A test for gene –environment interaction in the presence of measurement error in the environmental variable
Abstract The identification of gene–environment interactions in relation to risk of human diseases has been challenging. One difficulty has been that measurement error in the exposure can lead to massive reductions in the power of the test, as well as in bias toward the null in the interaction effect estimates. Leveraging previous work on linear discriminant analysis, we develop a new test of interaction between genetic variants and a continuous exposure that mitigates these detrimental impacts of exposure measurement error in ExG testing by reversing the role of exposure and the diseases status in the fitted model, thus transforming the analysis to standard linear regression. Through simulation studies, we show that the proposed approach is valid in the presence of classical exposure measurement error as well as when there is correlation between the exposure and the genetic variant. Simulations also demonstrated that the reverse test has greater power compared to logistic regression. Finally, we confirmed that our approach eliminates bias from exposure measurement error in estimation. Computing times are reduced by as much as fivefold in this new approach. For illustrative purposes, we applied the new approach to an ExGWAS study of interactions with alcohol and body mass index among 1,145 cases with invasive breast cancer and 1,142 controls from the Cancer Genetic Markers of Susceptibility study.
Breast cancer organisation Mamma Help in the Czech Republic has invented an alcohol-free, vitamin and nutrient packed beer which they hope will appeal to women undergoing chemotherapy.
We presented the first study utilizing both conventional and new analytics including ensemble method and predictive modeling based on smallest errors to predict BC risks. Predictive modeling of Generalized Regression Elastic Net Leave-One-Out demonstrated alcohol use (p = 0.0126) and age (p
(CNN) — People who eat dinner before 9 p.m. — or at least two hours before going to sleep — have a 20% lower risk of breast and prostate cancer than those who eat after 10 p.m. or go to bed shortly after supper, researchers found. “The mechanisms are not clear,” said Dr. Manolis Kogevinas, a research professor at the Barcelona Institute for Global Health in Spain and lead author of a new study on the topic. “What we know from experimental studies is that we are conditioned to function in different parts of the day. We — not only humans but all living organisms — have develope...
ConclusionThe suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing.Graphical abstract
Conclusion: Associations of alcohol consumption with breast cancer-free survival are similar in women with and without adjuvant hormone therapy. Future studies are warranted to elucidate potential mechanisms underlying the observed inverse associations. PMID: 29963111 [PubMed]
This study included 2,100 cancer-free postmenopausal women within the Nurses ’ Health Study and Nurses’ Health Study II cohorts. Percent breast density (PD), absolute dense (DA), and non-dense areas (NDA) were measured from digitized film mammograms using a computer-assisted thresholding technique; all measures were square root transformed. Alcohol consumption was assess ed with a food frequency questionnaire (0,
Conclusion The suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing. Graphical abstract
Buried in a new N.I.H. report are disturbing examples of coordination between scientists and the alcohol industry on a study that could have changed America ’ s drinking habits.
In another setback for the NIAAA's and alcohol industry's study of the " health benefits " of encouraging people to drink, Anheuser-Busch has pulled its funding from the clinical trial because recent controversy over how the research funding was solicited has undermined the study's credibility.According to anarticle by Roni Caryn Rabin in theNew York Times:" Brewing giant Anheuser-Busch InBev, one of five alcohol companies underwriting a $100 million federal trial on the health benefits of a daily drink, is pulling its funding from the project, saying controversy about the sponsorship threatens to undermine ...
The World Cancer Research Fund (WCRF) has bad news for lovers of bacon and booze: Eliminating processed meats and alcohol from your diet may help reduce your risk of developing cancer. The third report from the WCRF’s Continuous Update Project, an ongoing effort to inform consumers about lifestyle habits that may be related to cancer, provides numerous recommendations for people looking to minimize their risk of getting cancer. But two, in particular, are likely to cause a stir for many Americans. First, the WCRF recommends significantly or totally cutting back on processed meats including bacon, salami, hot dogs and...