Fibromyalgia Associated With Corneal Sensitivity, Ocular Pain Fibromyalgia Associated With Corneal Sensitivity, Ocular Pain
Patients with fibromyalgia have increased eye sensitivity and pain, researchers from Turkey report.Reuters Health Information
This study explored the mediating role of catastrophizing, acceptance, and coping in the relationship between pain and emotional distress/disability in a FM sample. Ninety-two FM patients and 51 healthy participants controls were evaluated on pain- and psychological-related variables. Catastrophizing, acceptance, behavioral coping, and emotional coping were significantly correlated with emotional distress and/or disability. Catastrophizing had a significant effect as a mediator on the relationship between pain and depression/anxiety. The current management of FM could improve by including cognitive techniques aimed at modi...
• We review temporal summation and conditioned pain modulation in fibromyalgia (FM).• Results revealed pain sensitization and defective endogenous pain modulation in FM• Sensitivity analysis uncovered multiple modifying covariates• Lack of blinding is a critical issue in most of the studies reviewed• The paradigms studied may serve future diagnosis, treatment and research on FM.
Mirogabalin is an α2δ ligand being developed to treat pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and fibromyalgia. Although mirogabalin is primarily excreted in urine as unchanged parent drug, a small fraction is also metabolized by hepatic uridine 5'-diphospho-glucuronosyltransfer ase isoforms. Hepatic impairment (HI) may also affect systemic exposure. Additionally, impaired hepatic function is common in subjects with diabetes. Therefore, a phase 1, open-label, single-dose study was conducted to compare the pharmacokinetics (PK) of mirogabalin after a single dose of 15 ...
Assessment of physical functioning is critical for evaluating treatment effectiveness. Patient-reported and performance-based measures of physical functioning are commonly used in clinical trials of chronic pain treatments, but there is growing interest in the application of accelerometer devices to objectively measure physical activity and track movement patterns over time. All three measurement approaches have different strengths and weaknesses, but the relationships between patient-reported, performance-based, and accelerometer-based measures of physical functioning are not well understood.
This study aimed to evaluate the Widespread Pain Index (WPI), previous ly used as a diagnostic tool for fibromyalgia in adults and adolescents, to determine its validity in assessing pain extent in youth. The WPI includes: 1) pain location score (19-items; pain presence/absence), and 2) symptom severity score (6-items; 0–3 Likert scale); higher scores indicate greate r pain extent and symptom severity.
The objective of this study was to identify inter-relationships between fibromyalgia pain, sleep disruption, and cognitive/emotional factors that may related to both sleep and pain.
Chronic pain in adolescents is a serious issue that can lead to decreased social interactions, school absences, and impaired academic performance. In addition to physiologic, psychologic, and social factors, parental anxiety is believed to contribute to the development and maintenance of chronic pain. Retrospectively, we examined the charts of 144 patients, ages 8 –18, with various chronic pain conditions and placed them into one of six diagnostic groups: complex regional pain syndrome, abdominal pain, back pain, hypermobility, headache, and fibromyalgia.
Fibromyalgia (FM) is a chronic pain condition characterized by heightened sensitivity to mechanical (as well as other modalities) stimuli. While on average FM patients display substantial hyperalgesia, inter-patient variability is large, and the degree of hyperalgesia is known to associate with the magnitude of patients' spontaneous daily pain. To date however, little research has investigated the potential moderating effects of patient characteristics on the association between experimental pain and daily clinical pain.
Fibromyalgia (FM) is a chronic musculoskeletal pain condition that affects 2 –4% of the population and is characterized by anatomically widespread pain symptoms accompanied by fatigue, disturbed sleep and mood. In patients with fibromyalgia (FM), catastrophizing is related to greater pain severity, amplified pain sensitivity as well as higher anxiety that can disturb sleep . Understanding catastrophizing's mechanisms of action, therefore, would potentially provide valuable scientific information as well as pragmatic, treatment-related benefits in relation to sleep.
Fibromyalgia (FM) is a chronic musculoskeletal pain condition that affects 2 –4% of the, is characterized by anatomically widespread pain symptoms, and accompanied by fatigue, sleep and negative cognition. In patients with fibromyalgia (FM), catastrophizing is related to greater pain severity, amplified pain sensitivity, and higher anxiety. In the present study we explored the impact of yoga-based exercise over time on pain, fatigue, catastrophizing in patients with fibromyalgia. Participants rated FM symptoms including pain, as well as underwent psychosocial and psychophysical testing at baseline and then attended a...