Decitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cells

Decitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cellsDecitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cells, Published online: 09 February 2018; doi:10.1038/s41388-018-0125-3Decitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cells
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research

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LUNG cancer symptoms may only appear when the condition becomes more advanced, which may make it harder to treat. The number of people surviving one year with the condition rose to 38 per cent in 2015, according to the National Lung Cancer Audit. You should never ignore unexplained weight loss, which could be a sign of the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
LUNG cancer symptoms may only appear when the condition becomes more advanced, which may make it harder to treat. The number of people surviving one year with the condition rose to 38 per cent in 2015, according to the National Lung Cancer Audit. You should never ignore unexplained weight loss, which could be a sign of the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Future cachexia trials would likely benefit from studying a single tumour type with earlier stage disease, with probably different dosage depending on the cancer type and its inflammatory profile. PMID: 29779814 [PubMed - in process]
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Clin Nutr ESPEN Source Type: research
(MedPage Today) -- This week's topics include occluding the atrial appendage and stroke, a pragmatic smoking trial, a relative rise in lung cancer among women, and the benefits of egg consumption
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Zizheng Song, Yan Shi, Quanli Han, Guanghai Dai Special targeted therapy like endothelial growth factor receptor (EGFR) targeted therapy is available for the treatment of advanced non-small cell lung cancer (NSCLC). Biodegradable core-shell lipid-polymer hybrid nanoparticles (LPNs) can combine the beneficial properties of lipid and polymeric NPs for controlled drug delivery. In the present study, epidermal growth factor (EGF) conjugated LPNs were fabricated to co-deliver docetaxel (DTX) and resveratrol (RSV). In vitro and in v...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Sulforaphane-N-acetyl-cysteine (SFN-NAC) is a potential drug to inhibit human non-small cell lung cancer (NSCLC), but the underlying mechanisms are elusive. Here, we uncovered that SFN-NAC induced apoptosis via flow cytometer assay and transmission electron microscopy. Further, SFN-NAC increased LC3 II/LC3 I and the number of LC3 punctas, but Western blot showed that SFN-NAC inhibited cell autophagy in response to a co-treatment of Bafilomycin A1 and SFN-NAC. Furthermore, immunofluorescence staining and Western blot showed that SFN-NAC triggered microtubule disruption causing apoptosis via downregulating α-tubulin an...
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Dalia M. Kabary, Maged W. Helmy, Kadria A. Elkhodairy, Jia-You Fang, Ahmed O. Elzoghby The self-tumor targeting polymers, lactoferrin (LF) and hyaluronic acid (HA) were utilized to develop layer-by-layer (LbL) lipid nanoparticles (NPs) for dual delivery of berberine (BER) and rapamycin (RAP) to lung cancer. To control its release from the NPs, BER was hydrophobically ion paired with SLS prior to incorporation into NPs. Spherical HA/LF-LbL-RAP-BER/SLS-NPs 250.5 nm in diameter, with a surface charge of −18.5 mV ...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
In this study, the interaction between the microbiota of the lower respiratory tract and the type of immune response against Mycobacterium tuberculosis were studied. Bronchoalveolar lavage (BAL) samples of 10 tuberculosis (TB) patients and 5 cases suspected of lung cancer as control were obtained. Clinical symptoms were recorded for the TB patients. Serial dilutions of samples were prepared and cultured on a selective medium in order to count Streptococcus spp., Neisseria spp., Haemophilus spp. and Veillonella in the lung. To determine the type of immune response of Th1/Th2, Real Time-PCR method was used. The prevalence of...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
AbstractPurpose of reviewThe introduction of antiretroviral therapy (ART) has revolutionized HIV infection management, resulting in improved outcomes and survival for people living with HIV (PLWH). However, as PLWH are living longer and aging, non-AIDS-defining cancers (NADCs) represent a significant source of morbidity and mortality in the HIV-infected population. Here, we review the epidemiology of NADCs in PLWH.Recent findingsCancer mortality among PLWH is much higher than that among the general population. Up to 10% of deaths among PLWH have been attributed to NADCs. Furthermore, PLWH have an increased risk for specifi...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
Conclusion The PP for lung cancer in male population was 2.5 times higher than females. There was a 3.2% increase in the Irs over the study period. To facilitate early diagnosis for better management associated to pharmacotherapy or surgical care, our findings emphasized the advantage of further research and greater effort toward environmental, job related exposure, genetic and geographical factors in Isfahan Province/Iran.
Source: Journal of the Egyptian National Cancer Institute - Category: Cancer & Oncology Source Type: research
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