HealthWatch: Amino Acid Fuels Aggressive Form of Breast Cancer
BOSTON (CBS) – A new study says diet could affect the spread of a deadly type of breast cancer. Researchers at Cedars-Sinai found that an amino acid called asparagine, which is found in many types of food, may fuel tumor cells. When the scientists eliminated asparagine from the diets of mice with “triple-negative” breast cancer, the cancer was less likely to travel to distant sites in the body. Asparagine is found in dairy, beef, poultry, eggs, fish, nuts, whole grains, and asparagus, but most fruits and vegetables are low in asparagine. Does this mean that you should remove all these foods from your diet? Of course not, but researchers say this is more evidence that what we eat can change the course of disease. And perhaps for people with this type of resistant breast cancer, changing their diet could make a difference.
Authors: Fletcher SJ, Hapon MB, Callegari EA, Crosbie ML, Santiso N, Ursino A, Amato AR, Gutiérrez A, Sacca PA, Dreszman R, Pérez A, Carón RW, Calvo JC, Pistone-Creydt V Abstract Tumor progression depends on the tumor-stroma interaction. In the breast, adipose tissue is the predominant stromal type. We have previously demonstrated that conditioned media (CMs) from explants of human adipose tissue of tumor breasts (hATT) increase proliferation and migration of breast cancer epithelial cells when compared to human adipose tissue from normal breasts (hATN). In this work, we aim to identify specifi...
Authors: Knudsen ES, Zacksenhaus E PMID: 30123416 [PubMed]
Authors: Pitson SM, Powell JA PMID: 30123415 [PubMed]
Emre Karakus, Daniel Zahner, Gary Grosser, Regina Leidolf, Cemal Gundogdu, Alberto S ánchez-Guijo, Stefan A. Wudy, Joachim Geyer
Haixia Chen, Jianming Wu, Zhihong Zhang, Yong Tang, Xiaoxuan Li, Shuangqing Liu, Shousong Cao, Xianzhu Li
In this study, we examined whether CCL4 gene single nucleotide polymorphisms (SNPs) predict the risk and progression of breast cancer. Between 2014 and 2016, we recruited 314 patients diagnosed with breast cancer and a cohort of 209 healthy participants (controls) without a history of cancer. Genotyping of the CCL4 rs1634507, rs10491121 and rs1719153 SNPs revealed no significant between-group differences for these polymorphisms. However, amongst luminal A and luminal B subtypes, compared with patients with the AA genotype, those carrying the AG genotype at SNP rs10491121 were less likely to develop lymph node metastasis. I...
Those who perceived that they received hypnosis had significantly reduced fatigue and anxiety
A lump in the breast can be a sign of breast cancer, but other changes in the breast can also signify this condition. Other potential warning signs include texture changes, nipple discharge, and breast pain. Learn more about eight possible symptoms of breast cancer besides a lump, and when to see a doctor.
Conditions: Sentinel Lymph Node; Breast Cancer; Tattoo; Pigmentation; Axilla; Breast Intervention: Device: Tattooing of biopsied node Sponsor: Derby Hospitals NHS Foundation Trust Recruiting
Conditions: Aging; Breast Cancer; Chemotherapeutic Toxicity; Survival Intervention: Sponsor: Peking University People's Hospital Active, not recruiting