Enzymatic amidation for industrial applications.

Enzymatic amidation for industrial applications.
Curr Opin Chem Biol. 2018 Feb 03;43:127-133
Authors: Dorr BM, Fuerst DE
Abstract
Nature has developed a robust toolbox for the formation of amide bonds, enabling a variety of disconnections applicable to small molecule synthesis. In spite of this, the exploitation of biocatalytic techniques for industrial synthesis remains limited to a few very important cases. This review discusses previously demonstrated techniques for the biocatalytic synthesis of amide bonds, reviews examples of industrial scale-up of these techniques, and identifies a number of limitations to the scalability within the current state of the art.
PMID: 29414531 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - February 3, 2018 Category: Biochemistry Authors: Dorr BM, Fuerst DE Tags: Curr Opin Chem Biol Source Type: research