The Drug-Drug Interaction Profile of Presatovir.

This study enrolled 64 healthy subjects to evaluate the effect of cyclosporine, a P-gp, BCRP, and OATP1B1/1B3 inhibitor; rifampin, a strong CYP3A4 and P-gp inducer; efavirenz, a moderate CYP3A4 inducer; and cobicistat, a potent CYP3A inhibitor, on presatovir pharmacokinetics. Presatovir plasma exposures (maximum observed plasma concentration [Cmax ] and area under the plasma concentration-time curve from time 0 extrapolated to infinity [AUCinf ]) were not affected by coadministration of cyclosporine, suggesting presatovir is not a sensitive substrate of P-gp, BCRP, or OATP1B1/1B3. As expected, based on the role of CYP3A in presatovir metabolism, presatovir exposure was increased by cobicistat (122% in AUCinf ), and decreased by rifampin (40.3% in Cmax and 82.5% in AUCinf ) and efavirenz (55.7% in AUCinf ). These data support coadministration of presatovir with inhibitors of P-gp, BCRP, OATP1B1/1B3, or CYP3A, but not with moderate or strong CYP3A4 inducers. Presatovir was well-tolerated with the most common drug-related adverse events of dizziness (n = 12) and somnolence (n = 4) reported during efavirenz treatment. PMID: 29412463 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Pharmacol Source Type: research

Related Links:

Abstract Anterior gradient protein 2 homolog (AGR) is a potential tumor biomarker and plays an important role in tissue development and regeneration. The intracellular detection of AGR is rarely reported. By conjugating the AGR aptamer with a cytosine base sequence as Ag cluster template, a highly fluorescent probe (MA@AgNCs) was synthesized for targeting intracellular AGR. The MA@AgNCs display a maximum fluorescence peak at 565 nm, and possess an excellent quantum yield (QY = 87.43%), small size, great biocompatibility, low toxicity, and good stability. Moreover, the as synthesized MA@AgNCs show high specific...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Juanying Xie, Ran Liu, Joseph Luttrell, Chaoyang Zhang
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Women want to receive results from their screening mammograms quickly, according...Read more on AuntMinnie.comRelated Reading: Women unaware of importance of baseline mammography Mammo recalls don't keep women from other tests Women want to know their breast cancer risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 19 February 2019Source: Journal of Bone OncologyAuthor(s): C. Wilson, C. Martin, M.C. WinterAbstractBackgroundAdjuvant bisphosphonates (BPs) are recommended as part of routine early breast cancer treatment for many postmenopausal (PM) women within the past year. There is a paucity of ‘real world’ data on compliance and patient satisfaction with oral BPs in this population. The aim of our study was to investigate patient reported compliance and toxicity of these drugs in a retrospective cohort study.Patients and methods413 patient were identified as receiving adjuvant oral BPs ...
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Incremental cost - effectiveness ratio varies across clinical risk groups, sensitive to patient age
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gynecology, Oncology, Pathology, Journal, Source Type: news
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gynecology, Oncology, Research, Preventive Medicine, News, Source Type: news
Condition:   Breast Cancer Intervention:   Drug: Imaging Drug FluorThanatrace (FTT) Sponsor:   University of Pennsylvania Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, to achieve the combined photothermal-chemotherapy of breast cancer, a pH-sensitive oxidized hyaluronic acid-decorated dihydroxyphenyl/hydrazide bifunctionalized hydroxyethyl chitosan (DHHC)-gold nanorod (GNR) conjugate was developed. DHHC was synthesized by successive dihydroxyphenylation and hydrazidation of hydroxyethyl chitosan through carbodiimide reaction and click chemistry, respectively. The conjugate was obtained by chemically bonding DHHC onto GNR via Au-catechol bonds. Doxorubicin (DOX) was loaded onto the conjugate via an acid-labile hydrazone linkage with a drug loading content of 5.1%. DOX-loade...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 February 2019Source: European Journal of Surgical OncologyAuthor(s): Kang Wang, Yang Shi, Zhu-Yue Li, Ye-Lei Xiao, Jie Li, Xiang Zhang, Hong-Yuan LiAbstractIntroductionRole of surgery in the management of de novo stage IV breast cancer (BC) remains controversial. We aimed to determine the survival benefit of primary surgery on the basis of metastatic pattern.Materials and methodsA retrospective cohort study based on the SEER database was conducted to identify patients with de novo stage IV BC diagnosed between 2010 and 2015. Patients were divided into surgery and non-surgery group, and...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
TUESDAY, Feb. 19, 2019 -- Women who have specific mutations in genes known as BRCA are at increased risk for breast and ovarian cancers. Now, an influential expert panel reaffirms that certain women should be screened for the genes. The draft...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
More News: Breast Cancer | Cancer | Cancer & Oncology | Children | Organic | Respiratory Medicine | Restasis | Study