Advanced PET imaging in oncology: status and developments with current and future relevance to lung cancer care
Purpose of review This review highlights the status and developments of PET imaging in oncology, with particular emphasis on lung cancer. We discuss the significance of PET for diagnosis, staging, decision-making, monitoring of treatment response, and drug development. The PET key advantage, the noninvasive assessment of functional and molecular tumor characteristics including tumor heterogeneity, as well as PET trends relevant to cancer care are exemplified. Recent findings Advances of PET and radiotracer technology are encouraging for multiple fields of oncological research and clinical application, including in-depth assessment of PET images by texture analysis (radiomics). Whole body PET imaging and novel PET tracers allow assessing characteristics of most types of cancer. However, only few PET tracers in addition to 18F-fluorodeoxyglucose have sufficiently been validated, approved, and are reimbursed for a limited number of indications. Therefore, validation and standardization of PET parameters including tracer dosage, image acquisition, post processing, and reading are required to expand PET imaging as clinically applicable approach. Summary Considering the potential of PET imaging for precision medicine and drug development in lung and other types of cancer, increasing efforts are warranted to standardize PET technology and to provide evidence for PET imaging as a guiding biomarker in nearly all areas of cancer treatment.
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Dalia M. Kabary, Maged W. Helmy, Kadria A. Elkhodairy, Jia-You Fang, Ahmed O. Elzoghby The self-tumor targeting polymers, lactoferrin (LF) and hyaluronic acid (HA) were utilized to develop layer-by-layer (LbL) lipid nanoparticles (NPs) for dual delivery of berberine (BER) and rapamycin (RAP) to lung cancer. To control its release from the NPs, BER was hydrophobically ion paired with SLS prior to incorporation into NPs. Spherical HA/LF-LbL-RAP-BER/SLS-NPs 250.5 nm in diameter, with a surface charge of −18.5 mV ...
CONCLUSIONS: Initiatives emphasising the timeliness of diagnosis and treatment are reflected in the ways some patients experience their care. However, these accounts were open to further contextualisation about what speed of healthcare processes meant for evaluating the quality of their care. Healthcare professionals could therefore be an important patient resource in providing reassurance and support about the timeliness of diagnosis or treatment. PMID: 29784144 [PubMed - in process]
CONCLUSION: The study highlights the importance of recognizing symptoms as a combination of different experiences that may each cause different levels of distress. Initial evidence is provided that the emotional work involved for patients to self-manage each separate element of breathlessness should be considered in its treatment. PMID: 29784142 [PubMed - in process]
CONCLUSIONS: SEE-ACBT is an effective and economical short-term pulmonary rehabilitation method. Pulmonary rehabilitation should focus on increasing motivational behaviours. Further studies should be implemented to explore the long-term effects of SEE-ACBT. PMID: 29784132 [PubMed - in process]
CONCLUSIONS: EBUS-TBNA revealed a specific cause for suspected non-malignant lymphadenopathy in one-third of cases and was associated with excellent specificity. Predominant specific causes were granuloma, besides from tumor. In 3 patients pathogen could be isolated by TBNA. PMID: 29788514 [PubMed - as supplied by publisher]
The Florida Supreme Court has refused to give emergency relief to Tampa strip clude owner Joseph Redner in his attempt to lift an appeals court order blocking him from growing his own medical marijuana to treat his late stage lung cancer. The state’s highest court sided with the Florida Department of Health to leave a state appeals court order in place which blocked Redner from growing his own medicinal cannabis until the appeals process was complete. Redner has failed to demonstrate that the…
(MedPage Today) -- Wide variation in groups at highest risk of turning down treatment
Condition: Lung Cancer Intervention: Procedure: Hybrid APC Sponsor: Jiayuan Sun Not yet recruiting
The incidence of lung cancer in young women has now surpassed that of their male counterparts, and the unique smoking behaviors of men and women don't explain why.Medscape Medical News
LONDON (Reuters) - AstraZeneca's immunotherapy drug Imfinzi has hit a second important goal by improving overall survival in lung cancer patients, boosting prospects for a medicine that has already got off to a promising commercial launch.