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FDA Again Advises Against Morcellators for Fibroids FDA Again Advises Against Morcellators for Fibroids

The risk for uterine sarcoma being found in fibroids is too high, notes Dr Markman.Medscape Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

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Authors: Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, George S, Han E, Higgins S, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL Abstract Endometrial carcinoma is a malignant epithelial tumor that forms in the inner lining, or endometrium, of the uterus. Endometrial carcinoma is the most common gynecologic malignancy. Approximately two-thirds of endometrial carcinoma cases are diagnos...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
In conclusion, BCOR ITD is an oncogenic alternative to YWHAE-NUTM2 fusion in high-grade uterine sarcomas with uniform nuclear features. We propose that neoplasms with the morphology described and BCOR ITD be regarded as a unique subtype of high-grade uterine sarcoma, possibly within the family of endometrial stromal neoplasia.
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Conclusions The use of clinical parameters and multiparametric MRI as predictive factors was beneficial for diagnosing uterine sarcoma preoperatively. These findings could be helpful for guiding treatment decisions.
Source: Academic Radiology - Category: Radiology Source Type: research
The risk for uterine sarcoma being found in fibroids is too high, notes Dr Markman.
Source: Medscape Oncology - Category: Cancer & Oncology Authors: Source Type: podcasts
Authors: Chen I, Firth B, Hopkins L, Bougie O, Xie RH, Singh S Abstract Background and Objectives: Uterine fibroids are a common indication for laparoscopy. Unsuspected sarcoma can pose a serious risk if morcellation is used in the procedure. We sought to determine the clinical factors associated with uterine sarcoma compared with uterine fibroids. Methods: We conducted a case-control study of 66 women who had hysterectomy for uterine sarcoma from April 1, 2007, to March 31, 2014. Sixty-six patients who had hysterectomy for fibroids were randomly selected as controls. Results: Women with sarcoma vs women wi...
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
This study aimed to investigate the intensity of FDG uptake/metabolic activity for the differential diagnosis of benign and malignant gynaecological tumours. MethodsThis study included seven patients with physiological phenomena, 34 with benign tumours, 13 with borderline malignant tumours and 119 with malignant tumours who underwent 18F‐FDG PET/CT. We assessed the maximum standardized uptake value (SUVmax) and determined its utility in the diagnosis of benign and malignant tumours using a receiver operating characteristic (ROC) curve analysis. ResultsAmong the 63 patients with ovarian tumours, the mean SUVmax of 22 pati...
Source: Australasian Radiology - Category: Radiology Authors: Tags: Medical Imaging —Original Article Source Type: research
Human Gene Therapy Feb 2018, Vol. 29, No. 2: 242-250.
Source: Human Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
Publication date: February 2018 Source:Gynecologic Oncology Reports, Volume 23 Author(s): Francesco Raspagliesi, Giorgio Bogani, Domenica Lorusso
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
This report highlights these entities' diagnostic features, namely having a neoplastic benign or mildly atypical epithelial component, and sar comatous (often low-grade) stromal component. Architecturally, they resemble phyllodes tumour. Stromal projections are lined by benign or mildly atypical Müllerian-type epithelia. Heterologous elements may be present, or there may be sex cord-like differentiation.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Short case Source Type: research
Pure mesenchymal tumours of the uterus broadly comprise two major categories, smooth muscle neoplasms and endometrial stromal neoplasms. Of these the most common tumours are smooth muscle tumours of the uterus, the majority of these are benign and are recognised as leiomyomata routinely. Leiomyosarcoma is the commonest malignant mesenchymal tumour of the uterus accounting for>50% of uterine sarcomas and comprising 1 –2% of uterine malignancies. Variants of both benign and malignant tumours are recognised and increasingly, through the evolution of more sophisticated immunohistochemistry and molecular techniques we ...
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Gynaecological pathology Source Type: research
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