Autism, schizophrenia, bipolar disorder share molecular traits, study finds

Most medical disorders have well-defined physical characteristics seen in tissues, organs and bodily fluids. Psychiatric disorders, in contrast, are not defined by such pathology, but rather by behavior.A UCLA-led study,publishedin Science, has found that autism, schizophrenia and bipolar disorder share some physical characteristics — and important differences — at the molecular level, specifically, patterns of gene expression in the brain. Gene expression is the process by which instructions in DNA are converted into a product, such as a protein.“These findings provide a molecular, pathological signature of these disorders, which is a large step forward,” said senior author Daniel Geschwind, a distinguished professor of neurology, psychiatry and human genetics and director of the UCLA Center for Autism Research and Treatment. “The maj or challenge now is to understand how these changes arose.”Researchers know that certain variations in genetic material put people at risk for psychiatric disorders, but DNA alone doesn ’t tell the whole story. Every cell in the body contains the same DNA; RNA molecules, on the other hand, play a role in gene expression in different parts of the body, by “reading” the instructions contained within DNA.Geschwind and the study ’s lead author, Michael Gandal, reasoned that taking a close look at the RNA in human brain tissue would provide a molecular profile of these psychiatric disorders...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Authors: Dome P, Faludi G Abstract Main indications of antidepressants (ADs) as major depressive disorder (MDD) and different kinds of anxiety disorders are quite prevalent during pregnancy and the postpartum period. Due to the possible hazards of in utero and breast milk exposition of ADs, both psychiatrists and mothers frequently have concerns about the use of ADs during the periods of pregnancy and breastfeeding. However, we should also bear in mind that affective disorders left untreated during these periods are also associated with health risks for the mother and the baby as well. Accordingly, the treatment of...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
Authors: Rihmer Z, Dome P, Gonda X, Rihmer A, Belteczki Z Abstract The authors tested the clinical applicability of a self-developed, 6-item, clinician-rated questionnaire evaluating suicide risk in suicidal and non-suicidal psychiatric inpatients and healthy controls. Results have shown that the questionnaires able to detect marked suicide risk in psychiatric inpatients with a high sensitivity and specificity which indicates its usefulness and good applicability in clinical practice. PMID: 29790848 [PubMed - in process]
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
CONCLUSIONS: The short version of the Hungarian TEMPS-A is a promising instrument both in clinical fields and for academic research. The newly developed short version proved to be a valid and reliable measure of affective temperaments. PMID: 29790847 [PubMed - in process]
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
CONCLUSIONS: Individuals with ATPD have a very high risk of developing persistent psychotic disorders and may benefit from early detection and preventive treatments to improve their outcomes. PMID: 29787962 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
CONCLUSIONS: To the best of our knowledge, the present review is the first to specifically explore the relationship between social cognition and social functioning in patients with BD. This exploration is of interest, as it enhances current understanding of this disorder and, by so doing, should improve patient outcomes. PMID: 29787961 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
CONCLUSIONS: History of ELM as well as the common sequelae, BPD and MDD, pose risks for child abuse. Our findings suggest improvement of emotion regulation as a potential target for intervention programs. These programs should also aim at non-substantiated cases because even an elevated abuse potential affected child mental health.Declaration of interestNone. PMID: 29792587 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Depression, alcoholism, and other psychiatricillnesses share disease-related “signatures”involving a disruption in how brain cells communicate with each other.Thestudy, entitled “Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap,” by Michael J. Gandal et. al., appears inScience,  February 9, 2018.A Washington Postarticle on the study says:“The scientists found similar levels of particular molecules in the brains of people with autism, schizophrenia and bipolar disorder; other commonalities between bipolar and major depression; and oth...
Source: Addiction Inbox - Category: Addiction Authors: Source Type: blogs
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders—autism, schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polyge...
Source: ScienceNOW - Category: Science Authors: Tags: Genetics reports Source Type: news
People have said this to me many times over the years. Here’s another Wheat Belly Basics conversation for newcomers or a refresher for the seasoned Wheat Belly follower. One of the reason that wheat and related grains are such effective causes of weight gain is that they contain a protein, gliadin, that, upon digestion, yields opioid peptides that bind to the opiate receptors of the human brain. These opioid peptides are responsible for generating addictive relationships with food, as well as behavioral and emotional effects. Stop eating grains and an opiate withdrawal syndrome ensues: nausea, headache, fatigue, depr...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle addiction appetite stimulant binge eating bulimia Detox eating disorders gluten gluten-free grain-free grains health opiates opioids Weight Loss wellness withdrawal Source Type: blogs
AbstractWe review progress made concerning the participation of candidate genes in the determination of attention deficit disorder with hyperactivity (ADHD) as well as recent evidence on its genetic determination based on molecular methodology. In addition to linkage analyses, we discuss recent results obtained through genome-wide association studies (GWAS). We also discuss the genetic comorbidity estimated between ADHD and major psychiatric disorders such as schizophrenia (E), major depressive disorder (MDD), bipolar disorder (BD), and autism spectrum disorders (ASD). Furthermore, we examine both the geographical distribu...
Source: Current Genetic Medicine Reports - Category: Genetics & Stem Cells Source Type: research
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