can lead to massive reductions in the power of the test, as well as in bias toward the null in the interaction effect estimates. Leveraging previous work on linear discriminant analysis, we develop a new test of interaction between genetic variants and a continuous exposure that mitigates these detrimental impacts of exposure measurement error in ExG testing by reversing the role of exposure and the diseases status in the fitted model, thus transforming the analysis to standard linear regression. Through simulation studies, we show that the proposed approach is valid in the presence of classical exposure measurement error as well as when there is correlation between the exposure and the genetic variant. Simulations also demonstrated that the reverse test has greater power compared to logistic regression. Finally, we confirmed that our approach eliminates bias from exposure measurement error in estimation. Computing times are reduced by as much as fivefold in this new approach. For illustrative purposes, we applied the new approach to an ExGWAS study of interactions with alcohol and body mass index among 1,145 cases with invasive breast cancer and 1,142 controls from the Cancer Genetic Markers of Susceptibility study.
Source: Genetic Epidemiology - Category: Epidemiology Authors: Tags: RESEARCH ARTICLE Source Type: research

Related Links:

Authors: Horakova D, Bouchalova K, Cwiertka K, Stepanek L, Vlckova J, Kollarova H Abstract Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
Imagine you have a friend named Justin. He is a schoolteacher. Honest, hardworking, doesn’t smoke, rarely drinks alcohol, sleeps well, doesn’t take drugs, shows up at work every day. He has also chosen to be vegetarian. Another friend of yours, an auto mechanic named Tommy, eats fast food, loves fried chicken, drinks too much beer on the weekends, likes to drive fast cars, and sometimes gets into legal tangles. He smokes cigarettes, though has limited it to only half-a-pack per day. Late weekends, some weekday nights, sleep cut short to just two or three hours. Tommy is not a vegetarian, but likes his burgers r...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle Source Type: blogs
ConclusionsOur results indicate that higher vegetable intake, tea drinking, and fish oil supplementation may help post-therapy cognitive recovery for cancer patients.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusion: Adherence to high-quality diets and a prudent/healthy dietary pattern seem to be beneficial for breast cancer prognosis. No clear evidence for a benefit from special diets, soy products, or other supplements was found.Breast Care 2018;13:86-91
Source: Breast Care - Category: Cancer & Oncology Source Type: research
Background/Aim: The family of matrix metalloproteinases (MMPs) are responsible for the homeostasis of extracellular matrix components and their genetic polymorphisms may be associated with cancer susceptibility. The serum levels of MMP-1 have been reported to be lower in breast cancer patients than healthy subjects. In the current study, we aimed at investigating the contribution of a polymorphism in the promoter region of MMP-1 to breast cancer in Taiwan. Materials and Methods: The MMP-1 rs1799705 polymorphic genotypes were genotyped among 1,232 breast cancer patients and 1,232 healthy controls by the typical polymerase c...
Source: In Vivo - Category: Research Authors: Tags: Experimental Studies Source Type: research
Breast cancer (BC) incidence in Australian women aged 45 to 64 years ( ‘middle-aged’) has tripled in the past 50 years, along with increasing alcohol consumption and obesity in middle-age women. Alcohol and obe...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
Authors: Vieira R, Tobar JSS, Dardes R, Claudio L, Thuler S Abstract Background: Alcohol consumption is a well-established risk factor for breast cancer, but the evidence is mostly from developed countries. Brazil is going through a rapid demographic expansion, and studies of this relationship are also needed in such unexplored settings. Methods: We assessed the relationship between alcohol consumption and breast cancer risk among 1,506 Brazilian women (406 cases and 1,100 controls). Regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). All statistical tests were two-tailed. R...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
err L Abstract Regular consumption of alcohol increases the risk of developing (one or more of) several malignant conditions: the frequency of tumours in the aerodigestive tract, in the liver, in the colorectal region and in the breast is increased. The principal carcinogen component of alcoholic drinks is ethanol itself; the effect is unmistakably proportional to the daily/weekly dosage. Under the influence of alcohol-dehydrogenase, ethanol will metabolise to acetaldehyde, which is a known carcinogen. Among other things chronic alcohol consumption promotes the production of endogen hormones, affects the insulin-l...
Source: Magyar Onkologia - Category: Cancer & Oncology Authors: Tags: Magy Onkol Source Type: research
Authors: Qu J, Zhao X, Wang J, Liu C, Sun Y, Cai H, Liu J Abstract Previous studies have indicated that phospholipase A2 (PLA2) may be associated with tumorigenesis in human tissues. The present study aimed to investigate the association between plasma PLA2 activity and the breast cancer (BC) status of patients. Increased plasma PLA2 activity was detected in patients with breast cancer when compared with healthy controls. Plasma samples were obtained from patients with BC (n=169), patients with benign disease (BD; n=80) and healthy controls (n=81). PLA2 activity was assessed using a quantitative fluorescent assay w...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
ConclusionsMultiple SNPs inALDH1A1 were associated with increased risk of mortality after BC. Future BC studies examining the relationship betweenALDH1A1 and mortality should consider the modifying effects of alcohol consumption and NA ancestry.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
More News: Alcoholism | Breast Cancer | Cancer | Cancer & Oncology | Environmental Health | Epidemiology | Genetics | Study